Mizuno Lab

Publications

van Hoogdalem, MW; Wexelblatt, SL; Akinbi, HT; Vinks, AA; Mizuno, T. A review of pregnancy-induced changes in opioid pharmacokinetics, placental transfer, and fetal exposure: Towards fetomaternal physiologically-based pharmacokinetic modeling to improve the treatment of neonatal opioid withdrawal syndrome. Pharmacology and Therapeutics. 2022; 234:108045.

Mizuno, T; Dong, M; Taylor, ZL; Ramsey, LB; Vinks, AA. Clinical implementation of pharmacogenetics and model-informed precision dosing to improve patient care. British Journal of Clinical Pharmacology. 2022; 88:1418-1426.

Colman, RJ; Xiong, Y; Mizuno, T; Hyams, JS; Noe, JD; Boyle, B; D’Haens, GR; van Limbergen, J; Chun, K; Yang, J; et al. Antibodies-to-infliximab accelerate clearance while dose intensification reverses immunogenicity and recaptures clinical response in paediatric Crohn's disease. Alimentary Pharmacology and Therapeutics. 2022; 55:593-603.

van Hoogdalem, MW; Johnson, TN; McPhail, BT; Kamatkar, S; Wexelblatt, SL; Ward, LP; Christians, U; Akinbi, HT; Vinks, AA; Mizuno, T. Physiologically-Based Pharmacokinetic Modeling to Investigate the Effect of Maturation on Buprenorphine Pharmacokinetics in Newborns with Neonatal Opioid Withdrawal Syndrome. Clinical Pharmacology and Therapeutics. 2022; 111:496-508.

Xiong, Y; Mizuno, T; Colman, R; Hyams, J; Noe, JD; Boyle, B; Tsai, YT; Dong, M; Jackson, K; Punt, N; et al. Real-World Infliximab Pharmacokinetic Study Informs an Electronic Health Record-Embedded Dashboard to Guide Precision Dosing in Children with Crohn's Disease. Clinical Pharmacology and Therapeutics. 2021; 109:1639-1647.

Bergan, S; Brunet, M; Hesselink, DA; Johnson-Davis, KL; Kunicki, PK; Lemaitre, F; Marquet, P; Molinaro, M; Noceti, O; Pattanaik, S; et al. Personalized Therapy for Mycophenolate: Consensus Report by the International Association of Therapeutic Drug Monitoring and Clinical Toxicology. Therapeutic Drug Monitoring. 2021; 43:150-200.

Mizuno, T; McPhail, BT; Kamatkar, S; Wexelblatt, S; Ward, L; Christians, U; Akinbi, HT; Vinks, AA. Physiologic Indirect Response Modeling to Describe Buprenorphine Pharmacodynamics in Newborns Treated for Neonatal Opioid Withdrawal Syndrome. Clinical Pharmacokinetics. 2021; 60:249-259.

van Hoogdalem, MW; McPhail, BT; Hahn, D; Wexelblatt, SL; Akinbi, HT; Vinks, AA; Mizuno, T. Pharmacotherapy of neonatal opioid withdrawal syndrome: a review of pharmacokinetics and pharmacodynamics. Expert Opinion on Drug Metabolism and Toxicology. 2021; 17:87-103.

Taylor, ZL; Mizuno, T; Punt, NC; Baskaran, B; Sainz, AN; Shuman, W; Felicelli, N; Vinks, AA; Heldrup, J; Ramsey, LB. MTXPK.org: A Clinical Decision Support Tool Evaluating High-Dose Methotrexate Pharmacokinetics to Inform Post-Infusion Care and Use of Glucarpidase. Clinical Pharmacology and Therapeutics. 2020; 108:635-643.

Vinks, AA; Punt, NC; Menke, F; Kirkendall, E; Butler, D; Duggan, TJ; Cortezzo, DE; Kiger, S; Dietrich, T; Spencer, P; et al. Electronic Health Record-Embedded Decision Support Platform for Morphine Precision Dosing in Neonates. Clinical Pharmacology and Therapeutics. 2020; 107:186-194.

