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BS: Tsinghua University, Beijing, China, 1986.
MS: Cornell University, Ithaca, NY, 1988.
PhD: Cornell University, Ithaca, NY, 1991.
Postdoctoral Fellow: Cornell University, Ithaca, NY, 1995.
Using transgenic and gene targeted mouse models to study the physiological and pathological roles of Rho GTPases and their regulators in hematopoiesis, neurogenesis, lung cancer development and small intestinal stem cell regulations mechanism based, rational design of small molecule inhibitors targeting Rho GTPase signaling modules and pathologic functions in cancer and blood diseases; mouse model studies of mTor signaling function in hematopoietic stem cells and small intestinal stem cells.
Experimental Hematology and Cancer Biology, Cancer and Blood Diseases
Adaptive responses to mTOR gene targeting in hematopoietic stem cells reveal a proliferative mechanism evasive to mTOR inhibition. Fan, C; Zhao, C; Zhang, F; Kesarwani, M; Tu, Z; Cai, X; Davis, AK; Xu, L; Hochstetler, CL; Chen, X; et al. Proceedings of the National Academy of Sciences of the United States of America. 2021; 118.
Yap1-Scribble polarization is required for hematopoietic stem cell division and fate. Althoff, MJ; Nayak, RC; Hegde, S; Wellendorf, AM; Bohan, B; Filippi, MD; Xin, M; Richard Lu, Q; Geiger, H; Zheng, Y; et al. Blood. 2020; 136:1824-1836.
Inhibition of Cdc42 activity extends lifespan and decreases circulating inflammatory cytokines in aged female C57BL/6 mice. Florian, MC; Leins, H; Gobs, M; Han, Y; Marka, G; Soller, K; Vollmer, A; Sakk, V; Nattamai, KJ; Rayes, A; et al. Aging Cell. 2020; 19.
Adaptive response to inflammation contributes to sustained myelopoiesis and confers a competitive advantage in myelodysplastic syndrome HSCs. Muto, T; Walker, CS; Choi, K; Hueneman, K; Smith, MA; Gul, Z; Garcia-Manero, G; Ma, A; Zheng, Y; Starczynowski, DT. Nature Immunology. 2020; 21:535-545.
ARHGEF12 regulates erythropoiesis and is involved in erythroid regeneration after chemotherapy in acute lymphoblastic leukemia patients. Xie, Y; Gao, L; Xu, C; Chu, L; Gao, L; Wu, R; Liu, Y; Liu, T; Sun, X; Ren, R; et al. Haematologica. 2020; 105:925-936.
Latexin regulation by HMGB2 is required for hematopoietic stem cell maintenance. Zhang, C; Fondufe-Mittendorf, YN; Wang, C; Chen, J; Cheng, Q; Zhou, D; Zheng, Y; Geiger, H; Liang, Y. Haematologica. 2020; 105:573-584.
Rho GTPase-Activating Proteins in Cancer. Grogg, MW; Zheng, Y. The Rho GTPases in Cancer. 2010.
Role of Rho GTPases in stem cell regulation. Zhang, Z; Liu, M; Zheng, Y. Biochemical Society Transactions. 2021; 49:2941-2955.
Modulation of Both Intrinsic and Extrinsic Factors Additively Promotes Rewiring of Corticospinal Circuits after Spinal Cord Injury. Nakamura, Y; Ueno, M; Niehaus, JK; Lang, RA; Zheng, Y; Yoshida, Y. Journal of Neuroscience. 2021; 41:10247-10260.
Cdc42-Borg4-Septin7 axis regulates HSC polarity and function. Kandi, R; Senger, K; Grigoryan, A; Soller, K; Sakk, V; Schuster, T; Eiwen, K; Menon, MB; Gaestel, M; Zheng, Y; et al. EMBO Reports. 2021; 22.
Yi Zheng, PhD12/21/2020
Yi Zheng, PhD, Jose A. Cancelas Perez, MD, PhD7/1/2019
Yi Zheng, PhD6/30/2019