Projects | Mizuno Lab

Our Research Projects

Our research program conducts highly collaborative multidisciplinary clinical and translational research in applying the science of clinical pharmacology, pharmacometrics, pharmacogenetics, and systems pharmacology to develop and implement personalized precision dosing strategies in pediatric and adult patients. Our focused areas include oncology, immunology, inflammatory-related diseases, biologics medications, opioids, and infections. Our overarching goal is to improve health care by integrating quantitative modeling and simulation, digital twin technologies, and advanced analytical and bioinformatic technologies including biosensors and digital health.

Our lab actively collaborates with clinicians and basic and clinical scientists. Our collaborative research projects include:

Clinical Implementation of Model-Informed Precision Dosing (MIPD) in Pediatrics

The goal of precision dosing is to identify optimal dosing regimens that provide adequate therapeutic efficacy with minimal risk of toxicity for each individual patient. The MIPD framework provides a virtual platform to integrate various patient information, (e.g. body size, age, genetic background, and disease characteristics) to evaluate potential clinical scenarios to determine actionable dosing recommendations tailored to each patient’s needs. The MIPD approach also enables the utilization of clinical feedback such as blood concentrations and/or biomarkers to further individualize medications over the course of treatment. In collaboration with various clinicians and clinical scientists, our lab employs MIPD technologies to facilitate therapeutic optimization for various drugs and therapeutic areas, including mTOR inhibitors, anti-inflammatory biologics, immunosuppressive therapies, opioids, and neonatal opioid withdrawal syndrome (NOWS), and anti-infectious drugs.

Physiologically-Based Pharmacokinetics (PBPK) Modeling to Predict Drug Exposure in Pediatric and Maternal-Fetal Populations

PBPK is a mathematical modeling technique to describe drug behavior in the body (i.e. oral absorption, distribution to tissues, metabolisms, and eliminations) based on drug-specific physicochemical properties and patient’s physiology. Our lab utilizes PBPK technologies to predict drug disposition and exposure in support of optimal dose selections in special populations such as neonates and infants, children, pregnant women, and their fetuses.

Clinical Pharmacokinetics Consultation

We offer model-informed clinical pharmacokinetics (PK) consultation service providing real-time PK assessment and dose recommendations to achieve the pre-defined goal exposure as part of routine clinical care or prospective concentration-control clinical trials. We provide consultation for various drugs including mTOR inhibitors, anti-cancer drugs, immunosuppressive agents, anti-inflammatory biologics, psychiatric drugs, and anti-infective drugs.

Model-Informed Pediatric Drug Development (MIPDD)

As part of the Pharmacometrics Services, we provide strategic clinical pharmacology consulting, pediatric study design, and data analysis support by using our pharmacometrics and systems pharmacology research expertise. We utilize quantitative modeling and clinical trial simulations to evaluate potential clinical trial designs, extrapolate from adult clinical data to pediatric patients, identify age-appropriate pediatric dosing regimens, determine optimal sampling design, and estimate the required sample size. We have a track record of a portfolio of MIPDD projects in collaboration with bio-pharmaceutical industries and academic collaborators. Learn more about our Pharmacometrics Services at Cincinnati Children's.

Development of EHR-Integrated Clinical Decision Support Dashboards

The process of gathering clinical information, performing model-informed analyses and predictions, and translating simulated data to decision-support platforms is complex and time-consuming. User-friendly software integrated into electronic health record (EHR) systems is essential to widely disseminate the implementation of model-informed precision dosing at the bedside. As part of multidisciplinary teams at Cincinnati Children’s, we work together to develop EHR-integrated clinical decision support (CDS) platforms to help clinicians implement MIPD in the clinic.

Leveraging Artificial Intelligence (AI) and Machine Learning (ML) Technologies to Facilitate Precision Dosing in Children

Artificial intelligence (AI) is a discipline of computer science that focuses on creating systems that can perform tasks typically requiring human intelligence, such as understanding natural language, recognizing patterns, making decisions, and solving complex problems. Machine Learning (ML) is a subset of AI that focuses on the development of algorithms and statistical models that enable computer systems to learn from and make predictions or decisions based on data. Our lab is interested in applying AI and ML approaches to support pediatric dose selection and therapeutic optimization based on the prediction of drug exposure, adverse drug reactions, and clinical outcomes by integrating real-world clinical data. We are also interested in utilizing AI/ML approaches to streamline the process of a model-informed precision dosing system.

Meet the Lab