A photo of Stephen Waggoner.

Assistant Professor, UC Department of Pediatrics


About Me


Stephen Waggoner, PhD, is an assistant professor in the Center for Autoimmune Genomics and Etiology (CAGE) within the Division of Rheumatology at Cincinnati Children's Hospital Medical Center within the UC Department of Pediatrics. Dr. Waggoner received his PhD from the University of Virginia, conducted postdoctoral research at the University of Massachusetts Medical School, and joined the faculty at Cincinnati Children’s in 2013. He has garnered international recognition for his discovery that natural killer (NK) cells play a crucial regulatory role during persistent virus infection involving suppression of virus-specific T cell responses. His lab continues to explore the relevance of this phenomenon to chronic infection, vaccine efficacy, autoimmune disease, and age-associated immune dysfunction.

Research Interests

Viral immunology; natural killer cells; immunoregulation; vaccines; autoimmunity; immune dysfunction in aging.

Academic Affiliation

Assistant Professor, UC Department of Pediatrics

Science Blog

My Education

BA: St. Mary's College of Maryland, St. Mary's City, MD, 2000.

PhD: University of Virginia, Charlottesville, VA, 2007.

Post Doc: University of Massachusetts Medical School, Worcester, MA.

My Publications

Critical Role of Lipid Scramblase TMEM16F in Phosphatidylserine Exposure and Repair of Plasma Membrane after Pore Formation. Wu, N; Cernysiov, V; Davidson, D; Song, H; Tang, J; Luo, S; Lu, Y; Qian, J; Gyurova, IE; Waggoner, SN; et al. Cell Reports. 2020; 30:1129-1140.e5.

Circadian Rhythms in Immunity. Waggoner, SN. Current Allergy and Asthma Reports. 2020; 20.

Dynamic Changes in Natural Killer Cell Subset Frequencies in the Absence of Cytomegalovirus Infection. Gyurova, IE; Schlums, H; Sucharew, H; Ambroggio, L; Ochayon, DE; Win, HT; Bryceson, YT; Bernsteins, DI; Waggoner, SN. Frontiers in Immunology. 2019; 10.

Characterization of Transcriptional Regulatory Networks that Promote and Restrict Identities and Functions of Intestinal Innate Lymphoid Cells. Pokrovskii, M; Hall, JA; Ochayon, DE; Yi, R; Chaimowitz, NS; Seelamneni, H; Carriero, N; Watters, A; Waggoner, SN; Littman, DR; et al. Immunity. 2019; 51:185-197.e6.

Genetic, Inflammatory, and Epithelial Cell Differentiation Factors Control Expression of Human Calpain-14. Miller, DE; Forney, C; Rochman, M; Cranert, S; Habel, J; Rymer, J; Lynch, A; Schroeder, C; Lee, J; Sauder, A; et al. G3-Genes Genomes Genetics. 2019; 9:g3.200901.2018-g3.200901.2018.

Therapeutic Targeting of Follicular Helper T Cells with Chimeric Antigen Receptor-Expressing Natural Killer Cells. Reighard, SD; Cranert, SA; Rangel, KM; Ali, A; Cruz-Lynch, AT D L; Tuazon, JA; Kottyan, LC; Smith, DF; Brunner, HI; Waggoner, S. 2019.

Mutually assured destruction: the cold war between viruses and natural killer cells. Ali, A; Gyurova, IE; Waggoner, SN. Current Opinion in Virology. 2019; 34:130-139.

Affinity Maturation Is Impaired by Natural Killer Cell Suppression of Germinal Centers. Rydyznski, CE; Cranert, SA; Zhou, JQ; Xu, H; Kleinstein, SH; Singh, H; Waggoner, SN. Cell Reports. 2018; 24:3367-3373.e4.

Weak vaccinia virus-induced NK cell regulation of CD4 T cells is associated with reduced NK cell differentiation and cytolytic activity. Hatfield, SD; Daniels, KA; O'Donnell, CL; Waggoner, SN; Welsh, RM. Virology. 2018; 519:131-144.

Deletion of Slam locus in mice reveals inhibitory role of SLAM family in NK cell responses regulated by cytokines and LFA-1. Guo, H; Cranert, SA; Lu, Y; Zhong, M; Zhang, S; Chen, J; Li, R; Mahl, SE; Wu, N; Davidson, D; et al. The Journal of Experimental Medicine. 2016; 213:2187-2207.