Marc E. Rothenberg, MD, PhD
Title
Director Allergy and Immunology
Appointment
Professor of Pediatrics, University of Cincinnati College of Medicine
Email
marc.rothenberg@cchmc.org
Phone
513-636-7210
Fax
513-636-3310
Bio
Marc E. Rothenberg, MD, PhD, is the Director of the Division of Allergy and Immunology at Cincinnati Children's Hospital Medical Center, and a tenured Professor of Pediatrics at Cincinnati Children’s and the University of Cincinnati College of Medicine. He graduated summa cum laude with Highest Honors in Chemistry and Biochemistry from Brandeis University. He then matriculated at Harvard Medical School in the combined MD / PhD program. His PhD under the mentorship of Dr. Frank Austen included seminal studies on eosinophil hematopoiesis, as he developed the first culture system for human eosinophils. After completing a two-year residency in pediatrics at Children’s Hospital in Boston, Dr. Rothenberg did a combined fellowship in allergy / immunology and hematology at Children’s Hospital in Boston. During this fellowship program, Dr. Rothenberg did post-doctorate training in the genetics laboratory of Dr. Philip Leder at Harvard Medical School, where he cloned the eotaxin chemokine. After being on faculty of Harvard Medical School for one year, he came to the University of Cincinnati and Cincinnati Children's, one of the largest pediatric medical and research centers in the United States. He is actively involved in managing a research program focused on understanding the molecular mechanisms of allergic disorders. At Cincinnati Children’s, he has helped build a top program in pediatric research, and his division is a leader in pediatric allergy and immunology. In addition, he sees patients suffering from allergic and immunological diseases from around the world as part of the Cincinnati Center for Eosinophilic Disorders that he directs.
Dr. Rothenberg’s awards include the Pharmacia Allergy Research Foundation Award for the best young investigator in the allergy field; the Young Investigator Award and the Scholar in Allergy Award from the American Academy of Allergy, Asthma, and Immunology; the Ohio Governor’s Recognition Award; and the 2007 E Mead Johnson Award from the Society of Pediatric Research. He is an elected member of the American Society of Clinical Investigation, Society for Pediatric Research, and a Diplomate of the American Academy of Allergy, Asthma and Immunology. Among his extensive publications of over 150 articles on molecular mechanisms of allergic responses, Dr. Rothenberg edited a book entitled, “Chemokines in Allergic Disease”. He has served on various review panels for journals and grant agencies including the National Institutes of Health, Burroughs Trust, and the Medical Research Council of the UK. He is a current member of the Advisory Council of the NIAID. His research has been supported by numerous sources including the Human Frontier Science Program Organization, the Burroughs Wellcome Fund and the National Institutes of Health.
[Visit the Rothenberg Lab website]
Credentials
MD, PhD: Harvard Medical School, Cambridge, Mass., 1990.
Residency: Pediatrics, Children's Hospital, Boston, Mass., 1991-1992.
Fellowship: Immunology / Allergy, Children's Hospital, Boston, Mass., 1992-1994; Hematology / Oncology, Children's Hospital and Dana Farber Cancer Institute, Boston, Mass., 1992-1995.
Certification: National Board of Medical Examiners, 1991; Board of Registration in Medicine, MA, 1992; American Board of Pediatrics, 1995, 2001; Ohio State Medical Board, 1997; American Board of Allergy and Immunology, 1997; American Board of Pediatrics recertification, 2000.
Position History
Academic Appointments
- 1990-1991 Clinical Fellow in Pediatrics, Harvard Medical School
- 1992-1995 Research Fellow in Pediatrics, Harvard Medical School
- 1995-1996 Instructor of Pediatrics, Harvard Medical School
- 1996-1999 Assistant Professor of Pediatrics, University of Cincinnati College of Medicine
- 1996- Member, Graduate Program Molecular and Developmental Biology, University of Cincinnati College of Medicine
- 1998- Member, Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine
- 1998- Member, Department of Cell Biology, Neurobiology and Anatomy, University of Cincinnati College of Medicine
- 1999-2000 Associate Professor of Pediatrics, University of Cincinnati College of Medicine
- 2000-2002 Associate Professor of Pediatrics (tenured), University of Cincinnati College of Medicine
- 2001- Endowed Chair, Allergy and Immunology, Cincinnati Children's Hospital Research Foundation
- 2002- Professor of Pediatrics (tenured), University of Cincinnati College of Medicine
- 2002- Affiliate Faculty, Center for Epidemiology and Biostatistics, Department of Pediatrics, Cincinnati Children's Hospital Medical Center
- 2004- Member, Graduate Program of Immunobiology, University of Cincinnati College of Medicine
Clinical Appointments
- 1990-1991 Intern in Pediatrics, Children's Hospital, Boston, Ma.
