• Intestinal Immuno-Epithelial Interactions in Health and Disease

    The goal of the Hogan laboratory is to understand the immune-intestinal epithelial interactions during homeostasis and how alterations in these pathways predispose to the development and maintenance of chronic inflammatory diseases such as food allergy and anaphylaxis, infection-induced diarrheal diseases, cystic fibrosis (CF) and inflammatory bowel disease (IBD).

    We take a multidisciplinary approach that integrates in vitro and in vivo models and cell and epithelial biology, transport physiology and mucosal immunology to 1) define fundamentals of epithelial barrier function; 2) understand the role of the epithelial barrier in regulating other mucosal processes, e.g. immune responses; 3) identify immune pathways that modulate epithelial barrier function and how these pathways alter susceptibility and severity to disease; and 4) develop novel approaches to correct barrier dysfunction and restore health.


  • Research Opportunities

    Research Opportunities

    Research opportunities with the Hogan Lab include graduate, postdoctoral and clinical fellowships. Our research is furthered by the excellence, dedication and collaborative outlook of our lab members.

    Meet the Lab
  • Publications

    This photomicrograph depicts the expression of the tight junction proteins claudin-3 and E-cadherin in the small intestine of mice and is part of the lab's ongoing research.

    This photomicrograph depicts the expression of the tight junction proteins claudin-3 and E-cadherin in the small intestine of mice and is part of the lab's ongoing research.

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