Overview
The Rothenberg laboratory is focused on elucidating the mechanisms of allergic responses especially in mucosal tissues such as the lung and the gastrointestinal tract. The goal of the research is to identify novel pharmaceutical targets for the treatment of patients with eosinophilic diseases including eosinophilic gastrointestinal disorders, hypereosinophilic syndromes, asthma and food allergies. The laboratory has identified and biologically characterized several critical pathways that regulate allergic responses. These discoveries include eosinophil effector mechanisms and the chemokine eotaxin/CCR-3 pathway. Current projects are:
- To elucidate the cellular and molecular processes involved in allergic responses in the gastrointestinal tract and lung using novel models of allergic responses in vivo and in-vitro.
- To test the importance of key molecule including chemokines and cytokines in vivo using transgenic and gene-targeted mice.
- To biochemically characterize the signal transduction mechanism responsible for eosinophil development and activation.
- To test the importance and blockade of these pathways in patients with inflammatory diseases such as eosinophil and hypereosinophilic syndromes.
- To identify genes and key check points that predispose to eosinophil disorders.
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