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Director, Experimental Hematology and Cancer Biology
Institute Co- Executive Director, Cancer and Blood Diseases Institute
Marjory Johnson Endowed Chair of Drug Discovery
Professor, UC Department of Pediatrics
Using transgenic and gene targeted mouse models to study the physiological and pathological roles of Rho GTPases and their regulators in hematopoiesis, neurogenesis, lung cancer development and small intestinal stem cell regulations mechanism based, rational design of small molecule inhibitors targeting Rho GTPase signaling modules and pathologic functions in cancer and blood diseases; mouse model studies of mTor signaling function in hematopoietic stem cells and small intestinal stem cells.
Experimental Hematology and Cancer Biology, Cancer and Blood Diseases
Yi Zheng, PhD12/21/2020
Yi Zheng, PhD, Jose A. Cancelas Perez, MD, PhD7/1/2019
Yi Zheng, PhD6/30/2019
BS: Tsinghua University, Beijing, China, 1986.
MS: Cornell University, Ithaca, NY, 1988.
PhD: Cornell University, Ithaca, NY, 1991.
Postdoctoral Fellow: Cornell University, Ithaca, NY, 1995.
Adaptive responses to mTOR gene targeting in hematopoietic stem cells reveal a proliferative mechanism evasive to mTOR inhibition.
Fan, C; Zhao, C; Zhang, F; Kesarwani, M; Tu, Z; Cai, X; Davis, AK; Xu, L; Hochstetler, CL; Chen, X; et al.
Proceedings of the National Academy of Sciences of the United States of America.
Yap1-Scribble polarization is required for hematopoietic stem cell division and fate.
Althoff, MJ; Nayak, RC; Hegde, S; Wellendorf, AM; Bohan, B; Filippi, MD; Xin, M; Richard Lu, Q; Geiger, H; Zheng, Y; et al.
Inhibition of Cdc42 activity extends lifespan and decreases circulating inflammatory cytokines in aged female C57BL/6 mice.
Florian, MC; Leins, H; Gobs, M; Han, Y; Marka, G; Soller, K; Vollmer, A; Sakk, V; Nattamai, KJ; Rayes, A; et al.
Adaptive response to inflammation contributes to sustained myelopoiesis and confers a competitive advantage in myelodysplastic syndrome HSCs.
Muto, T; Walker, CS; Choi, K; Hueneman, K; Smith, MA; Gul, Z; Garcia-Manero, G; Ma, A; Zheng, Y; Starczynowski, DT.
ARHGEF12 regulates erythropoiesis and is involved in erythroid regeneration after chemotherapy in acute lymphoblastic leukemia patients.
Xie, Y; Gao, L; Xu, C; Chu, L; Gao, L; Wu, R; Liu, Y; Liu, T; Sun, X; Ren, R; et al.
Latexin regulation by HMGB2 is required for hematopoietic stem cell maintenance.
Zhang, C; Fondufe-Mittendorf, YN; Wang, C; Chen, J; Cheng, Q; Zhou, D; Zheng, Y; Geiger, H; Liang, Y.
Rho GTPase-Activating Proteins in Cancer.
Grogg, MW; Zheng, Y.
The Rho GTPases in Cancer.
Protocol for structural and biochemical analyses of RhoA GTPase.
Lin, Y; Watanabe-Chailland, M; Zheng, Y.
Structure of an inactive conformation of GTP-bound RhoA GTPase.
Lin, Y; Lu, S; Zhang, J; Zheng, Y.
Structure with Folding & design.
Suppression of elevated Cdc42 activity promotes the regenerative potential of aged intestinal stem cells.
Nalapareddy, K; Hassan, A; Sampson, LL; Zheng, Y; Geiger, H.
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