Though our primary area of focus in epigenomics is T cell memory, we are interested in epigenetic regulation in other systems as well. For this reason, we collaborate with many researchers studying epigenetic and transcriptional regulation in many other systems.
The major goal of this project, led by Satoshi H. Namekawa, PhD and funded by the NIGMS (2R01GM098605), is to elucidate the roles of DNA damage response pathways in the chromosome-wide silencing of the sex chromosome during male meiosis in the mouse.
The major goal of this project, funded by the NIEHS (1R21ES027117), is to elucidate the epigenetic roles of histone lysine crotonylation during late spermatogenesis and in paternal epigenetic inheritance to the next generation in response to endocrine disrupters.
The major goal of this project, led by Marc E. Rothenberg, MD, PhD and funded by the NIAID (Project 2, 2U19AI070235), is to evaluate whether the decreased expression of this inhibitor (SPINK7) promotes allergic responses by unleashing a protease-dependent, pro-inflammatory response that is accompanied by loss of epithelial barrier function and production of pro-allergic mediators.
The major goals of this project are to investigate the following: 1) whether matrix fibroblast are important for alveolar epithelial cell differentiation during realveolarization; 2) whether there is transcriptional regulation of matrix fibroblast function during regeneration; and 3) what epigenetic modifications regulate matrix fibroblast gene expression. This project is led by Anne Karina T. Perl, MS, PhD and funded by the NHLBI (R01HL131661).
The goal of this project, which is led by Ting Wen, MD, PhD and funded by Cincinnati Children’s (Trustee Award), is to elucidate the involvement of FFAR3 in Th2 cells pathology of eosinophilic esophagitis (EoE) and unravel epigenetic regulation of FFAR3 expression.
The major goal of this project, led by Simon P. Hogan, PhD and funded by the Crohn’s & Colitis Foundation of America, is understanding the role of novel LIRB3 isoform in Crohn disease. My collaborative role is identifying the novel LIRB3 TSS using epigenomics data.
The Namekawa and Barski Labs report in BCM Biology ("Poised chromatin and bivalent domains facilitate the mitosis-to-meiosis transition in the male germline") that in addition to developmental genes that were previously known to possess bivalent domains, a large group of somatic genes is silenced by bivalent domains during the mitosis-to-meiosis transition in spermatogenesis.
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