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 | Detection of E-cadherin by immunofluroescent staining shows epithelial cells & branching in early lung morphogenesis. (Picture courtesy of the Shannon laboratory.) |
Vrushank Davé, PhD: Transcriptional/signal networks in lung development and cancer
Vladimir Kalinichenko, MD, PhD: Fox proteins in lung development and carcinogenesis
Alan Kenny, MD, PhD: Molecular mechanisms early respiratory and gut development
Anne-Karina Perl, PhD: Lung repair processes and progenitor cells in lung development
John Shannon, PhD: Lung morphogenesis and differentiation, and FGFs
Susan Wert, PhD: Histopathology of abnormal lung development, injury / repair and human surfactant dysfunctions / mutations.
Jeffrey Whitsett, MD: Lung transcriptional control, epithelial patterning and differentiation
Yan Xu, PhD: Bioinformatics, systems biology of lung development and disease
 | Immunostaining for pro-surfactant protein C (black) identifies type II epithelial cells in the distal saccules of developing lung of a transgenic mouse at E17.0. |
Vrushank Davé, PhD: Transcriptional/signal networks in lung development and cancer
Stephan Glasser, PhD: SP-C in innate defense, interstitial lung disease and injury
Machiko Ikegami, MD, PhD: Lung development and C/EBPα
Vladimir Kalinichenko, MD, PhD: Fox proteins in lung development and carcinogenesis
Thomas Korfhagen, MD, PhD: Surfactant proteins, lung infection, inflammation, and injury/repair
Anne-Karina Perl, PhD: Lung repair processes and progenitor cells in lung development
John Shannon, PhD: Lung morphogenesis and differentiation, and FGFs
Susan Wert, PhD: Histopathology of abnormal lung development, injury / repair and human surfactant dysfunctions / mutations.
Jeffrey Whitsett, MD: Lung transcriptional control, epithelial patterning and differentiation
Yan Xu, PhD: Bioinformatics, systems biology of lung development and disease
 | Vascular morphogenesis in the developing lung is regulated by a complex system of epithelial-to-mesenchymal signaling mechanisms. Picture shows X-gal staining of lungs form Tie2-Lac Z mice at E12, which detects the endothelial plexus, a primitive vascular network that is forming alongside the developing airways. (Picture courtesy of Dr. Bridges in the Shannon laboratory.) |
James Greenberg, MD: Lung vascular, lymphatic, airway development and role of VEGF
Vladimir Kalinichenko, MD, PhD: Fox proteins in lung development and carcinogenesis
Timothy Le Cras, PhD: Lung development, pathogenesis of lung remodeling
John Shannon, PhD: Lung morphogenesis and differentiation, and FGFs
Jeffrey Whitsett, MD: Lung transcriptional control, epithelial patterning and differentiation
 | Arteriogram shows complex system of branches that develops in the lung to supply blood for oxygenation to the distal airspaces (alveoli). (Picture courtesy of the Le Cras laboratory.) |
James Greenberg, MD: Lung vascular, lymphatic, airway development and role of VEGF
Vladimir Kalinichenko, MD, PhD: Fox proteins in lung development and carcinogenesis
Timothy Le Cras, PhD: Lung development, pathogenesis of lung remodeling
Jeffrey Whitsett, MD: Lung transcriptional control, epithelial patterning and differentiation
 | Picture shows elastin fibers (black) in the walls of alveoli and at the tips of secondary septae in the lung. The correct deposition of elastin fibers is critical for alveologenesis and alveolar structure. Alveoli are the functional site of gas exchange in the lung and form the large surface area of the lung needed for gas exchange. (Picture courtesy of the Le Cras laboratory.) |
Timothy Le Cras, PhD: Lung development, pathogenesis of lung remodeling
Anne-Karina Perl, PhD: Lung repair processes and progenitor cells in lung development
John Shannon, PhD: Lung morphogenesis and differentiation, and FGFs
Susan Wert, PhD: Histopathology of abnormal lung development, injury / repair and human surfactant dysfunctions / mutations.
Jeffrey Whitsett, MD: Lung transcriptional control, epithelial patterning and differentiation
 | Electron micrograph shows that surfactant in the airspace is present in multiple forms including lamellar body, tubular myelin and small lipid vesicles. (Picture courtesy of the Ikegami laboratory.
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Stephan Glasser, PhD: SP-C in innate defense, interstitial lung disease and injury
Machiko Ikegami, MD, PhD: Surfactant metabolism and function
Paul Kingma, MD, PhD: SP-D in neonatal sepsis, RDS, innate immune system, neonatal infection
Thomas Korfhagen, MD, PhD: Surfactant proteins, lung infection, inflammation, and injury/repair
Ward Rice, MD, PhD: Molecular and cellular mechanisms regulating surfactant processing
John Shannon, PhD: Lung morphogenesis and differentiation, and FGFs
Timothy Weaver, PhD: Cytoprotective pathways, epithelium adaptation to stress, surfactant
Susan Wert, PhD: Histopathology of abnormal lung development, injury / repair and human surfactant dysfunctions / mutations.
Jeffrey Whitsett, MD: Lung transcriptional control, epithelial patterning and differentiation
Yan Xu, PhD: Bioinformatics, systems biology of lung development and disease
 | Double immunofluorescent staining shows a transcription factor (pink) in the nucleus of endothelial cells (green) of a primitive developing vessel in the fetal mouse lung E13.0. Nuclei were labeled with DAPI (blue) and the developing epithelium is on the right of the picture. (Picture courtesy of the Le Cras and Whitsett laboratories.) |
Vrushank Davé, PhD: Transcriptional/signal networks in lung development and cancer
Stephan Glasser, PhD: SP-C in innate defense, interstitial lung disease and injury
Machiko Ikegami, MD, PhD: Transcriptional control of surfactant maturation
Vladimir Kalinichenko, MD, PhD: Fox proteins in lung development and carcinogenesis
Anne-Karina Perl, PhD: Lung repair processes and progenitor cells in lung development
John Shannon, PhD: Lung morphogenesis and differentiation, and FGFs
Susan Wert, PhD: Histopathology of abnormal lung development, injury / repair and human surfactant dysfunctions / mutations.
Jeffrey Whitsett, MD: Lung transcriptional control, epithelial patterning and differentiation
Kathryn Wikenheiser-Brokamp, MD, PhD: Epithelial cell growth regulation, pathways in lung cancer
Yan Xu, PhD: Bioinformatics, systems biology of lung development and disease
 | Fluorescent staining detects cells, which have originated from a common progenitor source, populating the tracheal rings. (Picture courtesy of the Perl and Whitsett laboratories.) |
Timothy Le Cras, PhD: Lung development, pathogenesis of lung remodeling
Anne-Karina Perl, PhD: Lung repair processes and progenitor cells in lung development
John Shannon, PhD: Lung morphogenesis and differentiation, and FGFs
Susan Wert, PhD: Histopathology of abnormal lung development, injury / repair and human surfactant dysfunctions / mutations.
Jeffrey Whitsett, MD: Lung transcriptional control, epithelial patterning and differentiation
Kathryn Wikenheiser-Brokamp, MD, PhD: Epithelial cell growth regulation, pathways in lung cancer
Yan Xu, PhD: Bioinformatics, systems biology of lung development and disease
