A photo of Yi Zheng.

Yi Zheng, PhD

  • Director, Experimental Hematology and Cancer Biology
  • Institute Co- Executive Director, Cancer and Blood Diseases Institute
  • Marjory Johnson Endowed Chair of Drug Discovery
  • Professor, UC Department of Pediatrics

About

BS: Tsinghua University, Beijing, China, 1986.

MS: Cornell University, Ithaca, NY, 1988.

PhD: Cornell University, Ithaca, NY, 1991.

Postdoctoral Fellow: Cornell University, Ithaca, NY, 1995.

Interests

Using transgenic and gene targeted mouse models to study the physiological and pathological roles of Rho GTPases and their regulators in hematopoiesis, neurogenesis, lung cancer development and small intestinal stem cell regulations mechanism based, rational design of small molecule inhibitors targeting Rho GTPase signaling modules and pathologic functions in cancer and blood diseases; mouse model studies of mTor signaling function in hematopoietic stem cells and small intestinal stem cells.

Research Areas

Experimental Hematology and Cancer Biology, Cancer and Blood Diseases

Publications

Selected

Adaptive responses to mTOR gene targeting in hematopoietic stem cells reveal a proliferative mechanism evasive to mTOR inhibition. Fan, C; Zhao, C; Zhang, F; Kesarwani, M; Tu, Z; Cai, X; Davis, AK; Xu, L; Hochstetler, CL; Chen, X; et al. Proceedings of the National Academy of Sciences of the United States of America. 2021; 118.

Selected

Yap1-Scribble polarization is required for hematopoietic stem cell division and fate. Althoff, MJ; Nayak, RC; Hegde, S; Wellendorf, AM; Bohan, B; Filippi, MD; Xin, M; Richard Lu, Q; Geiger, H; Zheng, Y; et al. Blood. 2020; 136:1824-1836.

Selected

Inhibition of Cdc42 activity extends lifespan and decreases circulating inflammatory cytokines in aged female C57BL/6 mice. Florian, MC; Leins, H; Gobs, M; Han, Y; Marka, G; Soller, K; Vollmer, A; Sakk, V; Nattamai, KJ; Rayes, A; et al. Aging Cell. 2020; 19.

Selected

Adaptive response to inflammation contributes to sustained myelopoiesis and confers a competitive advantage in myelodysplastic syndrome HSCs. Muto, T; Walker, CS; Choi, K; Hueneman, K; Smith, MA; Gul, Z; Garcia-Manero, G; Ma, A; Zheng, Y; Starczynowski, DT. Nature Immunology. 2020; 21:535-545.

Selected

ARHGEF12 regulates erythropoiesis and is involved in erythroid regeneration after chemotherapy in acute lymphoblastic leukemia patients. Xie, Y; Gao, L; Xu, C; Chu, L; Gao, L; Wu, R; Liu, Y; Liu, T; Sun, X; Ren, R; et al. Haematologica. 2020; 105:925-936.

Selected

Latexin regulation by HMGB2 is required for hematopoietic stem cell maintenance. Zhang, C; Fondufe-Mittendorf, YN; Wang, C; Chen, J; Cheng, Q; Zhou, D; Zheng, Y; Geiger, H; Liang, Y. Haematologica. 2020; 105:573-584.

Selected

Rho GTPase-Activating Proteins in Cancer. Grogg, MW; Zheng, Y. The Rho GTPases in Cancer. 2010.

Angiopoietin-2-induced lymphatic endothelial cell migration drives lymphangiogenesis via the β1 integrin-RhoA-formin axis. Akwii, RG; Sajib, MS; Zahra, FT; Tullar, P; Zabet-Moghaddam, M; Zheng, Y; Silvio Gutkind, J; Doci, CL; Mikelis, CM. Angiogenesis. 2022; 25:373-396.

Autism-associated chromatin remodeler CHD8 regulates erythroblast cytokinesis and fine-tunes the balance of Rho GTPase signaling. Tu, Z; Fan, C; Davis, AK; Hu, M; Wang, C; Dandamudi, A; Seu, KG; Kalfa, TA; Lu, QR; Zheng, Y. Cell Reports. 2022; 40.

Role of ATP-dependent chromatin remodelers in hematopoietic stem and progenitor cell maintenance. Tu, Z; Zheng, Y. Current Opinion in Hematology. 2022; 29:174-180.