- 1991-1992 Resident in Pediatrics, Children's Hospital, Boston, Ma.
- 1992-1994 Immunology/Allergy Fellow, Children's Hospital, Boston,
- 1992-1995 Hematology/Oncology Fellow, Children's Hospital and Dana Farber Cancer Institute, Boston, Ma.
- 1995-1996 Senior Staff Physician, Children's Hospital, Boston, Ma.
- 1996- Staff Physician, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
- 1999-2001 Section Chief, Section of Allergy and Clinical Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
- 2001- Director, Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
- 2005- Director, Cincinnati Center for Eosinophilic Disorders (CCED)
Awards and Honors
- Eastman Kodak Science and Engineering Regional Award, 1976
- National Honor Society, George W. Hewlett High School, 1979
- Phi beta kappa, Brandeis University, 1982
- Melvin N. Snyder Chemistry Award, Brandeis University, 1983
- Summa cum laude with highest honors in biochemistry and chemistry, Brandeis University, 1983
- Medical Scientist Training Program Award, Harvard Medical School, 1985
- Physician Scientist Training Program Award, Harvard Medical School, 1985
- Young Investigator Award, American Academy of Allergy and Immunology, 1988
- Scholar in Allergy Award, American Academy of Allergy and Immunology, 1993
- Pharmacia Allergy Research Foundation Annual Award, 1998
- Governor's Recognition Award, State of Ohio, 2002
- Best Doctors in America Award, 2003
- Awarded "2004 Best Doctors"
- Burton Zweimann Lectureship, American Academy of Allergy, Asthma, and Immunology, 2004
- Awarded "2005 Best Doctors"
- David A. Talmage Lectureship, Colorado Allergy Society, 2005
- E Mead Johnson Award, Society of Pediatric Research, 2007
- Best Doctors in America, 2008
Research
Eosinophils; chemokines
Research Grants and Contracts
Food Allergy and Anaphylaxis Network (FAAN), Epidemiology and molecular classification of eosinophilic esophagitis, 2005-2007, Principal Investigator.
National Institutes of Health, NIDDK, 1R01, Mechanistic analysis of eosinophilic esophagitis, 2005-2010, Co-Investigator.
Cincinnati Children's Translational Research Initiative, Eotaxin-3 in eosinophilic esophagitis, 2006-2007.
National Institutes of Health, NIAID Center Grant (Project 2), Epithelial-derived eotaxin 3 and eosinophilic esophagitis, 2006-2011, Co-Investigator.
Food Allergy and Anaphylaxis Network (FAAN), Molecular analysis of eosinophilic esophagitis, 2007-2009, Principal Investigator.
National Institutes of Health, NIAID, R01 DK076893-01, IL-13 and eosinophilic esophagitis, 2007-2012, Principal Investigator.
Dana Foundation, Novel Genetic and Therapeutic approaches focusing on siglec-8 for the diagnosis and treatment of human idiopathic eosinophilic disorders, 2007-2010, Principal Investigator.
Publications, Most Recent
View Marc Rothenberg's publications at Cincinnati Children's as listed by PubMed.
Nizet V, Rothenberg ME.: Mitochondrial missile defense. Nat Med. 2008 Sep;14(9):910-2.
Debrosse C.W.; Rothenberg M.E.: Allergy and eosinophil-associated gastrointestinal disorders (EGID).Curr Opin Immunol. 2008 Aug 19. [Epub ahead of print]
Zimmermann N.; McBride M.L.; Yamada Y.; Hudson S.A.; Jones C.; Cromie K.D.; Crocker P.R.; Rothenberg M.E.; Bochner B.S.: Siglec-F antibody administration to mice selectively reduces blood and tissue eosinophils.Allergy, 2008 Sep; 63:1156-63.
