Mattia Quattrocelli, PhD

Assistant Professor, UC Department of Pediatrics

About

Biography

My lab investigates molecular mechanisms and translatable biomarkers that play a role in the dysfunction and rescue of striated muscles. Our lab aims to combine genetics, epigenetics and metabolism, to garner a deeper understanding of muscle physiology and pharmacology.

An essential focus of the lab centers on "precision dosing" for glucocorticoid steroids in heart and muscle regulation. Glucocorticoids, such as dexamethasone, prednisone and deflazacort, are widely used as immunosuppressants. They have a pervasive, yet overlooked, impact on metabolic homeostasis and striated muscle function.

We are investigating how repetitive versus pulsatile regimens of glucocorticoids remodel energy production and performance in several contexts of disease, including obesity, unhealthy aging and heart failure. Moreover, we are leveraging the newly discovered pharmacological mechanisms to expand the concept of precision dosing for these drugs to "chrono-pharmacology." In this line of investigation, we are learning what the circadian and molecular mechanisms are that govern steroid pharmacology and physiological response in striated muscles. Previously, we discovered that a change in intake frequency dramatically changes the effects of glucocorticoid steroids from pro-obesity to anti-obesity.
Most recently, I received the NIH National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) K01 Development Award (2019).

Additional recognitions and awards include:

Silver Medal Award at Jamboree International Genetically Engineered Machine (IGEM) International Competition, Massachusetts Institute of Technology (MIT), USA, (2008)
First European Molecular Biology Association (EMBO) prize for Poster Presentation at the Advanced Scientific Computing Research (ASCR) EMBO meeting, Paris, France, (2011)
International Society for Stem Cell Research (ISSCR) Travel Grant for 10th ISSCR International Congress, Yokohama, Japan, (2012)
Flanders (FWO) Fellowship (postdoctoral), (Belgium, (2013)
Duchenne Parent Project Award for Best Presentation at 11th Indian Institute of Management (IIM) International Congress, Italy, (2014)
French Muscular Dystrophy Association (AFM) Telethon Trampoline Grant (mentored research grant), Belgium, (2015)
Muscular Dystrophy Association American Association of Neuromuscular & Electrodiagnostic Medicine (AANEM) Development Grant #479350, (2017)
Postdoctoral Professional Development Travel Award from Northwestern University (2018)
National Institutes of Health (NIH) Outstanding Poster Award at New Directions in Biology and Disease of Skeletal Muscle Conference, New Orleans, LA, (2018)
Federation of American Societies for Experimental Biology (FASEB) Travel Award for Nutrient Sensing and Metabolic Signaling Conference, Snowmass, CO, (2018)
Poster Award, Dept. of Pharmacology Retreat, Northwestern University, Chicago, IL, (2019)

Interests

Muscle and heart physiology; pharmacology; epigenetics; metabolism

Research Areas

Molecular Cardiovascular Biology, Neuromuscular Development

Publications

Report and Abstracts of the 18th Meeting of the Interuniversity Institute of Myology: Virtual meeting, October 21-24, 2021. Grassi, F; Falcone, S. European Journal of Translational Myology. 2021; 31.

Anti-latent TGFβ binding protein 4 antibody improves muscle function and reduces muscle fibrosis in muscular dystrophy. Demonbreun, AR; Fallon, KS; Oosterbaan, CC; Vaught, LA; Reiser, NL; Bogdanovic, E; Velez, MP; Salamone, IM; Page, PG T; Hadhazy, M; et al. Science Translational Medicine. 2021; 13.

Abstract P397: MTCH2 As A Modifier Of Cardiomyopathy. Fischer, JA; Puckelwartz, M; Wolf, M; Quattrocelli, M; Pesce, L; Bauer, R; Kearns, S; McNally, EM. Circulation Research. 2021; 129.

Abstract 102: Time-of-intake Regulates Glucocorticoid Pharmacology Of Cardiac Bioenergetics. Quattrocelli, M; Wintzinger, M; Miz, K. Circulation Research. 2021; 129.

Guide Cells Support Muscle Regeneration and Affect Neuro-Muscular Junction Organization. Ronzoni, FL; Giarratana, N; Crippa, S; Quattrocelli, M; Cassano, M; Ceccarelli, G; Benedetti, L; Van Herck, J; De Angelis, MG C; Vitale, M; et al. International Journal of Molecular Sciences. 2021; 22.

Isolation of Mammalian Mesoangioblasts: A Subset of Pericytes with Myogenic Potential. Giacomazzi, G; Giovannelli, G; Rotini, A; Costamagna, D; Quattrocelli, M; Sampaolesi, M. Methods in Molecular Biology. 2021; 2235:155-167.

Mechanisms and Clinical Applications of Glucocorticoid Steroids in Muscular Dystrophy. Quattrocelli, M; Zelikovich, AS; Salamone, IM; Fischer, JA; McNally, EM. Journal of Neuromuscular Diseases. 2021; 8:39-52.

A gene-edited mouse model of limb-girdle muscular dystrophy 2C for testing exon skipping. Demonbreun, AR; Wyatt, EJ; Fallon, KS; Oosterbaan, CC; Page, PG; Hadhazy, M; Quattrocelli, M; Barefield, DY; McNally, EM. DMM Disease Models and Mechanisms. 2020; 13.

Healthy, mtDNA-mutation free mesoangioblasts from mtDNA patients qualify for autologous therapy. van Tienen, F; Zelissen, R; Timmer, E; van Gisbergen, M; Lindsey, P; Quattrocelli, M; Sampaolesi, M; Mulder-den Hartog, E; de Coo, I; Smeets, H. Stem Cell Research and Therapy. 2019; 10.

Pulsed glucocorticoids enhance dystrophic muscle performance through epigenetic-metabolic reprogramming. Quattrocelli, M; Zelikovich, AS; Jiang, Z; Peek, CB; Demonbreun, AR; Kuntz, NL; Barish, GD; Haldar, SM; Bass, J; McNally, EM. JCI insight. 2019; 4.