Brunet, M; van Gelder, T; Asberg, A; Haufroid, V; Hesselink, DA; Langman, L; Lemaitre, F; Marquet, P; Seger, C; Shipkova, M; et al. Therapeutic Drug Monitoring of Tacrolimus-Personalized Therapy: Second Consensus Report. Therapeutic Drug Monitoring. 2019; 41:261-307.

Mizuno, T; O'Brien, MM; Vinks, AA. Significant effect of infection and food intake on sirolimus pharmacokinetics and exposure in pediatric patients with acute lymphoblastic leukemia. European Journal of Pharmaceutical Sciences. 2019; 128:209-214.

Mizuno, T; Emoto, C; Fukuda, T; Hammill, AM; Adams, DM; Vinks, AA. Model-based precision dosing of sirolimus in pediatric patients with vascular anomalies. European Journal of Pharmaceutical Sciences. 2017; 109S:S124-S131.

Mizuno, T; Fukuda, T; Emoto, C; Mobberley-Schuman, PS; Hammill, AM; Adams, DM; Vinks, AA. Developmental pharmacokinetics of sirolimus: Implications for precision dosing in neonates and infants with complicated vascular anomalies. Pediatric Blood and Cancer. 2017; 64.

Shimamoto, Y; Fukushima, K; Mizuno, T; Ichikawa, H; Kurosaki, K; Maeda, S; Okuda, M. Model-Informed Vancomycin Dosing Optimization to Address Delayed Renal Maturation in Infants and Young Children with Critical Congenital Heart Disease. Clinical Pharmacology and Therapeutics. 2024; 115:239-247.

Paice, K; Tang Girdwood, S; Pavia, K; Mizuno, T; Kaplan, J. 868: EARLY MEROPENEM CLEARANCE OF CRITICALLY ILL PATIENTS IN A PEDIATRIC INTENSIVE CARE UNIT. Critical Care Medicine. 2024; 52:s407.

Taylor, ZL; Poweleit, EA; Paice, K; Somers, KM; Pavia, K; Vinks, AA; Punt, N; Mizuno, T; Girdwood, ST. Tutorial on model selection and validation of model input into precision dosing software for model-informed precision dosing. CPT: Pharmacometrics and Systems Pharmacology. 2023; 12:1827-1845.

Cervantes, FC; Mizuno, T; Dong, M; Tang, P; Arbough, T; Vinks, AA; Kaplan, JM; Girdwood, SC T. Ceftriaxone Pharmacokinetics and Pharmacodynamics in 2 Pediatric Patients on Extracorporeal Membrane Oxygenation Therapy. Therapeutic Drug Monitoring. 2023; 45:832-836.

Poweleit, EA; Taylor, ZL; Mizuno, T; Vaughn, SE; Desta, Z; Strawn, JR; Ramsey, LB. Escitalopram and Sertraline Population Pharmacokinetic Analysis in Pediatric Patients. Clinical Pharmacokinetics. 2023; 62:1621-1637.

Alghamdi, A; Seay, S; Hooper, DK; Varnell, CD; Darland, L; Mizuno, T; Lazear, D; Ramsey, LB. Tacrolimus pharmacokinetics are influenced by CYP3A5, age, and concomitant fluconazole in pediatric kidney transplant patients. Clinical and Translational Science. 2023; 16:1768-1778.

Pavia, K; Hambrick, HR; Paice, K; Tang, P; Punt, N; Kaplan, J; Goldstein, SL; Vinks, AA; Mizuno, T; Tang Girdwood, S. Cefepime pharmacokinetics in critically ill children and young adults undergoing continuous kidney replacement therapy. Journal of Antimicrobial Chemotherapy. 2023; 78:2140-2147.

Colman, RJ; Samuels, A; Mizuno, T; Punt, N; Vinks, AA; Minar, P. Model-informed Precision Dosing for Biologics Is Now Available at the Bedside for Patients With Inflammatory Bowel Disease. Inflammatory Bowel Diseases. 2023; 29:1342-1346.

Miyagawa, B; Lazear, D; Hooper, DK; Vinks, AA; Mizuno, T. Model-Informed Estimation of Acutely Decreased Tacrolimus Clearance and Subsequent Dose Individualization in a Pediatric Renal Transplant Patient With Posterior Reversible Encephalopathy Syndrome. Therapeutic Drug Monitoring. 2023; 45:376-382.