Yamada Y.; Sanchez-Aguilera A.; Brandt E.B.; McBride M.; Al-Moamen N.J.; Finkelman F.D.; Williams D.A.; Cancelas J.A.; Rothenberg M.E.: FIP1L1/PDGFR{alpha} synergizes with SCF to induce systemic mastocytosis in a murine model of chronic eosinophilic leukemia/hypereosinophilic syndrome.Blood, 2008 Jun 6.
Johnson T.R.; Rothenberg M.E.; Graham B.S.: Pulmonary eosinophilia requires interleukin-5, eotaxin-1, and CD4+ T cells in mice immunized with respiratory syncytial virus G glycoprotein. J Leukoc Biol, 2008 Sep;84:748-59.
Fulkerson P.C.; Rothenberg M.E.: Origin, regulation and physiological function of intestinal oeosinophils. Best Pract Res Clin Gastroenterol, 2008;22:411-23.
Stein M.L.; Villanueva J.M.; Buckmeier B.K.; Yamada Y.; Filipovich A.H.; Assa'ad A.H.; Rothenberg M.E.: Anti-IL-5 (mepolizumab) therapy reduces eosinophil activation ex vivo and increases IL-5 and IL-5 receptor levels.J Allergy Clin Immunol, 2008 Jun;121:1473-83, 1483.e1-4.
Rothenberg M.E.; Klion A.D.; Roufosse F.E.; Kahn J.E.; Weller P.F.; Simon H.U.; Schwartz L.B.; Rosenwasser L.J.; Ring J.; Griffin E.F.; Haig A.E.; Frewer P.I.; Parkin J.M.; Gleich G.J.: Treatment of patients with the hypereosinophilic syndrome with mepolizumab.N Engl J Med, 2008 Mar 20;358:1215-28.
Rothenberg M.E.: 2007 E. Mead Johnson Award: Scientific Pursuit of the Allergy Problem.Pediatr Res, 2008 Jul;64:110-5.
Munitz A.; McBride M.L.; Bernstein J. S.; Rothenberg M.E.: A dual activation and inhibition role for the paired immunoglobulin-like receptor B (PIR-B) in eosinophils.Blood, 2008 Jun 15;111:5694-703.
Munitz A.; Brandt E.B.; Mingler M.; Finkelman F.D.; Rothenberg M.E.: Distinct roles for IL-13 and IL-4 via IL-13 receptor alpha1 and the type II IL-4 receptor in asthma pathogenesis.Proc Natl Acad Sci USA, 2008 May 20;105:7240-5.
Mishra A.; Wang M.; Pemmaraju V.R.; Collins M.H.; Fulkerson P.C.; Abonia J.P.; Blanchard C.; Putnam P.E.; Rothenberg M.E.: Esophageal remodeling develops as a consequence of tissue specific IL-5-induced eosinophilia.Gastroenterology, 2008 Jan;134:204-14.
Hogan S.P.; Rothenberg M.E.: Dietary allergenic proteins and intestinal immunity: a shift from oral tolerance to sensitization.Clin Exp Allergy, 2008 Feb;38:229-32.
Hogan S.P.; Rosenberg H.F.; Moqbel R.; Phipps S.; Foster P.S.; Lacy P.; Kay A.B.; Rothenberg M.E.: Eosinophils: biological properties and role in health and disease.Clin Exp Allergy, 2008 May;38:709-50.
Herbert D.R.; Orekov T.; Perkins C.; Rothenberg M.E.; Finkelman F.D.: IL-4R{alpha} Expression by Bone Marrow-Derived Cells Is Necessary and Sufficient for Host Protection against Acute Schistosomiasis.J Immunol, 2008 Apr 1;180:4948-55.
