A photo of Yi Zheng.

Yi Zheng, PhD


  • Director, Experimental Hematology and Cancer Biology
  • Institute Co- Executive Director, Cancer and Blood Diseases Institute
  • Marjory Johnson Endowed Chair of Drug Discovery
  • Professor, UC Department of Pediatrics

About

Publications

Selected

Adaptive responses to mTOR gene targeting in hematopoietic stem cells reveal a proliferative mechanism evasive to mTOR inhibition. Fan, C; Zhao, C; Zhang, F; Kesarwani, M; Tu, Z; Cai, X; Davis, AK; Xu, L; Hochstetler, CL; Chen, X; et al. Proceedings of the National Academy of Sciences of the United States of America. 2021; 118.

Selected

Yap1-Scribble polarization is required for hematopoietic stem cell division and fate. Althoff, MJ; Nayak, RC; Hegde, S; Wellendorf, AM; Bohan, B; Filippi, MD; Xin, M; Richard Lu, Q; Geiger, H; Zheng, Y; et al. Blood. 2020; 136:1824-1836.

Selected

Inhibition of Cdc42 activity extends lifespan and decreases circulating inflammatory cytokines in aged female C57BL/6 mice. Florian, MC; Leins, H; Gobs, M; Han, Y; Marka, G; Soller, K; Vollmer, A; Sakk, V; Nattamai, KJ; Rayes, A; et al. Aging Cell. 2020; 19.

Selected

Adaptive response to inflammation contributes to sustained myelopoiesis and confers a competitive advantage in myelodysplastic syndrome HSCs. Muto, T; Walker, CS; Choi, K; Hueneman, K; Smith, MA; Gul, Z; Garcia-Manero, G; Ma, A; Zheng, Y; Starczynowski, DT. Nature Immunology. 2020; 21:535-545.

Selected

ARHGEF12 regulates erythropoiesis and is involved in erythroid regeneration after chemotherapy in acute lymphoblastic leukemia patients. Xie, Y; Gao, L; Xu, C; Chu, L; Gao, L; Wu, R; Liu, Y; Liu, T; Sun, X; Ren, R; et al. Haematologica. 2020; 105:925-936.

Selected

Latexin regulation by HMGB2 is required for hematopoietic stem cell maintenance. Zhang, C; Fondufe-Mittendorf, YN; Wang, C; Chen, J; Cheng, Q; Zhou, D; Zheng, Y; Geiger, H; Liang, Y. Haematologica. 2020; 105:573-584.

Selected

Rho GTPase-Activating Proteins in Cancer. Grogg, MW; Zheng, Y. The Rho GTPases in Cancer. 2010.

Role of Rho GTPases in stem cell regulation. Zhang, Z; Liu, M; Zheng, Y. Biochemical Society Transactions. 2021; 49:2941-2955.

Modulation of Both Intrinsic and Extrinsic Factors Additively Promotes Rewiring of Corticospinal Circuits after Spinal Cord Injury. Nakamura, Y; Ueno, M; Niehaus, JK; Lang, RA; Zheng, Y; Yoshida, Y. Journal of Neuroscience. 2021; 41:10247-10260.

Cdc42-Borg4-Septin7 axis regulates HSC polarity and function. Kandi, R; Senger, K; Grigoryan, A; Soller, K; Sakk, V; Schuster, T; Eiwen, K; Menon, MB; Gaestel, M; Zheng, Y; et al. EMBO Reports. 2021; 22.