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2011
Kalamarides M, Acosta MT, Babovic-Vuksanovic D, Carpen O, Cichowski K, Gareth Evans D, Giancotti F, Oliver Hanemann C, Ingram D, Lloyd AC, Mayes DA, Messiaen L, Morrison H, North K, Packer R, Pan D, Stemmer-Rachamimov A, Upadhyaya M, Viskochil D, Wallace MR, Hunter-Schaedle K, Ratner N. Neurofibromatosis 2011: a report of the Children's Tumor Foundation Annual Meeting. Acta Neuropathol. 2011.
Yang, J., Ylipää, A., Sun, Y., Zheng, H., Chen, C., Nykter, M., Trent, J., Ratner, N., Lev, D., and Zhang, W. Genomic and Molecular Characterization of Malignant Peripheral Nerve Sheath Tumor Identifies the IGF1R Pathway as a Primary Target for Treatment. Clin Cancer Res. 2011.
Wood M, Rawe M, Johansson G, Pang S, Soderquist RS, Patel AV, Nelson S, Seibel W, Ratner N, Sanchez Y. Discovery of a small molecule targeting IRA2 deletion in budding yeast and neurofibromin loss in malignant peripheral nerve sheath tumor cells. Mol Cancer Ther. Sep;10(9):1740-50. 2011.
Shang X, Cancelas JA, Li L, Guo F, Liu W, Johnson JF, Ficker A, Daria D, Geiger H, Ratner N, Zheng Y. R-Ras and Rac1 GTPase Crosstalk Regulates Hematopoietic Progenitor Cell Migration, Homing and Mobilization.Biol Chem. 2011 May 13.
Mayes DA, Rizvi TA, Cancelas JA, Kolasinski NT, Ciraolo GM, Stemmer-Rachamimov AO, Ratner N. Perinatal or Adult Nf1 Inactivation Using Tamoxifen-Inducible PlpCre Each Cause Neurofibroma Formation. Cancer Res. 2011 Jul 1;71(13):4675-85.
Wu J, Dombi E, Jousma E, Scott Dunn R, Lindquist D, Schnell BM, Kim MO, Kim A, Widemann BC, Cripe TP, Ratner N. Preclincial testing of Sorafenib and RAD001 in the Nf(flox/flox); DhhCre mouse model of plexiform neurofibroma using magnetic resonance imaging. Pediatr Blood Cancer. Feb, 2011.
2010
Ryan MA, Nattamai KJ, Xing E, Schleimer D, Daria D, Sengupta A, Köhler A, Liu W, Gunzer M, Jansen M, Ratner N, Le Cras TD, Waterstrat A, Van Zant G, Cancelas JA, Zheng Y, Geiger H. Pharmacological inhibition of EGFR signaling enhances G-CSF-induced hematopoietic stem cell mobilization. Nat Med. 16(10):1141-6. Oct, 2010.
Hummel TR, Jessen WJ, Miller SJ, Kluwe L, Mautner VF, Wallace MR, Lázaro C, Page GP, Worley PF, Aronow BJ, Schorry EK, Ratner N. Gene expression analysis identifies potential biomarkers of neurofibromatosis type 1 including adrenomedullin. Clin Cancer Res. 16(20):5048-57. Oct, 2010.
Bosco EE, Nakai Y, Hennigan RF, Ratner N, Zheng Y. NF2-deficient cells depend on the Rac1-canonical Wnt signaling pathway to promote the loss of contact inhibition of proliferation. Oncogene. Apr 29;29(17):2540-9. 2010.
Miller SJ, Lan Z, Hardiman A, Wu J, Kordich JJ, Patmore D, Hegde R, Cripe TP, Cancelas J, Collins M, Ratner N. Inhibition of Eyes Absent Homolog 4 expression induces malignant peripheral nerve sheath tumor necrosis. Oncogene. 2010.
