A photo of Margaret Collins.

Margaret H. Collins, MD


  • Staff Pathologist, Division of Pathology
  • Director, GI Pathology
  • Professor, UC Department of Pathology and Laboratory Medicine
  • UC Department of Pediatrics

About

Biography

I belong to a community of researchers at Cincinnati Children’s Hospital Medical Center, plus other institutions here and abroad, who are unwaveringly committed to finding cures for pediatric gastrointestinal (GI) diseases, including eosinophilic gastrointestinal disorders (EGID). This is especially important to me after meeting patients and their caregivers, witnessing the impact that EGID has on their lives and sharing their hope for a Food and Drug Administration (FDA)-approved therapy.

My research strives to improve diagnostic methods for children with GI diseases, such as EGID and inflammatory bowel disease. As a pediatric pathologist at Cincinnati Children’s, I help evaluate the efficacy of various therapies, including biologics, for pediatric patients who have EGID. I also participate in multi-institutional studies of pediatric inflammatory bowel disease.

I helped create the eosinophilic esophagitis histology scoring system (EoEHSS), which systematically evaluates esophageal biopsies obtained for eosinophilic esophagitis, the most common form of EGID. Some of the features evaluated correlate with symptoms and potentially provide new therapeutic endpoints.

Beginning in 2011, U.S. News & World Report named me one of the Top Doctors in Pathology. In 2020, I received the American Academy of Asthma, Allergy and Immunology (AAAAI) and American Partnership for Eosinophilic Disorders (APFED) award for the best EGID abstract at the AAAAI annual meeting.

Publications

Selected

Eosinophilic Gastrointestinal Disorders Pathology. Collins, MH; Capocelli, K; Yang, G. Frontiers in Medicine. 2018; 4.

Selected

Creating a multi-center rare disease consortium - the Consortium of Eosinophilic Gastrointestinal Disease Researchers (CEGIR). Cheng, K; Gupta, SK; Kantor, S; Kuhl, JT; Aceves, SS; Bonis, PA; Capocelli, KE; Carpenter, C; Chehade, M; Collins, MH; et al. 2017; 2:141-155.

Selected

Factors associated with early outcomes following standardised therapy in children with ulcerative colitis (PROTECT): a multicentre inception cohort study. Hyams, JS; Davis, S; Mack, DR; Boyle, B; Griffiths, AM; LeLeiko, NS; Sauer, CG; Keljo, DJ; Markowitz, J; Baker, SS; et al. The Lancet Gastroenterology and Hepatology. 2017; 2:855-868.

Selected

Efficacy of a 4-Food Elimination Diet for Children With Eosinophilic Esophagitis. Kagalwalla, AF; Wechsler, JB; Amsden, K; Schwartz, S; Makhija, M; Olive, A; Davis, CM; Manuel-Rubio, M; Marcus, S; Shaykin, R; et al. Clinical Gastroenterology and Hepatology. 2017; 15:1698-1707.e7.

Selected

Histologic Correlates of Clinical and Endoscopic Severity in Children Newly Diagnosed With Ulcerative Colitis. Boyle, B; Collins, MH; Wang, Z; Mack, D; Griffiths, A; Sauer, C; Markowitz, J; LeLeiko, N; Keljo, D; Rosh, J; et al. American Journal of Surgical Pathology. 2017; 41:1491-1498.

Selected

Mucosal Expression of Type 2 and Type 17 Immune Response Genes Distinguishes Ulcerative Colitis From Colon-Only Crohn's Disease in Treatment-Naive Pediatric Patients. Rosen, MJ; Karns, R; Vallance, JE; Bezold, R; Waddell, A; Collins, MH; Haberman, Y; Minar, P; Baldassano, RN; Hyams, JS; et al. Gastroenterology. 2017; 152:1345-1357.e7.

Selected

Newly developed and validated eosinophilic esophagitis histology scoring system and evidence that it outperforms peak eosinophil count for disease diagnosis and monitoring. Collins, MH; Martin, LJ; Alexander, ES; Boyd, JT; Sheridan, R; He, H; Pentiuk, S; Putnam, PE; Abonia, JP; Mukkada, VA; et al. Diseases of the Esophagus. 2017; 30:1-8.

233. ENDOSCOPIC REFERENCE SCORE AND HISTOLOGICAL SCORING SYSTEM ARE COMPLEMENTARY ASSESSMENTS FOR CHARACTERIZING FIBROSTENOTIC OR INFLAMMATORY PHENOTYPES IN EOSINOPHILIC ESOPHAGITIS PATIENTS. Collins, MH; Rothenberg, ME; Bredenoord, AJ; Wechsler, J; Chehade, M; Philpott, H; Chen, Z; Radwan, A; Pela, T; Khodzhayev, A; et al. Gullet. 2022; 35.

Management of eosinophilic esophagitis associated food impaction in Europe and the United States. Schreiner, P; Safroneeva, E; Schoepfer, A; Greuter, T; Biedermann, L; Schlag, C; Labenz, J; Auth, MK H; Bredenoord, AJ; Chang, JW; et al. Diseases of the Esophagus. 2022; 35.

Reply. Dellon, ES; Collins, MH; Furuta, GT; Aceves, SS. Gastroenterology. 2022.

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