Samuels, A; Punt, N; Mizuno, T; Vinks, AA; Minar, PP. 347 DISEASE PROGRESSION PHARMACOKINETIC MODELING IMPROVES THE ACCURACY OF EARLY INFLIXIMAB CONCENTRATION TARGETS. Gastroenterology. 2023; 164:s-59.

Whaley, KG; Xiong, Y; Karns, R; Hyams, JS; Kugathasan, S; Boyle, BM; Walters, TD; Kelsen, J; LeLeiko, N; Shapiro, J; et al. Multicenter Cohort Study of Infliximab Pharmacokinetics and Therapy Response in Pediatric Acute Severe Ulcerative Colitis. Clinical Gastroenterology and Hepatology. 2023; 21:1338-1347.

Rosen, MJ; Rabizadeh, S; Panetta, JC; Mizuno, T; Vinks, AA; Whaley, KG; Hyams, JS; Kugathasan, S; Boyle, BM; Walters, TD; et al. 714 INFLIXIMAB CLEARANCE IN RELATION TO DISEASE ACTIVITY DURING INDUCTION AND MAINTENANCE THERAPY OF ACUTE SEVERE AND AMBULATORY PEDIATRIC ULCERATIVE COLITIS. Gastroenterology. 2023; 164:s-150.

Poweleit, EA; Vinks, AA; Mizuno, T. Artificial Intelligence and Machine Learning Approaches to Facilitate Therapeutic Drug Management and Model-Informed Precision Dosing. Therapeutic Drug Monitoring. 2023; 45:143-150.

Colman, RJ; Mizuno, T; Fukushima, K; Haslam, DB; Hyams, JS; Boyle, B; Noe, JD; D'Haens, GR; Van Limbergen, J; Chun, K; et al. Real world population pharmacokinetic study in children and young adults with inflammatory bowel disease discovers novel blood and stool microbial predictors of vedolizumab clearance. Alimentary Pharmacology and Therapeutics. 2023; 57:524-539.

Pavia, K; Girdwood, ST; Paice, K; Jones, R; Curry, C; Stoneman, E; Yunger, T; Gamel, N; Gibson, A; Dong, M; et al. 610: RENAL IMPAIRMENT IS ASSOCIATED WITH HIGH CEFEPIME CONCENTRATIONS IN CRITICALLY ILL CHILDREN. Critical Care Medicine. 2023; 51:294.

Paice, K; Girdwood, ST; Pavia, K; Mizuno, T; Tang, P; Curry, C; Gibson, A; Jones, R; Stoneman, E; Yunger, T; et al. 38: CRITICALLY ILL CHILDREN WITH SEVERE SEPSIS OFTEN HAVE SUB-TARGET MEROPENEM LEVELS EARLY IN THERAPY. Critical Care Medicine. 2023; 51:19.

Hirabatake, M; Mizuno, T; Kato, H; Hashida, T. Everolimus pharmacokinetics and exposure-response relationship in Japanese patients with advanced breast cancer. Frontiers in Pharmacology. 2022; 13:984002.

van Hoogdalem, MW; Wexelblatt, SL; Akinbi, HT; Vinks, AA; Mizuno, T. A review of pregnancy-induced changes in opioid pharmacokinetics, placental transfer, and fetal exposure: Towards fetomaternal physiologically-based pharmacokinetic modeling to improve the treatment of neonatal opioid withdrawal syndrome. Pharmacology and Therapeutics. 2022; 234:108045.

Mizuno, T; Dong, M; Taylor, ZL; Ramsey, LB; Vinks, AA. Clinical implementation of pharmacogenetics and model-informed precision dosing to improve patient care. British Journal of Clinical Pharmacology. 2022; 88:1418-1426.

Colman, RJ; Xiong, Y; Mizuno, T; Hyams, JS; Noe, JD; Boyle, B; D’Haens, GR; van Limbergen, J; Chun, K; Yang, J; et al. Antibodies-to-infliximab accelerate clearance while dose intensification reverses immunogenicity and recaptures clinical response in paediatric Crohn's disease. Alimentary Pharmacology and Therapeutics. 2022; 55:593-603.