2009
Miller, SJ, Jessen, WJ, Mehta, T, Hardiman, A, Sites, E, Kaiser, S, Jegga, A, Li, H, Upadhyaya, M, Giovannini, M, Muir, D, Wallace, MR, Lopez, E, Serra, E, Lazaro, C, Stemmer-Rachamimov, A, Page, G, Aronow, BJ, Ratner, N. Integrative genomic analyses of neurofibromatosis tumours identify SOX9 as biomarker and survival gene. EMBO Mol. Medicine, 1(4): 236-248. 2009.
Mahller Y, Williams J, Baird W, Mitton B, Grossheim J, Saeki Y, Cancelas J, Ratner N, Cripe T. Neuroblastoma cell lines contain pluripotent tumor initiating cells that are susceptible to a targeted oncolytic virus. PLoS ONE. 4(1):e4235, 1 – 10. 2009.
2008
Williams JP, Wu J, Mukouyama Y, Miller SC, Geiger H, Colbert MC, Cancelas JA, Ratner N.
Nf1 mutation expands an EGFR-dependent peripheral nerve progenitor that confers tumorigenic potential.
Cell Stem Cell, 3(6):658-69. 2008.
Johansson G, Mahller Y, Collins MH, Kim M-O, Nobukuni T, Perentesis JP, Cripe TP, Lane HA, Kozma S, Thomas G, Ratner N.
Effective In vivo targeting of the mammalian target of rapamycin pathway in malignant peripheral nerve sheath tumors.
Mol. Cancer Therapeutics. 7(5):1237-45. 2008.
Wu, J, Williams, JP, Rizvi, TA, Kordich, JJ, Witte, D, Meijer, D, Stemmer-Rachamimov, AO, Cancelas, JA, Ratner, N.
Plexiform and dermal neurofibromas and pigmentation are caused by Nf1 loss in desert hedgehog-expressing cells.
Cancer Cell, 13(2), 105–116. 2008.
Other Significant Publications
Monk KR, Wu J, Williams JP, Meinhardt BA, Fitzgerald ME, Filippi M, Ratner N. Mast cells can contribute to axon-glial dissociation and fibrosis in peripheral nerve. Neuron Glial Biology 3(3):233-44. 2007.
Mahller YY, Vaikunth SS, Currier MA, Miller SJ, Ripberger MC, Hsu Y, Mehrian-Shai R, Collins MH, Crombleholme TM, Ratner N, Cripe TP. Oncolytic HSV and erlotinib inhibit tumor growth and angiogenesis in a novel malignant peripheral nerve sheath tumor xenograft model. Molec. Therapy 15(2):279-286. 2007.
Nakai Y, Zheng Y, McCollin M, Ratner N. Temporal control of Rac in Schwann cell-axon interaction is disrupted in NF2-mutant schwannoma cells. J. Neurosci. 26(13):3390-5. 2006.
Wu J, Crimmins J, Monk K, Williams J, Fitzgerald M, Tedesco S, Ratner N. Perinatal epidermal growth factor receptor blockade prevents peripheral nerve disruption in a mouse model reminiscent of benign world health organization grade I neurofibroma. Am. J. Pathol. 168(5), 1686-1696. 2006.
Miller SJ, Rangwala F, Williams J, Kong S, Jegga A, Aronow B, Frahm S, Kluwe L, Mautner V, Upadhyaya M, Muir D, Wallace M, Hagen J, Quelle DE, Watson M, Perry A, Gutmann DH, Ratner N. Large-scale molecular comparison of human Schwann cells to malignant peripheral nerve sheath tumor cell lines and tissues. Cancer Research. 66(5):2584-91. 2006.
Mahller YY, Rangwala F, Ratner N, Cripe TP. Malignant peripheral nerve sheath tumors with high and low Ras-GTP are permissive for oncolytic herpes simplex virus mutants. Pediatric Blood and Cancer. 46(7):745-54. 2006.
