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Using Excess Stress Can Kill Therapy Resistant Breast CancerA study published in Science Signaling by Kakajan Komurov, PhD suggests that maxing out the inherently stressed nature of treatment-resistant breast cancer cells thwarts their adaptive ability to evolve genetic workarounds to treatment. Learn more.
Bio-marker identified in hard-to-treat asthma patientsWhy do some asthma patients respond well to corticosteroids while others do not? A new study reveals that VNN-1 gene expression is required for corticosteroids to be effective during an asthma attack. Gurjit Khurana Hershey, MD, PhD and her research team discovered the revealing bio-marker and are using their findings to develop new treatments for hard-to-treat asthma cases. Read more.
New research links ADHD and conduct disorder in young adolescents with increased alcohol and tobacco use. William Brinkman, MD, was lead author in the study published in the journal Drug and Alcohol Dependence. Read More.
A new type of cell transplantation developed to treat mice mimicking a rare lung disease could one day be used to treat this and other human lung diseases caused by dysfunctional immune cells. The study was published online Oct. 1 by Nature. Bruce Trapnell, MD is senior author. Read More.
Twin study provides cancer clues
By studying the genomes of twin 3-year-old sisters,
researchers have uncovered a molecular pathway involving the gene SETD2 that
could lead to better treatments for aggressive leukemia. The study was published online Feb. 9 in Nature
Genetics. Gang Huang, PhD, a researcher in the divisions
of Pathology and Experimental Hematology and Cancer Biology was a co-corresponding author. Read More.
Progress in gene therapy for Hurler syndromeIn a mouse study, researchers have successfully used blood
platelets and bone marrow cells to deliver potentially curative gene therapy to
treat Hurler syndrome. The
study appeared online Feb. 3 in Proceedings
of the National Academy of Sciences (PNAS). Dao Pan, PhD, a researcher in the Division of Experimental Hematology and Cancer Biology, was corresponding author.
HPV vaccine does not change sexual behavior
study published online Feb. 2 in Pediatrics finds no evidence that the human papillomavirus (HPV) vaccine leads to unsafe
sexual behaviors among teenage girls and young women. Jessica Kahn, MD, a physician in
the Division of Adolescent and Transition Medicine was senior author.
test can predict death risk from septic shock
A new test that measures five key biomarkers can quickly and
accurately predict the risk of death in children with septic shock, according
to a study published online Jan. 29 in PLOS ONE. The multi-institutional
study was led by Hector Wong, MD, Director, Division of Critical Care Medicine at Cincinnati Children’s and Christopher
Lindsell, PhD, UC College of Medicine. Read More.
Stem cell breakthrough
A basic signaling pathway known to play important roles in normal cell and cancer cell formation also plays an unexpected role as a molecular switch that controls the aging process of hematopoietic stem cells (HSCs), according to a study published online Oct. 20, 2013, in Nature. The study was led by Hartmut Geiger, PhD, Experimental Hematology and Cancer Biology. Read More.
Teen obesity risks Severely obese teens are four times more likely to have swollen legs with skin ulcers as adults and three times more likely to develop severe walking limitations and abnormal kidney function, according to a study published online Nov. 18, 2013, in Pediatrics by Thomas Inge, MD, PhD, and colleagues. Read More.
Antioxidant Treatment May Reduce NF1-Linked Behavioral Issues
Treatment with antioxidants may help reduce behavioral issues linked to neurofibromatosis 1 (NF1) and an associated condition, Costello syndrome. Findings were posted Sept. 12 in Cell Reports. The study was led by Nancy Ratner, PhD, Division of Experimental Hematology and Cancer Biology. Read More.
Controlling the protein RhoA could help fight a variety of blood and immune system disorders, according to a study published online Oct. 7 in the Journal of Experimental Medicine. Yi Zheng, PhD, director of Experimental Hematology and Cancer Biology, was principal investigator. Read More.
Prostate cancer advance
A study involving mouse models published Aug. 2, 2013, in the Journal of Biological Chemistry reports that depleting the FoxM1 protein in prostate epithelial cells inhibits tumor cell proliferation and metastasis. Tanya Kalin, MD, PhD, a physician-scientist in Pulmonary Biology was senior author. Read More.
Fighting resistant leukemia
Findings posted online April 26, 2013, in Leukemia report that an experimental combination treatment was effective against T-cell acute lymphoblastic leukemia (T-ALL) in mouse models and human cells in the lab. Fukun Guo, PhD, a researcher in Experimental Hematology and Cancer Biology, is first author. Read More.