Minar, P; Samuels, A; Mizuno, T; Menke, F; Vogt, A; Punt, N; Vinks, A. BIOLOGIC PRECISION DOSING IS NOW AVAILABLE AT THE BEDSIDE FOR CHILDREN AND ADULTS WITH INFLAMMATORY BOWEL DISEASE RECEIVING INFLIXIMAB. Gastroenterology. 2022; 162:s98-s99.

van Hoogdalem, MW; Johnson, TN; McPhail, BT; Kamatkar, S; Wexelblatt, SL; Ward, LP; Christians, U; Akinbi, HT; Vinks, AA; Mizuno, T. Physiologically-Based Pharmacokinetic Modeling to Investigate the Effect of Maturation on Buprenorphine Pharmacokinetics in Newborns with Neonatal Opioid Withdrawal Syndrome. Clinical Pharmacology and Therapeutics. 2022; 111:496-508.

Samuels, A; Punt, N; Reifenberg, J; Mizuno, T; Colman, R; Menke, F; Vogt, A; Vinks, A; Minar, P. PREDICTIVE PERFORMANCE OF DIFFERENT POPULATION PHARMACOKINETIC MODELS IN A REAL-WORLD COHORT OF CROHN’S DISEASE PATIENTS. Gastroenterology. 2022; 162:s99-s100.

Colman, R; Mizuno, T; Hyams, J; Noe, J; Boyle, B; Denson, L; Vinks, A; Minar, P. REAL-WORLD VEDOLIZUMAB PHARMACOKINETIC STUDY IN CHILDREN IDENTIFIES TWO NOVEL BIOMARKERS OF DRUG CLEARANCE. Gastroenterology. 2022; 162:s100.

Samuels, A; Punt, N; Reifenberg, J; Mizuno, T; Colman, R; Menke, F; Vogt, A; Vinks, A; Minar, P. PREDICTIVE PERFORMANCE OF DIFFERENT POPULATION PHARMACOKINETIC MODELS IN A REAL-WORLD COHORT OF CROHN’S DISEASE PATIENTS. Inflammatory Bowel Diseases. 2022; 28:s99-s100.

Colman, R; Mizuno, T; Hyams, J; Noe, J; Boyle, B; Denson, L; Vinks, A; Minar, P. REAL-WORLD VEDOLIZUMAB PHARMACOKINETIC STUDY IN CHILDREN IDENTIFIES TWO NOVEL BIOMARKERS OF DRUG CLEARANCE. Inflammatory Bowel Diseases. 2022; 28:s100.

Minar, P; Samuels, A; Mizuno, T; Menke, F; Vogt, A; Punt, N; Vinks, A. BIOLOGIC PRECISION DOSING IS NOW AVAILABLE AT THE BEDSIDE FOR CHILDREN AND ADULTS WITH INFLAMMATORY BOWEL DISEASE RECEIVING INFLIXIMAB. Inflammatory Bowel Diseases. 2022; 28:s98-s99.

Taylor, ZL; Thompson, LE; Bear, H; Mizuno, T; Vinks, AA; Ramsey, LB. Toward pharmacogenetic SLCO1B1-guided dosing of methotrexate in arthritis using a murine Slco1b2 knockout model. Clinical and Translational Science. 2021; 14:2267-2277.

Shimamoto, Y; Verstegen, RH J; Mizuno, T; Schechter, T; Allen, U; Ito, S. Population pharmacokinetics of vancomycin in paediatric patients with febrile neutropenia and augmented renal clearance: development of new dosing recommendations. Journal of Antimicrobial Chemotherapy. 2021; 76:2932-2940.

Xiong, Y; Mizuno, T; Colman, R; Hyams, J; Noe, JD; Boyle, B; Tsai, YT; Dong, M; Jackson, K; Punt, N; et al. Real-World Infliximab Pharmacokinetic Study Informs an Electronic Health Record-Embedded Dashboard to Guide Precision Dosing in Children with Crohn's Disease. Clinical Pharmacology and Therapeutics. 2021; 109:1639-1647.

