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Melendez, J., Matthew Grogg, M., Zheng, Y.Signaling role of Cdc42 in regulating mammalian physiology. J Biol Chem. 286: 2375-2381, doi:10.1074/jbc.R110.200329. PMID: 21115489. 2011.
Liu M, Lang N, Chen X, Tang Q, Liu S, Huang J, Zheng Y, Bi F.MiR-185 Targets RhoA and Cdc42 Expression and Inhibits the Proliferation Potential of Human Colorectal Cells. Cancer Letter;301(2):151-60. PMID:21186079. 2011.
Akunuru, S., Palumbo, J., Zhan, Z., J.,Zheng, Y.Rac1 targeting suppresses human non-small cell lung adenocarcinoma cancer stem cell activity. PLoS One 2011 Feb 9;6(2):e16951. PMID:21347385. doi:10.1371/journal.pone.0016951. 2011.
Wang X, Zhang F, Chen F, Liu D, Zheng Y, Zhang Y, Dong C, Su B. MEKK3 Regulates IFN-{gamma} Production in T Cells through the Rac1/2-Dependent MAPK Cascades. J Immunol. 186(10):5791-800. PMID: 21471448. 2011.
Liu, W., Feng, Y., Shang, X., and Zheng, Y. Rho GTPases in hematopoietic stem/progenitor cell migration. Methods Mol Biol. 750:307-319. 2011.
Chauhan, B. K., Lou, M., Zheng, Y., and Lang, R. (2011) Balanced Rac1 and RhoA activity regulates cell shape and invagination morphogenesis in epithelia. Proc Natl Acad Sci U S A. 2011 Oct 20. [Epub ahead of print] PMID:22021442.
Guo F, Zhang S, Tripathi P, Mattner J, Phelan J, Sproles A, Mo J, Wills-Karp M, Grimes HL, Hildeman D, Zheng, Y. Essential role of Cdc42 for positive selection and effector/memory T cell differentiation during T cell development. PLoS One 6(3):e18002. PMID:21455314. 2011.
Stengel, K., and Zheng, Y. Cdc42 in oncogenic transformation, invasion, and tumorigenesis. Cell Signaling 23(9):1415-23. PMID: 21515363. 2011.
Shang X, Cancelas JA, Li L, Guo F, Liu W, Johnson JF, Ficker A, Daria D, Geiger H, Ratner N, Zheng Y.R-Ras and Rac GTPase Crosstalk Controls Hematopoietic Progenitor Cell Migration, Homing and Mobilization. J. Biol. Chem. 286(27):24068-78. PMID:21572048. 2011.
Geh, E., Meng, Q., Mongan, M., Wang, J., Takatori, A., Chauhan, B., K., Zheng, Y., Puga, A., Lang, R.A., and Xia, Y.Mitogen-activated protein kinase kinase kinase 1 (MAP3K1) integrates developmental signals for eyelid closure. Proc. Natl. Acad. Sci. USA 108(42):17349-54. PMID: 21969564. 2011.
Melendez J, Stengel K, Zhou X, Chauhan BK, Debidda M, Andreassen P, Lang RA, Zheng Y. RhoA GTPase is dispensable for actomyosin regulation but is essential for mitosis in primary mouse embryonic fibroblasts. J Biol Chem 286(17):15132-7. PMID:21454503. 2011.
Arumugam, M., Ahrens, R., Osterfeld, H., Kottyan, L C., Shang, X., John A Maclennan, Nives Zimmermann, Zheng, Y.,Finkelman, F. D., and Hogan, S. P.Increased susceptibility of 129SvEvBrd mice to IgE-Mast cell mediated anaphylaxis. BMC Immunology 2011, 12:14doi:10.1186/1471-2172-12-14. 2011.
Sipes NS, Feng Y, Guo F, Lee HO, Chou FS, Cheng J, Mulloy J, Zheng Y.Cdc42 regulates extracellular matrix remodeling in three dimensions. J Biol Chem 286(42):36469-77. PMID:21880728. 2011.
