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The goal of the Hogan laboratory is to understand the immune-intestinal epithelial interactions during homeostasis and how alterations in these pathways predispose to the development and maintenance of chronic inflammatory diseases such as food allergy and anaphylaxis, infection-induced diarrheal diseases, cystic fibrosis (CF) and inflammatory bowel disease (IBD).
We take a multidisciplinary approach that integrates in vitro and in vivo models and cell and epithelial biology, transport physiology and mucosal immunology to 1) define fundamentals of epithelial barrier function; 2) understand the role of the epithelial barrier in regulating other mucosal processes, e.g. immune responses; 3) identify immune pathways that modulate epithelial barrier function and how these pathways alter susceptibility and severity to disease; and 4) develop novel approaches to correct barrier dysfunction and restore health.
Epithelial layers form a single- or multi-cell layer that protects the body from the external environment. This fundamental barrier property is essential for survival of multicellular organisms and permits controlled interactions between the external environment and different tissues. The epithelium acts as a selective barrier. It drives ion and water secretion and the selective absorption of critical components for survival, including nutrients (carbohydrates, ions, proteins and fatty acids), while being selectively impermeable to environmental toxins, infectious and non-infectious pathogens, commensal bacteria and environmental particulates.
The epithelium regulates transcellular ion and water movement via ion channels and transporters and maintains the selective barrier and regulation of paracellular transport through a group of proteins known as tight junction (TJ) proteins. Through homo- and hetero-dimeric interactions these transmembrane proteins (claudins and occludin) form a complex network of sealing strands that constitute a selective permeable barrier. Recent investigations have demonstrated that epithelial ion secretion and barrier function is regulated by various environmental factors (commensal bacteria, infectious pathogens), immune cells (mast cells, eosinophils, macrophages and CD4+ T cells) and molecules (prostaglandins, leukotrienes, cytokines, histamine and proteases). Dysregulation of these pathways can lead to altered epithelial ion secretion and barrier function, which predisposes to inflammatory diseases such as food allergy and anaphylaxis, IBD and cystic fibrosis (CF).
Simon P. Hogan, PhDAssociate Professor of Pediatrics
Division of Allergy and ImmunologyCincinnati Children's Hospital Medical CenterUniversity of Cincinnati College of Medicine3333 Burnet Avenue, MLC 7028Cincinnati, OH 45229
Phone: 513-636-6620Fax: 513-636-3310Email: email@example.com
The photomicrograph above depicts the expression of the tight junction proteins claudin-3 and E-cadherin in the small intestine of mice and is part of the lab's ongoing research.
Hogan is the director of admissions for the Immunobiology Graduate Training Program and mentors graduate students and postdoctoral fellows, as well as clinical fellows from the Allergy / Immunology Fellowship Program, in basic and translational research.
Interested in doing research in the Hogan Lab? Contact us about current research opportunities.
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