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Intestinal Immuno-Epithelial Interactions in Health and Disease
The goal of the Hogan laboratory is to understand the immune-intestinal epithelial interactions during homeostasis and how alterations in these pathways predispose to the development and maintenance of chronic inflammatory diseases such as food allergy and inflammatory bowel disease (IBD). In parallel with these mouse studies, we define the roles of leukocytes (monocyte / macrophages, mast cells and eosinophils) in intestinal inflammatory diseases by conducting studies of human monocyte / macrophages or by evaluating specimens derived from patients with food allergy and IBD.
Simon P. Hogan, PhDAssociate Professor of Pediatrics
Division of Allergy and ImmunologyCincinnati Children's Hospital Medical CenterUniversity of Cincinnati College of Medicine3333 Burnet Avenue, MLC 7028Cincinnati, OH 45229
Phone: 513-636-6620Fax: 513-636-3310Email: firstname.lastname@example.org
The photomicrograph above depicts the expression of the tight junction proteins claudin-3 and E-cadherin in the small intestine of mice and is part of the lab's ongoing research.
Hogan is the director of admissions for the Immunobiology Graduate Training Program and mentors graduate students and postdoctoral fellows, as well as clinical fellows from the Allergy / Immunology Fellowship Program, in basic and translational research.
Interested in doing research in the Hogan Lab? Contact us about current research opportunities.
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