Insulin and breastfeeding
RNA sequencing reveals in detail how insulin resistance can lead to insufficient breast milk production. The study, led by Laurie Nommsen-Rivers, PhD, at Cincinnati Children’s and scientists at the University of California Davis, was published in July 5, 2013, in PLOS ONE. The findings suggest a potential biomarker to predict which women may have difficulty breastfeeding. Read More.
Drug reduces seizures
Everolimus can dramatically reduce seizures in patients with tuberous sclerosis complex (TSC), according to a study posted online June 24, 2013, in Annals of Neurology. The study was led by Darcy Krueger, MD, PhD, at Cincinnati Children’s in collaboration with a team at Texas Children’s Hospital. Read More.
New target for treating MDS
Scientists at Cincinnati Children’s have successfully targeted a malfunctioning immune system enzyme to kill diseased cells from patients with myelodysplastic syndrome (MDS). The study, led by Daniel Starczynowski, PhD was published July 8, 2013, in Cancer Cell. Read More.
Traffic pollution and ADHD
In a study published May 21, 2013 in Environmental Health Perspectives, a team led by Nicholas Newman, DO, MS, director of the Pediatric Environmental Health and Lead Clinic at Cincinnati Children’s, reported that children exposed to high levels of traffic-related air pollution (TRAP) during their first year of life were more likely to have “at risk” scores for hyperactivity by age 7. Read More.
Medical device risks
The same modern medical devices that have helped extend and enhance life for so many children also can cause complications that have not been well-understood, according to a study led by Patrick Brady, MD, MSc, a physician in the Division of Hospital Medicine. Findings were posted online June 7, 2013, in the Journal of Hospital Medicine. Read More.
Anesthesia and the brain
Beyond the known effects that surgical anesthesia can have on the developing brains of young children, new findings posted June 5 the Annals of Neurology suggest the threat may also apply to adult brains. The study was led by Andreas Loepke, MD, PhD, a physician and researcher in the Department of Anesthesiology. Read More.
14 more JIA genes An international team of researchers led by Cincinnati Children’s has confirmed 14 more genes linked to juvenile idiopathic arthritis (JIA), bringing the total to 17. The study involved patient DNA samples from across the United States, Germany and United Kingdom, says Susan Thompson, PhD, a researcher in the Division of Rheumatology who was a leader in the project. Findings were published April 21, 2013, in Nature Genetics. Read More.
New biomarker for NEC Two distinct microbial imbalances in the digestive tract may serve as biomarkers to predict the onset of necrotizing enterocolitis (NEC), according to a study led by Ardythe Morrow, PhD. Findings were published April 16, 2013, in the journal Microbiome. Read More.
Alternative to bariatric surgery Manipulating bile acid levels may be enough to recreate the key effects of bariatric surgery without the need for an invasive procedure, according to a study led by Rohit Kohli, MBBS, MS, a member of the Division of Gastroenterology. Findings were published online April 16, 2013, in Endocrinology. Read More.
Bubble Boy Breakthrough For children with X-SCID, a new version of gene therapy shows renewed promise. A boy treated when he was 8 months old is doing well several months after receiving experimental therapy through a clinical trial at Cincinnati Children’s. Read More.
Targeting Cancer Stem Cells Scientists at UC and Cincinnati Children’s report that a new molecular pathway may offer a new way to kill leukemia cancer stem cells that survive traditional forms of treatment. Findings were published in June 2012 in the journal Blood. Our researchers also are using new lines of “humanized” mice to explore the potential of microRNA inhibitors and small-molecule inhibitors as anti-cancer weapons. Read More.
Closer to Conquering HLH The 10-center Hybrid Immunotherapy for HLH (HIT-HLH) trial, led by Michael Jordan, MD, is the first US-based clinical trial to focus on this condition. Researchers at Cincinnati Children’s also are studying a promising antibody, a possible gene replacement therapy and targeted drug therapies to improve HLH treatment. Read More.
Light and Eye Development Even in the womb, the eye needs light to develop normally. This and other unexpected findings could change our understanding of how the retina develops, according to a study published online Jan. 16, 2013, in Nature. The paper was co-authored by Richard Lang, PhD, a researcher in the Division of Pediatric Ophthalmology at Cincinnati Children’s and David Copenhagen, PhD, a scientist at UCSF. Read More.
Kidney Removal Unnecessary Thousands of people have had kidneys removed unnecessarily because doctors misdiagnose patients who actually have tuberous sclerosis complex (TSC), according to a study published online Jan. 11, 2013, in Lancet. Proper diagnosis could have led to a medication that would have made surgery or kidney removal unnecessary, according to John Bissler, MD, a nephrologist at Cincinnati Children’s and lead author of the study. Read More.