Forbes E.E.; Groschwitz K.; Abonia J.P.; Brandt E.B.; Cohen E.; Blanchard C.; Ahrens R.; Seidu L.; McKenzie A.; Strait R.; Finkelman F.D.; Foster P.S.; Matthaei K.I.; Rothenberg M.E.; Hogan S.P.: IL-9- and mast cell-mediated intestinal permeability predisposes to oral antigen hypersensitivity.J Exp Med, 2008 Apr 14;205:897-913.
Collins M.H.; Blanchard C.; Abonia J.P.; Kirby C.; Akers R.; Wang N.; Putnam P.E.; Jameson S.C.; Assa'ad A.H.; Konikoff M.R.; Stringer K.F.; Rothenberg M.E.: Clinical, Pathologic, and Molecular Characterization of Familial Eosinophilic Esophagitis Compared With Sporadic Cases.Clin Gastroenterol Hepatol, 2008 Jun;6:621-9.
Brandt E.B.; Mingler M.K.; Stevenson M.D.; Wang N.; Khurana Hershey G.K.; Whitsett J.A.; Rothenberg M.E.: Surfactant protein D alters allergic lung responses in mice and human subjects.J Allergy Clin Immunol, 2008 May;121:1140-1147.e2.
Blanchard C.; Rothenberg M.E.: Basic pathogenesis of eosinophilic esophagitis.Gastrointest Endosc Clin N Am, 2008 Jan;18:133-43; x.
Zuo L.; Rothenberg M.E.: Gastrointestinal eosinophilia.Immunol Allergy Clin North Am, 2007 Aug;27(3):443-55.
Simson L.; Ellyard J.I.; Dent L.A.; Matthaei K.I.; Rothenberg M.E.; Foster P.S.; Smyth M.J.; Parish C.R.: Regulation of carcinogenesis by IL-5 and CCL11: a potential role for eosinophils in tumor immune surveillance.J Immunol, 2007 Apr 1;178:4222-9.
Rothenberg M.E.; Cohen M.B.: An eosinophil hypothesis for functional dyspepsia.Clin Gastroenterol Hepatol, 2007 Oct;5:1147-8.
Rothenberg M.E.: Eosinophils in the new millennium.J Allergy Clin Immunol, 2007 Jun;119:1321-2.
Munitz A.; Bachelet I.; Finkelman F.D.; Rothenberg M.E.; Levi-Schaffer F.: CD48 is critically involved in allergic eosinophilic airway inflammation.Am J Respir Crit Care Med, 2007 May 1;175:911-8.
Mishra A.; Wang M.; Schlotman J.; Nikolaidis N.M.; DeBrosse C.W.; Karow M.L.; Rothenberg M.E.: Resistin-like molecule-beta is an allergen-induced cytokine with inflammatory and remodeling activity in the murine lung.Am J Physiol Lung Cell Mol Physiol, 2007 Aug;293:L305-13.
Mishra A.; Schlotman J.; Wang M.; Rothenberg M.E.: Critical role for adaptive T cell immunity in experimental eosinophilic esophagitis in mice.J Leukoc Biol 2007 Apr;81:916-24.
McGraw D.W.; Elwing J.M.; Fogel K.M.; Wang W.C.; Glinka C.B.; Mihlbachler K.A.; Rothenberg M.E.; Liggett S.B.: Crosstalk between Gi and Gq/Gs pathways in airway smooth muscle regulates bronchial contractility and relaxation.J Clin Invest 2007 May;117:1391-8.
Furuta G.T.; Liacouras C.A.; Collins M.H.; Gupta S.K.; Justinich C.; Putnam P.E.; Bonis P.; Hassall E.; Straumann A.; Rothenberg M.E.: Eosinophilic esophagitis in children and adults: a systematic review and consensus recommendations for diagnosis and treatment.Gastroenterology, 2007 Oct;133:1342-63.
Bullock J.Z.; Villanueva J.M.; Blanchard C.; Filipovich A.H.; Putnam P.E.; Collins M.H.; Risma K.A.; Akers R.M.; Kirby C.L.; Buckmeier B.K.; Assa'ad A.H.; Hogan S.P.; Rothenberg M.E.: Interplay of adaptive th2 immunity with eotaxin-3/c-C chemokine receptor 3 in eosinophilic esophagitis.J Pediatr Gastroenterol Nutr, 2007 Jul;45:22-31.