Bergan, S; Brunet, M; Hesselink, DA; Johnson-Davis, KL; Kunicki, PK; Lemaitre, F; Marquet, P; Molinaro, M; Noceti, O; Pattanaik, S; et al. Personalized Therapy for Mycophenolate: Consensus Report by the International Association of Therapeutic Drug Monitoring and Clinical Toxicology. Therapeutic Drug Monitoring. 2021; 43:150-200.

Sebold, AJ; Day, AM; Ewen, J; Adamek, J; Byars, A; Cohen, B; Kossoff, EH; Mizuno, T; Ryan, M; Sievers, J; et al. Sirolimus Treatment in Sturge-Weber Syndrome. Pediatric Neurology. 2021; 115:29-40.

Wright, KD; Yao, X; London, WB; Kao, PC; Gore, L; Hunger, S; Geyer, R; Cohen, KJ; Allen, JC; Katzenstein, HM; et al. A POETIC Phase II study of continuous oral everolimus in recurrent, radiographically progressive pediatric low-grade glioma. Pediatric Blood and Cancer. 2021; 68:e28787.

Mizuno, T; McPhail, BT; Kamatkar, S; Wexelblatt, S; Ward, L; Christians, U; Akinbi, HT; Vinks, AA. Physiologic Indirect Response Modeling to Describe Buprenorphine Pharmacodynamics in Newborns Treated for Neonatal Opioid Withdrawal Syndrome. Clinical Pharmacokinetics. 2021; 60:249-259.

van Hoogdalem, MW; McPhail, BT; Hahn, D; Wexelblatt, SL; Akinbi, HT; Vinks, AA; Mizuno, T. Pharmacotherapy of neonatal opioid withdrawal syndrome: a review of pharmacokinetics and pharmacodynamics. Expert Opinion on Drug Metabolism and Toxicology. 2021; 17:87-103.

Chen, Y; Sun, L; Xu, H; Dong, M; Mizuno, T; Vinks, AA; Brunner, HI; Li, Y; Li, Z. PK/PD Study of Mycophenolate Mofetil in Children With Systemic Lupus Erythematosus to Inform Model-Based Precision Dosing. Frontiers in Pharmacology. 2020; 11:605060.

Ullrich, NJ; Prabhu, SP; Reddy, AT; Fisher, MJ; Packer, R; Goldman, S; Robison, NJ; Gutmann, DH; Viskochil, DH; Allen, JC; et al. A phase II study of continuous oral mTOR inhibitor everolimus for recurrent, radiographic-progressive neurofibromatosis type 1-associated pediatric low-grade glioma: a Neurofibromatosis Clinical Trials Consortium study. Neuro-Oncology. 2020; 22:1527-1535.

Girdwood, ST; Arbough, T; Dong, M; Mizuno, T; Tang, P; Vinks, AA; Kaplan, J. Molecular Adsorbent Recirculating System Therapy with Continuous Renal Replacement Therapy Enhanced Clearance of Piperacillin in a Pediatric Patient and Led to Failure to Attain Pharmacodynamic Targets. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy. 2020; 40:1061-1068.

Euteneuer, JC; Mizuno, T; Fukuda, T; Zhao, J; Setchell, KD R; Muglia, LJ; Vinks, AA. Model-Informed Bayesian Estimation Improves the Prediction of Morphine Exposure in Neonates and Infants. Therapeutic Drug Monitoring. 2020; 42:778-786.

Taylor, ZL; Mizuno, T; Punt, NC; Baskaran, B; Sainz, AN; Shuman, W; Felicelli, N; Vinks, AA; Heldrup, J; Ramsey, LB. MTXPK.org: A Clinical Decision Support Tool Evaluating High-Dose Methotrexate Pharmacokinetics to Inform Post-Infusion Care and Use of Glucarpidase. Clinical Pharmacology and Therapeutics. 2020; 108:635-643.

