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The Rothenberg laboratory is focused on elucidating the mechanisms of allergic responses, especially in mucosal tissues such as the gastrointestinal tract and lung. The goal of our research is to identify mechanisms of allergic inflammation with the aim of developing and testing novel pharmaceutical targets for the treatment and cure of patients with a variety of allergic diseases, especially eosinophilic gastrointestinal disorders (EGID) [e.g. eosinophilic esophagitis (EE or EoE)], hypereosinophilic syndrome (HES), asthma and food allergies.
We have identified and biologically characterized several critical pathways that regulate allergic responses. Our research integrates multidisciplinary basic studies, with particular emphasis on modern genetic approaches, translational research employing novel in vivo and ex vivo systems developed by our laboratory, and clinical studies designed to test proof-of-concept theories and novel therapeutics directly in humans.
Dr. Rothenberg leads within and outside of Cincinnati Children’s. He has greatly furthered the field of allergy and immunology, as evidenced by his extensive publications (over 250) and receipt of an NIH MERIT Award in recognition and support of his research. Rothenberg is a key founder of the Registry for Eosinophilic Gastrointestinal Disorders (REGID), is the Program Director of Cincinnati Children’s CHRCDA, and is the Director of Cincinnati Children’s Division of Allergy and Immunology and the Cincinnati Center for Eosinophilic Disorders (CCED).
There are several educational opportunities with the Rothenberg laboratory, including graduate, postdoctoral and clinical fellowships as well as summer research experiences. The Rothenberg laboratory has a high-energy, dynamic and interactive environment and is interested in recruiting self-motivated individuals with the drive to succeed and the desire to be competitive at the international level.
Eosinophils have been considered end-stage cells involved in host protection against parasites. However, numerous lines of evidence have now changed this perspective by showing that eosinophils are pleiotropic multifunctional leukocytes involved in initiation and propagation of diverse inflammatory responses, as well as modulators of innate and adaptive immunity.
We are examining new views on the role of eosinophils in homeostatic function, including developmental biology and innate and adaptive immunity (as well as interaction with mast cells and T cells). We are studying the molecular steps involved in eosinophil development and trafficking, with special attention to the important role of eosinophil selective cytokines such as IL-5 and the eotaxin subfamily of chemokines.
We are investigating the role of eosinophils in disease processes including infections, asthma and gastrointestinal disorders. We are studying the consequences of genetically engineering eosinophil-deficient mice. Genetic approaches to understanding eosinophil-associated human diseases are a focus area. Finally, we are pursuing strategies for targeted therapeutic intervention in eosinophil-mediated diseases.
Rothenberg is the author of more than 250 papers in basic science and clinical literature.
The Registry for Eosinophilic Gastrointestinal Disorders (REGID) is a collaboration of medical centers, professionals, families and individuals whose mission is to improve the knowledge, research and outcomes for people living with eosinophilic gastrointestinal disorders.
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