Blanchard C.; Mingler M.K.; Vicario M.; Abonia J.P.; Wu Y.Y.; Lu T.X.; Collins M.H.; Putnam P.E.; Wells S.I.; Rothenberg M.E.: IL-13 involvement in eosinophilic esophagitis: transcriptome analysis and reversibility with glucocorticoids.J Allergy Clin Immunol, 2007 Dec;120:1292-300.
Bergeron C.; Boulet L.P.; Page N.; Laviolette M.; Zimmermann N.; Rothenberg M.E.; Hamid Q.: Influence of cigarette smoke on the arginine pathway in asthmatic airways: increased expression of arginase I.J Allergy Clin Immunol, 2007 Feb;119:391-7.
Assa'ad A.H.; Putnam P.E.; Collins M.H.; Akers R.M.; Jameson S.C.; Kirby C.L.; Buckmeier B.K.; Bullock J.Z.; Collier A.R.; Konikoff M.R.; Noel R.J.; Guajardo J.R.; Rothenberg M.E.: Pediatric patients with eosinophilic esophagitis: an 8-year follow-up.J Allergy Clin Immunol, 2007 Mar;119:731-8.
Zimmermann N.; Rothenberg M.E.: The arginine-arginase balance in asthma and lung inflammation.Eur J Pharmacol, 2006 Mar 8;533:253-62.
Yang M.; Rangasamy D.; Matthaei K.I.; Frew A.J.; Zimmmermann N.; Mahalingam S.; Webb D.C.; Tremethick D.J.; Thompson P.J.; Hogan S.P.; Rothenberg M.E.; Cowden W.B.; Foster P.S.: Inhibition of arginase I activity by RNA interference attenuates IL-13-induced airways hyperresponsiveness.J Immunol, 2006 Oct 15;177:5595-603.
Yamada Y.; Rothenberg M.E.; Lee A.W.; Akei H.S.; Brandt E.B.; Williams D.A.; Cancelas J.A.: The FIP1L1-PDGFRA fusion gene cooperates with IL-5 to induce murine hypereosinophilic syndrome (HES)/chronic eosinophilic leukemia (CEL)-like disease.Blood, 2006 May 15;107:4071-9.
Stein M.L.; Collins M.H.; Villanueva J.M.; Kushner J.P.; Putnam P.E.; Buckmeier B.K.; Filipovich A.H.; Assa'ad A.H.; Rothenberg M.E.: Anti-IL-5 (mepolizumab) therapy for eosinophilic esophagitis.J Allergy Clin Immunol, 2006 Dec;118:1312-9.
Rothenberg M.E.; Hogan S.P.: The eosinophil.Annu Rev Immunol, 2006;24:147-74.
Rothenberg M.E.; Doepker M.P.; Lewkowich I.P.; Chiaramonte M.G.; Stringer K.F.; Finkelman F.D.; MacLeod C.L.; Ellies L.G.; Zimmermann N.: Cationic amino acid transporter 2 regulates inflammatory homeostasis in the lung.Proc Natl Acad Sci USA 2006 Oct 3;103:14895-900.
Nikolaidis N.M.; Wang T.C.; Hogan S.P.; Rothenberg M.E.: Allergen induced TFF2 is expressed by mucus-producing airway epithelial cells but is not a major regulator of inflammatory responses in the murine lung.Exp Lung Res, 2006 Nov-Dec;32:483-97.
Munitz A.; Bachelet I.; Eliashar R.; Khodoun M.; Finkelman F.D.; Rothenberg M.E.; Levi-Schaffer F.: CD48 is an allergen and IL-3-induced activation molecule on eosinophils.J Immunol, 2006 Jul 1;177:77-83.
Letuve S.; Lajoie-Kadoch S.; Audusseau S.; Rothenberg M.E.; Fiset P.O.; Ludwig M.S.; Hamid Q.: IL-17E upregulates the expression of proinflammatory cytokines in lung fibroblasts.J Allergy Clin Immunol, 2006 Mar;117:590-6.