Hahn, D; Fukuda, T; Euteneuer, JC; Mizuno, T; Vinks, AA; Sadhasivam, S; Emoto, C. Influence of MRP3 Genetics and Hepatic Expression Ontogeny for Morphine Disposition in Neonatal and Pediatric Patients. Journal of Clinical Pharmacology. 2020; 60:992-998.

van Hoogdalem, MW; Emoto, C; Fukuda, T; Mizuno, T; Mehta, PA; Vinks, AA. Population pharmacokinetic modelling of busulfan and the influence of body composition in paediatric Fanconi anaemia patients. British Journal of Clinical Pharmacology. 2020; 86:933-943.

Minar, PP; Xiong, Y; Mizuno, T; Colman, RJ; Hyams, JS; Noe, JD; Boyle, BM; Chun, KY; Yang, JM; Tsai, YT; et al. 1160 REAL-WORLD PEDIATRIC INFLIXIMAB PHARMACOKINETIC MODEL VERIFIES CRITICAL NEED FOR PRECISION DOSING SOFTWARE. Gastroenterology. 2020; 158:s-233-s-234.

Colman, RJ; Mizuno, T; Meryum, S; Vinks, AA; Minar, PP. Mo1895 POPULATION PHARMACOKINETIC BAYESIAN ESTIMATES AND VEDOLIZUMAB INDUCTION EXPOSURE PREDICT 1-YEAR STEROID-FREE CLINICAL REMISSION IN PEDIATRIC IBD. Gastroenterology. 2020; 158:s-967-s-968.

Colman, RJ; Xiong, Y; Mizuno, T; Hyams, JS; Noe, JD; Boyle, BM; Chun, KY; Yang, JM; Rosen, MJ; Denson, LA; et al. 613 ANTIBODIES TO INFLIXIMAB ACCELERATE DRUG CLEARANCE WHILE INTENSIFICATION STRATEGIES REVERSE IMMUNOGENICITY AND RECAPTURE CLINICAL RESPONSE. Gastroenterology. 2020; 158:s-130-s-131.

Bauman, LE; Xiong, Y; Mizuno, T; Minar, P; Fukuda, T; Dong, M; Rosen, MJ; Vinks, AA. Improved Population Pharmacokinetic Model for Predicting Optimized Infliximab Exposure in Pediatric Inflammatory Bowel Disease. Inflammatory Bowel Diseases. 2020; 26:429-439.

Emoto, C; Hahn, D; Euteneuer, JC; Mizuno, T; Vinks, AA; Fukuda, T. Next Challenge From the Variance in Individual Physiologically-Based Pharmacokinetic Model-Predicted to Observed Morphine Concentration in Critically Ill Neonates. Clinical Pharmacology and Therapeutics. 2020; 107:319-320.

Vinks, AA; Punt, NC; Menke, F; Kirkendall, E; Butler, D; Duggan, TJ; Cortezzo, DE; Kiger, S; Dietrich, T; Spencer, P; et al. Electronic Health Record-Embedded Decision Support Platform for Morphine Precision Dosing in Neonates. Clinical Pharmacology and Therapeutics. 2020; 107:186-194.

Wiles, JR; Isemann, B; Mizuno, T; Tabangin, ME; Ward, LP; Akinbi, H; Vinks, AA. Pharmacokinetics of Oral Methadone in the Treatment of Neonatal Abstinence Syndrome: A Pilot Study. The Journal of Pediatrics. 2020; 167:1214-20.e3.

Tang Girdwood, SC; Mizuno, T; Krallman, KA; Benken, LA; Stoneman, EM; Yunger, TM; Wong, HR; Vinks, AA; Kaplan, JM. Route of Oseltamivir Administration Affects Metabolite Concentrations in Critically Ill Children. The Pediatric Infectious Disease Journal. 2020; 38:1224-1227.

Emoto, C; Hahn, D; Euteneuer, J; Mizuno, T; Vinks, A; Fukuda, T. P212 - PBPK modeling and simulation of morphine in virtual neonates generated using actual patient information. Drug Metabolism and Pharmacokinetics. 2020; 35:s86-s87.

Arbough, T; Girdwood, ST; Mizuno, T; Tang, P; Vinks, S; Kaplan, J. 840: MOLECULAR ADSORBENT RECIRCULATING SYSTEM ALTERS PIPERACILLIN CLEARANCE IN PEDIATRIC LIVER FAILURE. Critical Care Medicine. 2020; 48:400.