Akbar H, Shang X, Perveen R, Berryman M, Funk K, Johnson JF, Tandon NN, Zheng Y. Gene targeting implicates Cdc42 GTPase in GPVI and non-GPVI mediated platelet filopodia formation, secretion and aggregation. PloS One 6: (7) e22117-26. PMID: 21789221. 2011.
Katayama, K., Melendez, J., Baumann, J., Leslie, J., Chauhan, B.K., Nemkul, N., Lang, R. A., Kuan, C.-Y., Zheng, Y., and Yoshida, Y. Loss of RhoA in neural progenitor cells causes the disruption of adherens junctions and hyperproliferation. Proc. Natl. Acad. Sci. USA 108(18):7607-12. PMID:21502507. 2011.
Liu M, Tang Q, Qiu M, Lang N, Li M, Zheng Y, Bi F. miR-21 Targets the Tumor Suppressor Gene RhoB and Regulates Proliferation, Invasion and Apoptosis in Colorectal Cancer Cells. FEBS Lett. 585(19):2998-3005. PMID:21872591. 2011.
Morrison, M. A., Morreale, R. J., Akunuru, S., Kofron, M., Zheng, Y., and Wells, S. I. Targeting the Human Papillomavirus E6 and E7 Oncogenes through Expression of the Bovine Papillomavirus Type 1 E2 Protein Stimulates Cellular Motility. J Virology 85(20):10487-98. PMID: 21835799. 2011.
Mizukawa, B., Wei, J., Shrestha, M., Wunderlich, M., Chou, F.S., Griesinger, A., Harris, C. E., Kumar, A. R., Zheng, Y., Williams, D. A., and Mulloy, J. C. Inhibition of Rac GTPase signaling and downstream pro-survival Bcl-2 proteins as combination targeted therapy in MLL-AF9 leukemia. Blood 2011 Sep 22. [Epub ahead of print] PMID: 21940819. 2011.
Qian L, Wythe JD, Liu J, Cartry J, Vogler G, Mohapatra B, Otway RT, Huang Y, King IN, Maillet M,Zheng Y, Crawley T, Taghli-Lamallem O, Semsarian C, Dunwoodie S, Winlaw D, Harvey RP, Fatkin D, Towbin JA, Molkentin JD, Srivastava D, Ocorr K, Bruneau BG, Bodmer R.Tinman/Nkx2-5 acts via miR-1 and upstream of Cdc42 to regulate heart function across species. J Cell Biol. 193(7):1181-96. 2011.
Xiang SY, Vanhoutte D, Del Re DP, Purcell NH, Ling H, Banerjee I, Bossuyt J, Lang RA, Zheng Y, Matkovich SJ, Miyamoto S, Molkentin JD, Dorn GW 2nd, Brown JH.RhoA protects the mouse heart against ischemia/reperfusion injury. J Clin Invest. 121(8):3269-76. PMID:21747165. 2011.
Maddala R, Chauhan BK, Walker C, Zheng Y, Robinson ML, Lang RA, Rao PV.Rac1 GTPase -deficient mouse lens exhibits defects in shape, suture formation, fiber cell migration and survival. Dev. Biol. [Epub ahead of print] PMID: 21945075. September 16, 2011.
Plageman, T., Chauhan, B., Jaudon, F., Lou, M., Shang, X., Debant, A., Zheng, Y., Lang, R.A. A Trio-RhoA-Shroom3 pathway is required for apical constriction and epithelial invagination. Development in press. 2011.
Bosco, E. E., Ni, W., Wang, L., Guo, F., Johnson, J. F., and Zheng, Y. Rac1 targeting suppresses p53-deficiency mediated lymphomagenesis. Blood 115: 3320 - 3328. 2010.
Bosco, E. E., Nakai, Y., Hennigan, R. F., Ratner, N., Zheng, Y. Nf2-deficient cells depend on Rac1-canonical Wnt signaling pathway to promote the loss of contact inhibition of proliferation. Oncogene 29(17):2540-9. PMID: 20154721. 2010.
