About

Biography

As a clinical and translational scientist, I know I’m not alone in my desire to make a difference in people’s lives and find treatments that work. But, as a doctor and researcher focused on childhood rheumatic diseases, I feel especially motivated toward these goals. That’s because these conditions can be extremely painful and leave lasting, disabling effects on children.

Here at Cincinnati Children’s, I lead the Division of Rheumatology where we integrate clinical and translational research into daily care. My research work is made even more meaningful by interactions with the children and families I meet and serve in clinic, at our Lupus Center and within our lupus support groups.

I can trace my clinical and research interests back to a position I held during my medical training at Ludwig Maximillian University in Munich, Germany. There, I was part of a laboratory studying human leukocyte antigen (HLA) and its impact on transplanted tissue. I became fascinated with HLA’s role in regulating the immune system, and this early scientific experience set the tone for my career.

My research at Cincinnati Children’s is focused on the development of clinical trial endpoints, surrogate measures and biomarkers as they pertain to pediatric rheumatic diseases, particularly lupus. My colleagues and I conduct clinical trials in pediatric rheumatic disease, drug development, and biomarker discovery for lupus nephritis and lupus that affects the brain.

As part of my investigator-initiated research, I have successfully conducted several large multinational studies to develop flare, improvement, remission and inactive disease criteria for children with lupus.

I serve as the scientific director of the Pediatric Rheumatology Collaborative Study Group, where I work alongside researchers at more than 80 academic centers across the U.S. and Canada. As part of this network I design and conduct clinical trials to test new medications for the treatment of children with rheumatic diseases.

I find it fulfilling to be a part of many professional organizations related to pediatric rheumatic diseases and pediatric research. Our division is home to the Pediatric Rheumatology Clinical Outcome & Improvement Network (PCOIN), a multicenter learning network focused on connecting research and clinical care. My personal affiliations include the Childhood Arthritis and Rheumatology and Research Alliance, and the American College of Rheumatology.

I am committed to make our division excel in research, education, training and quality-driven patient-centered clinical care. This commitment has been recognized by such honors as the Castle Connolly Regional Top Doctor and Exceptional Women in Medicine awards (2017, 2018 and 2019), the Halsted R. Holman Award for Excellence in Clinical Research (2018) and the Above & Beyond Doctor of the Year award from the Aubrey Rose Foundation (2018).

MD: Ludwig Maximilan University, Munich, Germany, 1991.

Residency: University of Chicago, 1997.

Fellowship: University of Toronto & Cincinnati, 1999.

MSc: Clinical Epidemiology: University of Toronto, 1999.

Certification: Pediatrics 1997; Rheumatology, 2002.

Interests

Health-related quality of life; outcome research; lupus

Interests

Economic analyses; HRQOL; measurement development; outcome research; lupus

Additional Languages

German, Portuguese

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Publications

Physician's global assessment of disease activity in juvenile idiopathic arthritis: consensus-based recommendations from an international task force. Rypdal, V; Brunner, HI; Feldman, BM; Ruperto, N; Aggarwal, A; Angeles-Han, ST; Backström, M; Balay-Dustrude, E; Bracaglia, C; De Benedetti, F; Vojinovic, J; Weiss, PF; Gottlieb, B; Consolaro, A. Annals of the Rheumatic Diseases. 2025; 84:1425-1436.

New medicines for childhood-onset systemic lupus erythematosus: an EU perspective on paediatric drug development. De Lisa, R; de Andres-Trelles, F; Bax, R; Galluzzo, S; Alward, B; Thomson, A; Karres, D; Brunner, HI; Ruperto, N; Egger, GF. Frontiers in Medicine. 2025; 12:1583140.

Volumetric Absorptive Microsampling Combined with Mass Spectrometry to Support Pharmacokinetically-Guided Precision Dosing of Mycophenolate Mofetil in Pediatric Lupus Nephritis Patients. Zhao, J; Zhao, X; Mizuno, T; Irie, K; Devarajan, P; Brunner, HI; Setchell, KD R. The journal of applied laboratory medicine. 2025; 10:806-819.

