Prasad Devarajan, MD
Title
Louise M. Williams Endowed Chair, Director of Nephrology and Hypertension
Appointment
Professor of Pediatrics and Developmental Biology
Email
prasad.devarajan@cchmc.org
Phone
513-636-4531
Fax
513-636-7407
Credentials
Premedical Studies: Bombay University, India, 1979
MD: Bombay University, India, 1985
Position History
1985-1986 Graduate Research, Dept of Physiology (Laboratory of Leon C. Moore, Ph.D.), SUNY Stony Brook, NY
1986-1989 Internship and Residency, Dept of Pediatrics, SUNY Stony Brook, NY
1989-1991 NIH Fellow, Pediatric Scientist Development Program, Hematology / Genetics, (Laboratory of Edward J. Benz, Jr., MD), Yale University School of Medicine, New Haven, Conn.
1991-1993 Postdoctoral Fellowship, Dept. of Pediatrics, Division of Nephrology, Yale University School of Medicine, New Haven, Conn.
1993-1995 Research Associate, Dept of Pathology and Cell Biology (Laboratory of Jon S. Morrow, MD, PhD), Yale University School of Medicine, New Haven, Conn.
1993-1994 Instructor, Dept of Pediatrics, Division of Nephrology, Yale University School of Medicine, New Haven, Conn.
1994-1998 Assistant Professor, Dept of Pediatrics, Division of Nephrology, Yale University School of Medicine, New Haven, Conn.
1998-1999 Assistant Professor & Director of Research, Dept of Pediatrics, Division of Nephrology, Children's Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, NY
1999-2002 Associate Professor and Director of Research, Dept. of Pediatrics, Division of Nephrology, Children's Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, NY
July 2002 Williams Professor of Pediatrics and Developmental Biology, Director of Nephrology and Hypertension, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio.
Awards and Honors
Best Doctors in America, 2008
Awarded "2005 Best Doctors"
1988-present Reviewer:
New England Journal of Medicine
Lancet
Journal of Cell Biology,
Journal of Biological Chemistry,
Pediatrics,
Journal of Pediatrics,
American Journal of Physiology,
Journal of American Society of Nephrology,
Pediatric Nephrology,
Kidney International,
Transplantation,
American Journal of Transplantation,
American Journal of Kidney Disease
1992-present Member, SPR, ASPN, ASN, NKF, AHA Council on Kidney in Cardiovascular Disease
2000-present External Reviewer, NIH/NIDDK, Special Emphasis Review Panels
2001-present Ad Hoc Reviewer, NIH/NIDDK, Study Sections
2001-present Associate Editor, American Journal of Physiology (Cell Physiology)
2002-present Member, American Society for Pediatric Nephrology Research Council
2003-present Associate Editor, Pediatric Nephrology
2004-present ASPN representative, Acute Kidney Injury Network
2005-present Member, Acute Renal Failure Advisory Committee, ASN
Research Grants and Contracts
T32DK007695 Devarajan (PI) 07/01/07-06/30/12
NIH/NIDDK
Research Training in Pediatric Nephrology This is the NIH training grant for fellows in Nephrology
Translational Research Devarajan (PI) 07/01/08-06/30/09
Children's Hospital Medical Center
A Novel Urinary Biomarker Panel For Lupus Nephritis This proposal is to identify and validate novel biomarker panels for the prediction of lupus nephritis severity and flares.
DK RO1 DK069749 Devarajan (PI) 04/01/05-03/31/10
NIH/NIDDK
Implications of the ASK1/JNK pathway in ARF
This proposal examines the role of ASK1/JNK signal transduction pathway in acute renal failure
W81XWH0710322 Devarajan (PI) 06/01/07-05/31/10
Department of Defense
Early Prediction Of Lupus Nephritis Using Advanced Proteomics
The objective is to identify and subsequently develop high-quality biomarkers of SLE for use in clinical practice and research.
R01 HL08676 Devarajan (center PI) 06/01/07-05/31/12 NIH/NHLBI Biomarkers of Acute Kidney Injury following Cardiac Surgery This proposal seeks to validate NGAL, cystatin C and IL-18 as biomarkers of renal injury after cardiac surgery.