Kalfa, T. A., Suvarnamala, P., Zhang, X., Johnson, J. F., Pan, D., Daria, D., Geiger, H., Cancelas, J. A., Williams, D. A., and Zheng, Y.Rac1 and Rac2 GTPases are necessary for early erythropoietic expansion in the bone marrow but not in the spleen. Haematologica 95, 27-35. 2010.
Zhou J, Zhu Y, Zhang G, Liu N, Sun L, Liu M, Qiu M, Luo D, Tang Q, Liao Z, Zheng Y, Bi F.A distinct role of RhoB in gastric cancer suppression. Int. J. Cancer 128(5):1057-68. doi: 10.1002/ijc.25445. PMID:20473933. 2010.
Mulloy, J. C.,, Cancelas, J. C., Filippi, M.-D., Kalfa, T. A., Guo, F., and Zheng, Y. Rho GTPases in hematopoiesis and hemopathies. Blood 115:936-47. 2010.
George A, Pushkaran S, Li L, An X,Zheng Y, Mohandas N, Joiner CH, Kalfa TA. Altered phosphorylation of cytoskeleton proteins in sickle red blood cells: The role of protein kinase C, Rac GTPases, and reactive oxygen species. Blood Cells Mol Dis. 45(1):41-5. PMID: 20231105. 2010.
Kanai, M., Crowe, M. S., Zheng, Y., Vande Woude, G. F., and Fukasawa, K. RhoA and RhoC Are Both Required for the ROCK II-dependent Promotion of Centrosome Duplication. Oncogene 29(45):6040-50. PMID: 20697357. 2010.
Ryan, M. A., Xing, E., Schleimer, D., Nattamai, K. J., Daria, D., Liu, W., Jansen, M., Ratner, N., Le Cras, T., Van Zant, G., Cancelas, J., Zheng, Y., and Geiger, H. Pharmacological inhibition of EGFR signaling enhances G-CSF induced hematopoietic stem cell mobilization efficiency. Nature Med. 16(10):1141-6. PMID: 20871610. 2010.
Ito Y, Teitelbaum SL, Zou W, Zheng Y, Johnson JF, Chappel J, Ross FP, Zhao H. Cdc42 regulates bone modeling and remodeling in mice by modulating RANKL/M-CSF signaling and osteoclast polarization. J Clin Invest. 120(6):1981-93. doi: 10.1172/JCI39650. PMID: 20501942. 2010.
Liu M, Lang N, Qiu M, Xu F, Li Q, Tang Q, Chen J, Chen X, Zhang S, Liu Z, Zhou J, Zhu Y, Deng Y, Zheng Y, Bi F. miR-137 Targets Cdc42 Expression, Induces Cell Cycle G1 Arrest, and Inhibits Invasion in Colorectal Cancer Cells. Int. J. Cancer 128(6):1269-79. doi: 10.1002/ijc.25452. PMID: 20473940 . 2010.
Guo F, Hildeman D, Tripathi P, Velu CS, Grimes HL, Zheng Y.Coordination of IL-7 receptor and T cell receptor signaling by Cdc42 in T cell homeostasis. Proc Natl Acad Sci U S A 107(43):18505-10. PMID: 20937872. 2010.
Chen, L., Melendez, J., Campbell, K., Kuan, C.-Y., and Zheng, Y. Rac1 deficiency in the forebrain results in neural progenitor reduction and microcephaly. Dev.Biol. 325(1):162-170. 2009.
Flevaris, P., Li, Z., Zhang, G., Zheng, Y., Liu, J., and Du, X. Two distinct roles of mitogen-activated protein kinases in platelets and a novel Rac1-MAPK-dependent integrin outside-in retractile signaling pathway. Blood 113(4):893-901. 2009.
Grogg, M., and Zheng, Y. Rho GTPase-activating proteins in cancer. In “Rho GTPases in cancer”, Springer Publisher, in press. 2009.
Zhang, S., Tang, Q., Deng, Y., Xue, Y., Liu, M., Liu, S., Xu, F., Shi, F., Zheng, Y., Bi, F. RhoA regulates G1/S progression of gastric cancer cells by modulation of multiple INK4 family tumor suppressors. Mol. Cancer Research 7(4):570-80. 2009.