Development and Validation of Multiplex Assays for Lupus Nephritis Activity Biomarkers. Cody, EM; Sproles, A; Rose, J; Huang, B; Devarajan, P; Brunner, HI; Thornton, S. Kidney International Reports. 2025; 10:2255-2264.

Infections preceding diagnosis associated with myositis phenotypes in a national patient registry. Ohnishi, T; Wilkerson, J; Bayat, N; Farhadi, PN; Faiq, A; Dillon, CF; Schiffenbauer, A; Parks, CG; Brunner, HI; Goldberg, B; Miller, FW; Rider, LG. Clinical and Experimental Rheumatology. 2025; 43:1204-1212.

ERN ReCONNET-SLICC-SLEuro expert consensus on the therapeutic management of rare systemic lupus erythematosus manifestations. Arnaud, L; Ruiz-Irastorza, G; Aranow, C; Bernatsky, S; Dall'Era, M; Adelowo, O; Bae, SC; Beretta, L; Bonfa, E; Cervera, R; Svenungsson, E; Tamirou, F; Tegzová, D; Tektonidou, MG. The Lancet. Rheumatology. 2025; 7:e505-e518.

OP0212 EFFICACY AND SAFETY OF TOFACITINIB IN PATIENTS WITH ACTIVE SYSTEMIC JUVENILE IDIOPATHIC ARTHRITIS. Ruperto, N; Li, C; Chinniah, K; Uziel, Y; Synoverska, O; Sawhney, S; Calvo, I; Louw, I; Lu, M; Patel, PN; Koch, GG; Martini, A; Lovell, DJ; Brunner, H. Annals of the Rheumatic Diseases. 2025; 84:176-177.

POS1172 EVALUATING THE STANDARDIZED STEROID REGIMEN (SSR) FOR CHILDHOOD-ONSET SYSTEMIC LUPUS ERYTHEMATOSUS: RETROSPECTIVE INSIGHTS FROM REAL-WORLD DATA. Kasap-Cuceoglu, M; Huggins, J; Ting, T; Smith-Rodriguez, J; Merritt, A; Brunner, H. Annals of the Rheumatic Diseases. 2025; 84:1242-1243.

POS0841 THE RENAL ACTIVITY INDEX FOR LUPUS IDENTIFIES AND PREDICTS COMPLETE RENAL REMISSION OR ABSENCE OF KIDNEY INVOLVEMENT IN SYSTEMIC LUPUS ERYTHEMATOSUS. Pons Estel, GJ; Quintana, R; Nieto, R; Brunner, H; Scolnik, M; Funes Soaje, C; Alba, P; Saurit, V; García, MA; Berbotto, G; Zazzetti, F; Orillion, A; Sbarigia, U; Pons-Estel, B. Annals of the Rheumatic Diseases. 2025; 84:985-986.

POS1400 PERIVENTRICULAR ABNORMALITY GRADIENTS OF RELAXOMETRY AND SUSCEPTIBILITY METRICS BY NEUROIMAGING: COMPARING LUPUS AND MULTIPLE SCLEROSIS. DiFrancesco, M; Wilson, E; Brunner, H. Annals of the Rheumatic Diseases. 2025; 84:1421-1422.

From the Blog

NIAMS-Funded Clinical Trial Featured on Lupus Foundation Podcast
Rheumatic Disorders

NIAMS-Funded Clinical Trial Featured on Lupus Foundation Podcast

Hermine I. Brunner, MD, MSc, MBA, Prasad Devarajan, MD2/9/2024

Tofacitinib Receives FDA Approval for Children with pcJIA
Autoimmune Disorders

Tofacitinib Receives FDA Approval for Children with pcJIA

Hermine I. Brunner, MD, MSc, MBA12/10/2020

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