As a clinical and translational scientist, I know I’m not alone in my desire to make a difference in people’s lives and find treatments that work. But, as a doctor and researcher focused on childhood rheumatic diseases, I feel especially motivated toward these goals. That’s because these conditions can be extremely painful and leave lasting, disabling effects on children.

Here at Cincinnati Children’s, I lead the Division of Rheumatology where we integrate clinical and translational research into daily care. My research work is made even more meaningful by interactions with the children and families I meet and serve in clinic, at our Lupus Center and within our lupus support groups.

I can trace my clinical and research interests back to a position I held during my medical training at Ludwig Maximillian University in Munich, Germany. There, I was part of a laboratory studying human leukocyte antigen (HLA) and its impact on transplanted tissue. I became fascinated with HLA’s role in regulating the immune system, and this early scientific experience set the tone for my career.

My research at Cincinnati Children’s is focused on the development of clinical trial endpoints, surrogate measures and biomarkers as they pertain to pediatric rheumatic diseases, particularly lupus. My colleagues and I conduct clinical trials in pediatric rheumatic disease, drug development, and biomarker discovery for lupus nephritis and lupus that affects the brain.

As part of my investigator-initiated research, I have successfully conducted several large multinational studies to develop flare, improvement, remission and inactive disease criteria for children with lupus.

I serve as the scientific director of the Pediatric Rheumatology Collaborative Study Group, where I work alongside researchers at more than 80 academic centers across the U.S. and Canada. As part of this network I design and conduct clinical trials to test new medications for the treatment of children with rheumatic diseases.

I find it fulfilling to be a part of many professional organizations related to pediatric rheumatic diseases and pediatric research. Our division is home to the Pediatric Rheumatology Clinical Outcome & Improvement Network (PCOIN), a multicenter learning network focused on connecting research and clinical care. My personal affiliations include the Childhood Arthritis and Rheumatology and Research Alliance, and the American College of Rheumatology.

I am committed to make our division excel in research, education, training and quality-driven patient-centered clinical care. This commitment has been recognized by such honors as the Castle Connolly Regional Top Doctor and Exceptional Women in Medicine awards (2017, 2018 and 2019), the Halsted R. Holman Award for Excellence in Clinical Research (2018) and the Above & Beyond Doctor of the Year award from the Aubrey Rose Foundation (2018).

Additional Languages

German, Portuguese

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Cross-cultural adaptation and initial validation of the Brazilian-Portuguese version of the pediatric automated neuropsychological assessment metrics. de Amorim, JC; Kishimoto, ST; Elorza, CL C; Cavaletti, FA; Marini, R; Silva, CA; Saad-Magalhães, C; Fernandes, PT; Brunner, HI; Appenzeller, S. Frontiers in Psychology. 2022; 13.

Secukinumab in enthesitis-related arthritis and juvenile psoriatic arthritis: a randomised, double-blind, placebo-controlled, treatment withdrawal, phase 3 trial. Brunner, HI; Foeldvari, I; Alexeeva, E; Ayaz, NA; Calvo Penades, I; Kasapcopur, O; Chasnyk, VG; Hufnagel, M; Zuber, Z; Schulert, G; et al. Annals of the Rheumatic Diseases. 2022.

Patient‐Reported Outcomes Among Patients Aged 2–17 Years With Polyarticular‐Course Juvenile Idiopathic Arthritis Treated With Subcutaneous Abatacept: 2‐Year Results From an International Phase III Study. Ruperto, N; Lovell, DJ; Berman, A; Ávila-Zapata, F; Horneff, G; Alessio, M; Becker, ML; Belot, A; Burgos-Vargas, R; Gamir, ML; et al. Arthritis Care and Research. 2022.

Treatment Guidelines in Pediatric Rheumatic Diseases. Ogbu, EA; Brunner, HI. Rheumatic Disease Clinics of North America. 2022; 48:725-746.

Stability of novel urinary biomarkers used for lupus nephritis. Cody, EM; Rose, JE; Huang, B; Qiu, T; Brunner, HI; Devarajan, P. Frontiers in Pediatrics. 2022; 10.

Children With Enthesitis-Related Arthritis and Possible Benefits From Treatments for Adults With Spondyloarthritis. Weiss, PF; Fuhlbrigge, RC; von Scheven, E; Lovell, DJ; Colbert, RA; Brunner, HI. Arthritis Care and Research. 2022; 74:1058-1064.

Prevention of disease flares by risk-adapted stratification of therapy withdrawal in juvenile idiopathic arthritis: results from the PREVENT-JIA trial. Gerss, J; Tedy, M; Klein, A; Horneff, G; Miranda-Garcia, M; Kessel, C; Holzinger, D; Stanevica, V; Swart, JF; Cabral, DA; et al. Annals of the Rheumatic Diseases. 2022; 81:990-997.

POS0340 PREDICTORS OF CLINICAL RESPONSE TO ABATACEPT IN CHILDREN WITH POLYARTICULAR JUVENILE IDIOPATHIC ARTHRITIS. Ruperto, N; Brunner, H; Berman, A; Avila Zapata, F; Horneff, G; Wagner-Weiner, L; Belot, A; Burgos-Vargas, R; Gámir Gámir, ML; Goldenstein-Schainberg, C; et al. Annals of the Rheumatic Diseases. 2022; 81:422.2-42423.

OP0221 EFFICACY OF SECUKINUMAB IN ENTHESITIS-RELATED ARTHRITIS: RESULTS FROM A RANDOMISED, DOUBLE-BLIND, PLACEBO-CONTROLLED, TREATMENT WITHDRAWAL, PHASE 3 STUDY (JUNIPERA). Ruperto, N; Chertok, E; Dehoorne, J; Horneff, G; Kallinich, T; Louw, I; Compeyrot-Lacassagne, S; Lauwerys, B; Martin, N; Marzan, K; et al. Annals of the Rheumatic Diseases. 2022; 81:145-146.

Tofacitinib for juvenile idiopathic arthritis - Authors' reply. Ruperto, N; Brunner, HI; Posner, HB; Lazariciu, I; Martini, A; Lovell, DJ. The Lancet. 2022; 399.

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