Bosco, E., Mulloy, J., and Zheng, Y. Rac1 GTPase: a “Rack” of all trade. Cell. Mol. Life Sci. 66(3):370-4. 2009.
Marchioni, F., and Zheng, Y. Targeting Rho GTPases by peptidic structures. Current Pharmaceutical Design 15, 2481-2487. 2009.
Guo F, Velu CS, Grimes HL, and Zheng, Y.Rho GTPase Cdc42 is essential for B lymphocyte development and activation. Blood 114(14):2909-16. 2009.
Xu, C., Zhang, Y. H., Thangavel, M., Richardson, M. M., Liu, L., Zhou, B., Zheng, Y., Ostrom, R. S., and Zhang, X. A. CD82 endocytosis and cholesterol-dependent reorganization of tetraspanin webs and lipid rafts. FASEB J. 23(10):3273-88 PMID: 19497983. 2009.
Stengel, K. R., Chellapangal, T., Solomon, D. A., Angus, S. P., Zheng, Y., Knudsen, E. S. RB/p107/130 pocket proteins: Protein dynamics and interactions with target gene promoters. J. Biol. Chem. 284(29):19265-71. 2009.
Milsom, M. D., Lee, A. W., Zheng, Y., Cancelas, J. A. Fanca-/- hematopoietic stem cells demonstrate a mobilization defect which can be overcome by administration of the Rac inhibitor NSC23766. Haematologica 94(7):1011-5. 2009.
Szczur, K.,Zheng, Y., and Filippi, M.-D. The Rho GTPase Cdc42 regulates neutrophil polarity via microtubule driven CD11b integrin signaling. Blood 14(20):4527-37. 2009.
Xu, H., Eleswarapu S, Geiger H, Szczur K, Daria D, Zheng Y, Settleman J, Srour EF, Williams, D. A., and Filippi, M.-D. Loss of the Rho GTPase activating protein p190-B enhances hematopoietic stem cell engraftment potential. Blood 114(17):3557-66. 2009.
Maillet M, Lynch JM, Sanna B, York AJ, Zheng Y, Molkentin JD. Cdc42 is an antihypertrophic molecular switch in the mouse heart. J Clin Invest. 119(10):3079-88. doi: 10.1172/JCI37694. 2009.
Chauhan BK, Disanza A, Choi SY, Faber SC, Lou M, Beggs HE, Scita G, Zheng Y, Lang RA. Cdc42 and IRSp53-dependent contractile filipodia tether presumptive lens and retina to coordinate epithelial invagination. Development 136(21):3657-67. 2009.
Guo, F., Cancelas, J., Hilderman, D., Williams, D. A., and Zheng, Y. Rac GTPase isoforms, Rac1 and Rac2, play redundant and critical role in T-cell development. Blood 112(5):1767-75. 2008.
Wei, J., Fox, C., Wunderlich, M., Alvarez, S., Cigudosa, J. C., Wilhelm, J. E., Zheng, Y., Cancelas, J., Gu, Y., Jansen, M., DiMartino, J. F., and Mulloy. J. C. Microenvironment Determines Lineage Fate in a Human Model of MLL-AF9 Leukemia. Cancer Cell 13, 483-495. 2008.
Zhang, X., Shang, X., Guo, F., Murphy, K., Kirby, M., Kelly, P., Reeves, L., Smith, F. O., Williams, D. A., Zheng, Y.*, and Pang, Q.* Defective adhesion, migration and homing are associated with altered Cdc42 activity in cells from Fanconi anemia patients. Blood 112(5):1683-6. 2008. *co-senior authors.
Yang, L, Wang, L, Kalfa, T, Cancelas, JA, Shang, X, Pushkaran, S, Mo, J, Williams, DA, Zheng, Y. Cdc42 critically regulates the balance between myelopoiesis and erythropoiesis. Blood 110: 3853 - 3861. 2007.
Chen, L., Liao, G., Walclaw, R., Burns, K. A., Linquist, D., Campbell, K., Zheng, Y.*, and Kuan, C.-Y.* Rac1 controls the formation of midline commissures and the competency of tangential migration in ventral telencephalic neurons. J. Neuroscience 27(14):3884-93. 2007. *co-senior authors.