U01 DK082185 Devarajan (center PI) 09/01/08-08/30/13 NIH/NIDDK Progression of Acute Kidney Injury to Chronic Kidney Disease This proposal seeks to determine the composite risk of ESRD and mortality in patients after acute kidney injury and to evaluate the prognostic value of elevations in serum cystatin C and urinary biomarker concentrations (IL-18, NGAL) for the future development of ESRD and mortality.
Publications, Most Recent
Prasad Devarajan's publications as listed by PubMed
Mori K, Lee HT, Rapoport D, Drexler I, Foster K, Yang J, Schmidt-Ott, Chen X, Li JY, Weiss S, Mishra J, Cheema FH, Markowitz G, Suganami T, Sawai K, Mukoyama M, Kunis C, D’Agati V, Devarajan P, Barasch J. Endocytic delivery of lipocalin-siderophore-iron complex rescues the kidney from ischemia-reperfusion injury. J Clin Invest 115:610–621, 2005
Mishra J, Dent C, Tarabishi R, Mitsnefes MM, Ma Q, Kelly C, Ruff SM, Zahedi K, Shao M, Bean J, Mori K, Barasch J, Devarajan P. Neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for acute renal injury following cardiac surgery. Lancet 365:1231-1238, 2005
Nguyen M, Ross G, Dent C, Devarajan P. Early prediction of acute renal injury using urinary proteomics. Am J Nephrol, 25:318-326, 2005
Tarabishi R, Zahedi K, Mishra J, Ma Q, Devarajan P. Induction of Zf9 in the kidney following early ischemia-reperfusion. Kidney International, 68:1511-1519, 2005
Devarajan P. Update on mechanisms of ischemic acute kidney injury. J Am Soc Nephrol 17:1503-1520, 2006
Parikh CR, Jani A, Mishra J, Ma Q, Kelly C, Barasch J, Edelstein CL, Devarajan P. Urine NGAL and IL-18 are predictive biomarkers for DGF following kidney transplantation. Am J Transplant 6:1639-1645, 2006
Parikh CR, Mishra J, Thiessen-Philbrook H, Dursun B, Ma Q, Kelly C, Dent C, Devarajan P, Edelstein CL. Urinary IL-18 is an early predictive biomarker of acute kidney injury after cardiac surgery. Kidney Int 70:199-203, 2006
Brunner HI, Mueller M, Rutherford C, Passo MH, Witte D, Grom A, Mishra J, Devarajan P. Urinary NGAL as a biomarker of nephritis in childhood-onset SLE. Arthritis and Rheumatism 54:2577-2584, 2006
Mitsnefes M, Kathman T, Mishra J, Kartal J, Khoury P, Nickolas T, Barasch J, Devarajan P. Serum NGAL as a marker of renal function in children with chronic kidney disease. Pediatr Nephrol 22:101-108, 2007
Devarajan P. Proteomics for biomarker discovery in acute kidney injury. Semin Nephrol, 27:637-651, 2007
Hirsch R, Dent C, Pfriem H, Allen J, Beekman RH, Ma Q, Bennett M, Mitsnefes M, Devarajan P. NGAL is an early predictive biomarker of contrast-induced nephropathy in children. Pediatr Nephrol, 22:2089-2095, 2007
Dent CL, Ma Q, Dastrala S, Bennett M, Mitsnefes MM, Barasch J, Devarajan P. Plasma NGAL predicts acute kidney injury, morbidity and mortality after pediatric cardiac surgery: a prospective uncontrolled cohort study. Crit Care 11(6):R127, 2007
Devarajan P, Parikh C, Barasch J. Case 31-2007: a man with abdominal pain and elevated creatinine. N Engl J Med. 358(3):312, 2008
Portilla D, Dent C, Sugaya T, Nagothu KK, Kundi I, Moore P, Noiri E, Devarajan P. Liver fatty acid-binding protein as a biomarker of acute kidney injury after cardiac surgery. Kidney Int. 73(4):465-72, 2008
Devarajan P. Proteomics for the investigation of acute kidney injury. Contrib Nephrol 160:1-16, 2008
Bennett M, Dent CL, Ma Q, Dastrala S, Grenier F, Workman R, Syed H, Ali S, Barasch J, Devarajan P. Urine NGAL Predicts Severity of Acute Kidney Injury After Cardiac Surgery: A Prospective Study. Clin J Am Soc Nephrol 3(3):665-673, 2008
Related Areas
This person works in these other areas at Cincinnati Children's Hospital Medical
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