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Simon P. Hogan, PhD, was awarded funding from the Cincinnati Children's Research Innovation/Pilot Funding Program in 2016. This program will support the Hogan Lab in investigating the involvement of antibiotics in antigen sensitization in food allergy.
Simon P. Hogan, PhD, director of research for the Division of Allergy and Immunology, was recognized for his dedicated efforts with the Mentoring Achievement Award in the Fourth Annual Faculty Awards by Cincinnati Children's.
The Hogan Lab's recent publication in Immunity, Inflammation and Disease demonstrates that loss of the phosphatidylinositol 3-kinase (PI3K) activating signal triggered by IL-4Rα does not alter susceptibility to immunoglobulin E (IgE)-mediated, food-induced experimental anaphylaxis. However, mice without functional IL-4Rα-mediated PI3K signaling have accelerated disease progression, revealing an unanticipated role for IL-4Rα-mediated PI3K signaling in putting the brakes on IgE-mediated anaphylactic reactions.
Simon P. Hogan, PhD, was elected as a fellow in the Fellows of The Graduate School, an organization that recognizes distinguished researchers and scholars from throughout the University of Cincinnati. In addition to their outstanding individual accomplishments, fellows are generally among the most experienced and accomplished graduate-student mentors at the university.
The goal of the Hogan Laboratory is to understand the immune-intestinal epithelial interactions during homeostasis and how alterations in these pathways predispose to the development and maintenance of chronic inflammatory diseases such as food allergy and anaphylaxis, infection-induced diarrheal diseases, cystic fibrosis (CF) and inflammatory bowel disease (IBD).
We take a multidisciplinary approach that integrates in vitro and in vivo models and cell and epithelial biology, transport physiology and mucosal immunology to 1) define fundamentals of epithelial barrier function; 2) understand the role of the epithelial barrier in regulating other mucosal processes, e.g. immune responses; 3) identify immune pathways that modulate epithelial barrier function and how these pathways alter susceptibility and severity to disease; and 4) develop novel approaches to correct barrier dysfunction and restore health.
Research opportunities with the Hogan Lab include graduate, postdoctoral and clinical fellowships. Our research is furthered by the excellence, dedication and collaborative outlook of our lab members.
This photomicrograph depicts the expression of the tight junction proteins claudin-3 and E-cadherin in the small intestine of mice and is part of the lab's ongoing research.
Simon P. Hogan, PhD
Associate ProfessorUC Department of Pediatrics
Member, Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center
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Phone: 513-636-6620Fax: 513-636-3310Email: firstname.lastname@example.org
Read more about the epithelial barrier.
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