Akbar, H, Kim, J, Funk, K, Cancelas, JA, Shang, X, Chen, L, Johnson, JF, Williams, DA, Zheng Y. Genetic and pharmacological evidence that Rac1 GTPase is involved in regulation of platelet secretion and aggregation. J Thromb Haemost. 5(8):1747-1755. 2007.
Shang, X., Moon, S. Y., and Zheng, Y. p200 RhoGAP promotes cell proliferation by mediating cross-talk between Ras and Rho signaling pathways. J. Biol. Chem. 282: 8801-8811. 2007.
Yang, L., Wang, L., Cancelas, J., Geiger, H., Mo, J., and Zheng, Y. The Rho GTPase Cdc42 coordinates hematopoietic stem cell quiescence and niche interaction in the bone marrow. Proc. Natl. Acad. Sci. U.S.A. 104:5091-5096. 2007.
Wang, L., Yang, L., Debidda, M., Witte, D., and Zheng, Y. Cdc42 GTPase-activating protein deficiency promotes genomic instability and premature aging-like phenotypes. Proc. Natl. Acad. Sci. U.S.A. 104: 1248-1253. 2007.
Guo, D., Tan, Y., Wang, D., Madhusoodanan, K. S., Zheng, Y., Maack, T., Zhang, J. J., and Huang, X.-Y. A Rac-cGMP signaling pathway. Cell 128, 341-356. 2007.
Wang, L., and Zheng, Y. Cell type specific function of Rho GTPases revealed by gene targeting in mice. Trends Cell Biol. 17, 58-64. 2007.
Debidda, M., Williams, D. A., and Zheng, Y. Rac1 GTPase regulates cell genomic stability and senescence. J. Biol. Chem. 281: 38519 - 38528. 2006.
Yang, L., Wang, L., and Zheng, Y. Gene targeting of Cdc42 and Cdc42GAP affirms the critical involvement of Cdc42 in filopodia formation, directed migration, and proliferation in primary mouse embryonic fibroblasts. Mol. Biol. Cell 17: 4675-4685. 2006.
Kalfa, T. A., Pushkaran, S., Mohandas, N., Hartwig, J. H., Johnson, J. F., Joiner, C. H., Williams, D. A., and Zheng, Y. Rac GTPases regulate the morphology and deformability of the erythrocyte cytoskeleton. Blood 108(12), 3637-3645. 2006.
Chen, L., Liao, G., Yang, L., Campbell, K., Nakafuku, M., Kuan, C., and Zheng, Y. Cdc42 deficiency causes sonic hedgehog-independent holoprosencephaly. Proc. Natl. Acad. Sci. U.S.A. 103, 16520-16525. 2006.
Gu, Y., Siefring, J. E., Wang, L., Chae, H. D., Bailey, J. R., and Zheng, Y. Oncogenic Vav1 induces Rac-dependent apoptosis via inhibition of Bcl-2 family proteins and collaborates with p53 deficiency to promote hematopoetic progenitor cell proliferation. Oncogene 25, 3963-72. 2006.
Guo, F., Debidda, M., Yang, L., Williams, D. A., and Zheng, Y. Genetic deletion of Rac1 reveals its critical role in actin stress fiber formation and focal adhesion complex assembly. J. Biol. Chem. 281, 18652-9. 2006.
Wang, L., Yang, L., Fillipi, M., Williams, D.A. and Zheng, Y. Deletion of Cdc42GAP reveals a role of Cdc42 in erythropoiesis and hematopoietic stem/progenitor cell survival, migration and engraftment. Blood 107, 98-105. 2006.
Akbar, H., Cancelas, J., Williams, D. A., Zheng, J., and Zheng, Y. Rational design and applications of a Rac GTPase-specific small molecule inhibitor. Methods Enzymol. 406, 554-565. 2006.
Wang, L., Yang, L., Burns, K., Kuan, C.-Y., and Zheng, Y. Cdc42GAP regulates JNK-mediated apoptosis and cell number during mammalian perinatal growth. Proc. Natl. Acad. Sci. U.S.A. 102: 13484-13489. 2005.