Konikoff M.R.; Noel R.J.; Blanchard C.; Kirby C.; Jameson S.C.; Buckmeier B.K.; Akers R.; Cohen M.B.; Collins M.H.; Assa'ad A.H.; Aceves S.S.; Putnam P.E.; Rothenberg M.E.: A randomized, double-blind, placebo-controlled trial of fluticasone propionate for pediatric eosinophilic esophagitis.Gastroenterology, 2006 Nov;131:1381-91.
Konikoff M.R.; Blanchard C.; Kirby C.; Buckmeier B.K.; Cohen M.B.; Heubi J.E.; Putnam P.E.; Rothenberg M.E.: Potential of blood eosinophils, eosinophil-derived neurotoxin, and eotaxin-3 as biomarkers of eosinophilic esophagitis.Clin Gastroenterol Hepatol, 2006 Nov;4:1328-36.
Klion A.D.; Bochner B.S.; Gleich G.J.; Nutman T.B.; Rothenberg M.E.; Simon H.U.; Wechsler M.E.; Weller P.F.; The Hypereosinophilic Syndromes Working Group: Approaches to the treatment of hypereosinophilic syndromes: a workshop summary report.J Allergy Clin Immunol, 2006 Jun;117:1292-302.
Hogan S.P.; Seidu L.; Blanchard C.; Groschwitz K.; Mishra A.; Karow M.L.; Ahrens R.; Artis D.; Murphy A.J.; Valenzuela D.M.; Yancopoulos G.D.; Rothenberg M.E.: Resistin-like molecule beta regulates innate colonic function: barrier integrity and inflammation susceptibility.J Allergy Clin Immunol, 2006 Jul;118:257-68.
Hogan S.P.; Rothenberg M.E.: Eosinophil Function in Eosinophil-associated Gastrointestinal Disorders.Curr Allergy Asthma Rep, 2006 Feb;6:65-71.
Fulkerson P.C.; Fischetti C.A.; Rothenberg M.E.: Eosinophils and CCR3 regulate interleukin-13 transgene-induced pulmonary remodeling.Am J Pathol, 2006 Dec;169:2117-26.
Fulkerson P.C.; Fischetti C.A.; McBride M.L.; Hassman L.M.; Hogan S.P.; Rothenberg M.E.: A central regulatory role for eosinophils and the eotaxin/CCR3 axis in chronic experimental allergic airway inflammation.Proc Natl Acad Sci USA, 2006 Oct 31;103:16418-23.
Fulkerson P.C.; Fischetti C.A.; Hassman L.M.; Nikolaidis N.M.; Rothenberg M.E.: Persistent effects induced by IL-13 in the lung.Am J Respir Cell Mol Biol, 2006 Sep;35:337-46.
Forbes E.; Hulett M.; Ahrens R.; Wagner N.; Smart V.; Matthaei K.I.; Brandt E.B.; Dent L.A.; Rothenberg M.E.; Tang M.; Foster P.S.; Hogan S.P.: ICAM-1-dependent pathways regulate colonic eosinophilic inflammation.J Leukoc Biol, 2006 Aug;80:330-41.
Dixon H.; Blanchard C.; Deschoolmeester M.L.; Yuill N.C.; Christie J.W.; Rothenberg M.E.; Else K.J.: The role of Th2 cytokines, chemokines and parasite products in eosinophil recruitment to the gastrointestinal mucosa during helminth infection.Eur J Immunol, 2006 Jul;36:1753-63.
DeBrosse C.W.; Case J.W.; Putnam P.E.; Collins M.H.; Rothenberg M.E.: Quantity and distribution of eosinophils in the gastrointestinal tract of children.Pediatr Dev Pathol, 2006 May-Jun;9:210-8.
Brandt E.B.; Zimmermann N.; Muntel E.E.; Yamada Y.; Pope S.M.; Mishra A.; Hogan S.P.; Rothenberg M.E.: The alpha4bbeta7-integrin is dynamically expressed on murine eosinophils and involved in eosinophil trafficking to the intestine.Clin Exp Allergy, 2006 Apr;36:543-53.
Brandt E.B.; Scribner T.A.; Akei H.S.; Rothenberg M.E.: Experimental gastrointestinal allergy enhances pulmonary responses to specific and unrelated allergens.J Allergy Clin Immunol, 2006 Aug;118:420-7.
