A photo of Hermine Brunner.

Director, Division of Rheumatology

Professor, UC Department of Pediatrics

513-636-6320

513-636-4116

Board Certified

My Biography & Research

Biography

As a clinical and translational scientist, I know I’m not alone in my desire to make a difference in people’s lives and find treatments that work. But, as a doctor and researcher focused on childhood rheumatic diseases, I feel especially motivated toward these goals. That’s because these conditions can be extremely painful and leave lasting, disabling effects on children.

Here at Cincinnati Children’s, I lead the Division of Rheumatology where we integrate clinical and translational research into daily care. My research work is made even more meaningful by interactions with the children and families I meet and serve in clinic, at our Lupus Center and within our lupus support groups.

I can trace my clinical and research interests back to a position I held during my medical training at Ludwig Maximillian University in Munich, Germany. There, I was part of a laboratory studying human leukocyte antigen (HLA) and its impact on transplanted tissue. I became fascinated with HLA’s role in regulating the immune system, and this early scientific experience set the tone for my career.

My research at Cincinnati Children’s is focused on the development of clinical trial endpoints, surrogate measures and biomarkers as they pertain to pediatric rheumatic diseases, particularly lupus. My colleagues and I conduct clinical trials in pediatric rheumatic disease, drug development, and biomarker discovery for lupus nephritis and lupus that affects the brain.

As part of my investigator-initiated research, I have successfully conducted several large multinational studies to develop flare, improvement, remission and inactive disease criteria for children with lupus.

I serve as the scientific director of the Pediatric Rheumatology Collaborative Study Group, where I work alongside researchers at more than 80 academic centers across the U.S. and Canada. As part of this network I design and conduct clinical trials to test new medications for the treatment of children with rheumatic diseases.

I find it fulfilling to be a part of many professional organizations related to pediatric rheumatic diseases and pediatric research. Our division is home to the Pediatric Rheumatology Clinical Outcome & Improvement Network (PCOIN), a multicenter learning network focused on connecting research and clinical care. My personal affiliations include the Childhood Arthritis and Rheumatology and Research Alliance, and the American College of Rheumatology.

I am committed to make our division excel in research, education, training and quality-driven patient-centered clinical care. This commitment has been recognized by such honors as the Castle Connolly Regional Top Doctor and Exceptional Women in Medicine awards (2017, 2018 and 2019), the Halsted R. Holman Award for Excellence in Clinical Research (2018) and the Above & Beyond Doctor of the Year award from the Aubrey Rose Foundation (2018).

Additional Languages

German, Portuguese

Clinical Interests

Health-related quality of life; outcome research; lupus

Research Interests

Economic analyses; HRQOL; measurement development; outcome research; lupus

Academic Affiliation

Professor, UC Department of Pediatrics

Divisions

Rheumatology, Lupus, Rheumatology, Global Health



Blog Posts

My Locations

My Education

MD: Ludwig Maximilan University, Munich, Germany, 1991.

Residency: University of Chicago, 1997.

Fellowship: University of Toronto & Cincinnati, 1999.

MSc: Clinical Epidemiology: University of Toronto, 1999.

Certification: Pediatrics 1997; Rheumatology, 2002.

My Publications

Therapeutic Targeting of Follicular T Cells with Chimeric Antigen Receptor-Expressing Natural Killer Cells. Reighard, SD; Cranert, SA; Rangel, KM; Ali, A; Gyurova, IE; de la Cruz-Lynch, AT; Tuazon, JA; Khodoun, MV; Kottyan, LC; Smith, DF; et al. 2020; 1:100003-100003.

Timing matters: Real-world effectiveness of early combination of biologic and conventional synthetic disease-modifying antirheumatic drugs for treating newly diagnosed polyarticular course juvenile idiopathic arthritis. Huang, B; Qiu, T; Chen, C; Zhang, Y; Seid, M; Lovell, D; Brunner, HI; Morgan, EM; PCATS, . RMD Open. 2020; 6:e001091-e001091.

Comparative Effectiveness Research using Electronic Health Records Data: Ensure Data Quality. Huang, B; Qiu, T; Chen, C; Neace, A; Zhang, Y; Yue, XM; Zahner, J; Adams, M; Seid, M; Lovell, D; et al. Sage. 2020.

Development and pilot testing of the treatment and education approach for childhood-onset lupus (TEACH): a cognitive behavioral treatment. Cunningham, NR; Fussner, LM; Moorman, E; Aydin, PO A; Brunner, HI; Kashikar-Zuck, S. Pediatric Rheumatology Online Journal. 2019; 17.

Immunome perturbation is present in patients with juvenile idiopathic arthritis who are in remission and will relapse upon anti-TNFα withdrawal. Leong, JY; Chen, P; Yeo, JG; Ally, F; Chua, C; Hazirah, SN; Poh, SL; Pan, L; Lai, L; Lee, ES C; et al. Annals of the Rheumatic Diseases. 2019; 78:1712-1721.

Systemic Juvenile Idiopathic Arthritis-Associated Lung Disease: Characterization and Risk Factors. Schulert, GS; Yasin, S; Carey, B; Chalk, C; Do, T; Schapiro, AH; Husami, A; Watts, A; Brunner, HI; Huggins, J; et al. Arthritis and Rheumatology. 2019; 71:1943-1954.

Glucocorticoids pharmacology and their application in the treatment of childhood-onset systemic lupus erythematosus. Deng, J; Chalhoub, NE; Sherwin, CM; Li, C; Brunner, HI. Seminars in Arthritis and Rheumatism. 2019; 49:251-259.

Neutropenia During Tocilizumab Treatment Is Not Associated with Infection Risk in Systemic or Polyarticular-course Juvenile Idiopathic Arthritis. Pardeo, M; Wang, J; Ruperto, N; Alexeeva, E; Chasnyk, V; Schneider, R; Horneff, G; Huppertz, H; Minden, K; Onel, K; et al. The Journal of rheumatology. 2019; 46:1117-1126.

Update on the treatment and outcome of systemic lupus erythematous in children. Rodriguez-Smith, J; Brunner, HI. Current Opinion in Rheumatology. 2019; 31:464-470.

Establishing an Updated Core Domain Set for Studies in Juvenile Idiopathic Arthritis: A Report from the OMERACT 2018 JIA Workshop. Morgan, EM; Munro, JE; Horonjeff, J; Horgan, B; Shea, B; Feldman, BM; Clairman, H; III, BC O; Thornhill, S; Strand, V; et al. The Journal of rheumatology. 2019; 46:1006-1013.