Teen Girls Face Online Risks Thirty percent of teen girls report having offline meetings with strangers and semi-strangers they meet on the Internet, according to a study published online in Pediatrics. The study, led by says Jennie Noll, PhD, a psychologist in Behavioral Medicine and Clinical Psychology at Cincinnati Children’s, shows the risk is further heightened for teen girls who have been victims of abuse or neglect. Read More.
Progress Against NF1 Tumors A preclinical study in mice successfully used targeted molecular therapy to block mostly untreatable nerve tumors caused by the genetic disorder Neurofibromatosis 1 (NF1). The study was led by Nancy Ratner, PhD, program leader for the Cancer Biology and Neural Tumors Program in the Cancer and Blood Disorders Institute. Findings were published online Dec. 10, 2012, in the Journal of Clinical Investigation. Read More.
Smoking and Osteoporosis Teenage girls who smoke accumulate less bone during a critical growth period and carry a higher risk of developing osteoporosis later in life, according to research published Dec. 4, 2012, in the Journal of Adolescent Health. The study was led by Lorah Dorn, PhD, director of research in the Division of Adolescent Medicine. Read More.
Gene Linked to Deafness A research team led by Cincinnati Children’s has discovered a genetic mutation responsible for deafness associated with Usher syndrome type 1. These findings offer a potential target for new therapies, says Zubair Ahmed, PhD, senior investigator. The study results were published online Sept. 30 in Nature Genetics. Read More.
Marijuana and Preeclampsia Marijuana consumption may increase risks of preeclampsia and other pregnancy complications, according to SK Dey,PhD, director, Division of Reproductive Sciences. Analysis of mouse models indicates that THC can affect placenta development. Findings appeared Sept. 14 in The Journal of Biological Chemistry. Read More.
ATV Safety Warning labels are not working. Tougher rider training and helmet laws are needed to reduce deaths among underaged All-Terrain Vehicle (ATV) riders, according to Rebeccah Brown, MD. She presented new findings about ATV crashes Oct. 22 at American Academy of Pediatrics annual meeting in New Orleans. Read More.
How Epilepsy Seizures Begin Molecular disruptions in granule cells – located in the dentate gyrus region of the brain – caused brain seizures in mice similar to those seen in human temporal lobe epilepsy, according to a study led by Steven Danzer, PhD, a neuroscientist in the Department of Anesthesia. The findings appeared Sept. 19 in Neuron. Read More.
Rhosin Shows Promise A small-molecule-inhibiting drug dubbed “Rhosin” stopped breast cancer cells from metastasizing and promoted nerve cell growth in early laboratory cell tests. Although years away from market, Rhosin eventually could treat a variety of cancers and could promote spinal cord regeneration, says lead investigator Yi Zheng, PhD, director of Experimental Hematology and Cancer Biology. Findings appeared June 21 in Chemistry & Biology. Read more.
Predicting Readmissions A geographic social risk index based on income, home values and the parents’ education levels can help hospitals predict which children with asthma are most likely to need readmission, according to research led by Andrew Beck, MD. Study results were posted online Oct. 18 in the American Journal of Public Health. Read More.
Vaccine for Preterm Birth The mechanisms involved in preventing a pregnant woman’s body from rejecting her baby as a foreign object eventually may lead to a new class of vaccines that could prevent preterm births and possibly other autoimmune diseases, according to Sing Sing Way, MD, PhD, a physician researcher in Infectious Diseases. Findings were published online Sept. 26 in the journal Nature.
Snoring and Behavior Persistent and loud snoring in young children can make preschool behavior problems worse, according to Dean Beebe, PhD, director of the neuropsychology program at Cincinnati Children’s. Behaviors affected by snoring include hyperactivity, depression and inattention. Findings were published online Aug. 13 in Pediatrics. Read More.
HPV Vaccine Reach Grows The HPV vaccine does more than protect the vaccinated. A study led by Jessica Kahn, MD, MPH, a physician in the division of Adolescent Medicine at Cincinnati Children’s, is the first to document that the vaccine also provides herd immunity. Findings were published online July 9 in Pediatrics. Read More.
Detecting At-Risk Athletes A 9-minute modified echocardiogram is more effective than EKG at detecting athletes at risk of sudden cardiac death, according to a study led by Michelle Grenier, MD, a physician at the Cincinnati Children’s Heart Institute Findings were presented in July at the annual meeting of the American Society of Echocardiography. Read More.
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