A photo of Hermine Brunner.

Director, Division of Rheumatology

Professor, UC Department of Pediatrics



Board Certified

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My Biography & Research


As a clinical and translational scientist, I know I’m not alone in my desire to make a difference in people’s lives and find treatments that work. But, as a doctor and researcher focused on childhood rheumatic diseases, I feel especially motivated toward these goals. That’s because these conditions can be extremely painful and leave lasting, disabling effects on children.

Here at Cincinnati Children’s, I lead the Division of Rheumatology where we integrate clinical and translational research into daily care. My research work is made even more meaningful by interactions with the children and families I meet and serve in clinic, at our Lupus Center and within our lupus support groups.

I can trace my clinical and research interests back to a position I held during my medical training at Ludwig Maximillian University in Munich, Germany. There, I was part of a laboratory studying human leukocyte antigen (HLA) and its impact on transplanted tissue. I became fascinated with HLA’s role in regulating the immune system, and this early scientific experience set the tone for my career.

My research at Cincinnati Children’s is focused on the development of clinical trial endpoints, surrogate measures and biomarkers as they pertain to pediatric rheumatic diseases, particularly lupus. My colleagues and I conduct clinical trials in pediatric rheumatic disease, drug development, and biomarker discovery for lupus nephritis and lupus that affects the brain.

As part of my investigator-initiated research, I have successfully conducted several large multinational studies to develop flare, improvement, remission and inactive disease criteria for children with lupus.

I serve as the scientific director of the Pediatric Rheumatology Collaborative Study Group, where I work alongside researchers at more than 80 academic centers across the U.S. and Canada. As part of this network I design and conduct clinical trials to test new medications for the treatment of children with rheumatic diseases.

I find it fulfilling to be a part of many professional organizations related to pediatric rheumatic diseases and pediatric research. Our division is home to the Pediatric Rheumatology Clinical Outcome & Improvement Network (PCOIN), a multicenter learning network focused on connecting research and clinical care. My personal affiliations include the Childhood Arthritis and Rheumatology and Research Alliance, and the American College of Rheumatology.

I am committed to make our division excel in research, education, training and quality-driven patient-centered clinical care. This commitment has been recognized by such honors as the Castle Connolly Regional Top Doctor and Exceptional Women in Medicine awards (2017, 2018 and 2019), the Halsted R. Holman Award for Excellence in Clinical Research (2018) and the Above & Beyond Doctor of the Year award from the Aubrey Rose Foundation (2018).

Additional Languages

German, Portuguese

Clinical Interests

Health-related quality of life; outcome research; lupus

Research Interests

Economic analyses; HRQOL; measurement development; outcome research; lupus

Academic Affiliation

Professor, UC Department of Pediatrics

Clinical Divisions

Rheumatology, Lupus

Research Divisions

Rheumatology, Global Health

Blog Posts

Tofacitinib Receives FDA Approval for Children with pcJIA

Autoimmune Disorders

Tofacitinib Receives FDA Approval for Children with pcJIA

Hermine I. Brunner, MD, MSc, MBA12/10/2020

My Locations

My Education

MD: Ludwig Maximilan University, Munich, Germany, 1991.

Residency: University of Chicago, 1997.

Fellowship: University of Toronto & Cincinnati, 1999.

MSc: Clinical Epidemiology: University of Toronto, 1999.

Certification: Pediatrics 1997; Rheumatology, 2002.

My Publications

Relationship Between Genetic Risk and Age of Diagnosis in Systemic Lupus Erythematosus. Dominguez, D; Kamphuis, S; Beyene, J; Wither, J; Harley, JB; Blanco, I; Vila-Inda, C; Brunner, H; Klein-Gitleman, M; McCurdy, D; et al. Journal of Rheumatology. 2021; 48:852-858.

Performance of the New 2019 European League Against Rheumatism/American College of Rheumatology Classification Criteria for Systemic Lupus Erythematosus in Children and Young Adults. Aljaberi, N; Nguyen, K; Strahle, C; Merritt, A; Mathur, A; Brunner, HI. Arthritis Care and Research. 2021; 73:580-585.

Prevalence of autoimmune diseases and other associated conditions in children and young adults with juvenile idiopathic arthritis. Lovell, DJ; Huang, B; Chen, C; Angeles-Han, ST; Simon, TA; Brunner, HI. RMD Open. 2021; 7.

Efficacy and Safety of Tocilizumab for Polyarticular-Course Juvenile Idiopathic Arthritis in the Open-Label Two-Year Extension of a Phase III Trial. Brunner, HI; Ruperto, N; Zuber, Z; Cuttica, R; Keltsev, V; Xavier, RM; Burgos-Vargas, R; Penades, IC; Silverman, ED; Espada, G; et al. Arthritis and Rheumatology. 2021; 73:530-541.

Tapering Canakinumab Monotherapy in Patients With Systemic Juvenile Idiopathic Arthritis in Clinical Remission: Results From a Phase IIIb/IV Open-Label, Randomized Study. Quartier, P; Alexeeva, E; Constantin, T; Chasnyk, V; Wulffraat, N; Palmblad, K; Wouters, C; I Brunner, H; Marzan, K; Schneider, R; et al. Arthritis and Rheumatology. 2021; 73:336-346.

Subcutaneous dosing regimens of tocilizumab in children with systemic or polyarticular juvenile idiopathic arthritis. Ruperto, N; Brunner, HI; Ramanan, AV; Horneff, G; Cuttica, R; Henrickson, M; Anton, J; Boteanu, AL; Penades, IC; Minden, K; et al. Rheumatology. 2021.

Open-Label Phase 3 Study of Intravenous Golimumab in Patients With Polyarticular Juvenile Idiopathic Arthritis. Ruperto, N; Brunner, HI; Pacheco-Tena, C; Louw, I; Vega-Cornejo, G; Spindler, AJ; Kingsbury, DJ; Schmeling, H; Borzutzky, A; Cuttica, R; et al. Rheumatology. 2021.

Immunomodulatory effects of cytokine-induced expansion of cytotoxic lymphocytes in a mouse model of lupus-like disease. Reighard, SD; Krishnamurthy, D; Cevik, H; Ochayon, DE; Ali, A; Seelamneni, H; Brunner, HI; Waggoner, SN. Cytotherapy. 2021; 23:37-45.

PK/PD Study of Mycophenolate Mofetil in Children With Systemic Lupus Erythematosus to Inform Model-Based Precision Dosing. Chen, Y; Sun, L; Xu, H; Dong, M; Mizuno, T; Vinks, AA; Brunner, HI; Li, Y; Li, Z. Frontiers in Pharmacology. 2020; 11.

Children with enthesitis-related arthritis could benefit from treatments targeted for adults with spondyloarthritis. Weiss, PF; Fuhlbrigge, RC; von Scheven, E; Lovell, DJ; Colbert, RA; Brunner, HI; PRCSG Advisory Council, the CARRA Executive Commit, . Arthritis Care and Research. 2020.