Cancelas, J. A., Lee, A. W., Prabhakar, R., Stringer, K., Zheng, Y., and Williams, D. A. Rac1 and Rac2 GTPases distinctly regulate hematopoietic stem cell localization and are novel targets for stem cell mobilization. Nature Medicine 11(8):886-91. 2005.
Zhang, B., Zhang, Y., Shacter, E., and Zheng, Y. Mechanism of the guanine nucleotide exchange reaction of Ras GTPase – Evidence for a GTP/GDP displacement model. Biochemistry 44, 2566-2576. 2005.
Debidda, M., Wang, L., Zang, H., Poli, V., and Zheng, Y. A role of STAT3 in Rho GTPase regulated cell migration and proliferation. J. Biol. Chem. 280: 17275-17285. 2005.
Guo, F., and Zheng, Y. Involvement of Rho family GTPases in p19Arf or p53 mediated proliferation of primary mouse embryonic fibroblasts. Mol. Cell Biol. 24, 1426-1428. 2004.
Debreceni, B., Gao, Y., Guo, F., Zhu, K., Jia, B., and Zheng, Y. Mechanism of guanine nucleotide exchange and Rac-mediated signaling revealed by a dominant negative Trio mutant. J. Biol. Chem. 279, 2777-2786. 2004.
Cook-Mills JM, Johnson JD, Deem TL, Ochi A, Wang L, Zheng Y. Calcium mobilization and Rac1 activation are required for VCAM-1 (vascular cell adhesion molecule-1) stimulation of NADPH oxidase activity. Biochem. J. 378, 539-47. 2004.
Barac, A., Basile, J., Vázquez-Prado, J., Gao, Y., Zheng, Y., and Gutkind, J. S. Direct interaction of PAK4 with PDZ-RhoGEF, a G protein-linked Rho guanine exchange factor. J. Biol. Chem. 279, 6182-6189. 2004.
Gao, Y., Dickerson, J. B., Guo, F., Zheng, J., and Zheng, Y. Rational design and characterization of a Rac GTPase-specific small molecule inhibitor. Proc. Natl. Acad. Sci. U. S. A. 101, 7618-7623. 2004.
Skowronek, K. R., Guo, F., Zheng, Y., and Nassar, N. The C-terminal basic tail of RhoG assists the guanine nucleotide exchange factor Trio in binding to phospholipids. J. Biol.Chem. 279: 37895-37907. 2004.
Filippi, M.-D., Harris, C. E., Meller, J., Gu, Y., Zheng, Y., and Williams, D. A. Localization of Rac2 specifies superoxide generation, actin polarity and chemotaxis in neutrophils. Nature Immunology 5, 744-751. 2004.
Wang, L., Zhu, K., and Zheng, Y. Oncogenic Dbl, Cdc42, and p21-activated kinase form a functional signaling complex through the minimum interactive domains. Biochemistry 43, 14584-93. 2004.
Moon, S. Y. and Zheng, Y. Rho GTPase-activating proteins in cell regulation. Trends Cell Biol. 13, 14-23. 2003.
Moon, S., Zang, H., and Zheng, Y. Characterization of a brain specific Rho GTPase activating protein, p200RhoGAP. J. Biol. Chem. 278, 4151-4159. 2003.
Sigal, N., Gorzalczany, Y., Sarfstein, R., Weinbaum, C., Zheng, Y., and Pick, E. The Rac guanine nucleotide exchange factor Trio activates the phagocyte NADPH oxidase independently of GTP. J. Biol. Chem. 278, 4854-4861. 2003.
Guo, F., Gao, Y., Wang, L., and Zheng, Y. p19Arf-p53 tumor suppressor pathway regulates cell motility by suppression of PI3 kinase and Rac activities. J. Biol. Chem. 278, 14414-14419. 2003.
Wang, L., Yang, L., Luo, Y., and Zheng, Y. A novel strategy for downregulating individual Rho GTPase activities in tumor cells. J. Biol. Chem. 278, 44617-44625. 2003.