Blanchard C.; Wang N.; Stringer K.F.; Mishra A.; Fulkerson P.C.; Abonia J.P.; Jameson S.C.; Kirby C.; Konikoff M.R.; Collins M.H.; Cohen M.B.; Akers R.; Hogan S.P.; Assa'ad A.H.; Putnam P.E.; Aronow B.J.; Rothenberg M.E.: Eotaxin-3 and a uniquely conserved gene-expression profile in eosinophilic esophagitis.J Clin Invest, 2006 Feb;116:536-47.
Blanchard C.; Wang N.; Rothenberg M.E.: Eosinophilic esophagitis: pathogenesis, genetics, and therapy.J Allergy Clin Immunol, 2006 Nov;118:1054-9.
Akei H.S.; Brandt E.B.; Mishra A.; Strait R.T.; Finkelman F.D.; Warrier M.R.; Hershey G.K.; Blanchard C.; Rothenberg M.E.: Epicutaneous aeroallergen exposure induces systemic TH2 immunity that predisposes to allergic nasal responses.J Allergy Clin Immunol, 2006 Jul;118:62-9.
Zimmermann N.; Doepker M.P.; Witte D.P.; Stringer K.F.; Fulkerson P.C.; Pope S.M.; Brandt E.B.; Mishra A.; King N.E.; Nikolaidis N.M.; Wills-Karp M.; Finkelman F.D.; Rothenberg M.E.: Expression and regulation of small proline-rich protein 2 in allergic inflammation.Am J Respir Cell Mol Biol, 2005 May;32:428-35.
Zimmermann N.; Colyer J.L.; Koch L.E.; Rothenberg M.E.: Analysis of the CCR3 promoter reveals a regulatory region in exon 1 that binds GATA-1.BMC Immunol, 2005 Apr 4;6:7.
Xanthakos S.A.; Schwimmer J.B.; Melin-Aldana H.; Rothenberg M.E.; Witte D.P.; Cohen M.B.: Prevalence and outcome of allergic colitis in healthy infants with rectal bleeding: a prospective cohort study.J Pediatr Gastroenterol Nutr, 2005 Jul;41:16-22.
Sutton S.A.; Assa'ad A.H.; Rothenberg M.E.: Anti-IL-5 and hypereosinophilic syndromes.Clin Immunol, 2005 Apr;115:51-60.
Spergel J.; Rothenberg M.E.; Fogg M.: Eliminating eosinophilic esophagitis.Clin Immunol, 2005 May;115:131-2.
Simons J.E.; Rothenberg M.E.; Lawrence R.A.: Eotaxin-1-regulated eosinophils have a critical role in innate immunity against experimental Brugia malayi infection.Eur J Immunol, 2005 Jan;35:189-97.
Prescott V.E.; Campbell P.M.; Moore A.; Mattes J.; Rothenberg M.E.; Foster P.S.; Higgins T.J.; Hogan S.P.: Transgenic expression of bean alpha-amylase inhibitor in peas results in altered structure and immunogenicity.J Agric Food Chem, 2005 Nov 16;53:9023-30.
Pope S.M.; Zimmermann N.; Stringer K.F.; Karow M.L.; Rothenberg M.E.: The eotaxin chemokines and CCR3 are fundamental regulators of allergen-induced pulmonary eosinophilia.J Immunol, 2005 Oct 15;175:5341-50.
Pope S.M.; Fulkerson P.C.; Blanchard C.; Akei H.S.; Nikolaidis N.M.; Zimmermann N.; Molkentin J.D.; Rothenberg M.E.: Identification of a cooperative mechanism involving interleukin-13 and eotaxin-2 in experimental allergic lung inflammation.J Biol Chem, 2005 Apr 8;280:13952-61.
Ort T.; Arjona A.A.; MacDougall J.R.; Nelson P.J.; Rothenberg M.E.; Wu F.; Eisen A.; Halvorsen Y.D.: Recombinant human FIZZ3/resistin stimulates lipolysis in cultured human adipocytes, mouse adipose explants, and normal mice.Endocrinology, 2005 May;146(5):2200-9.
Noel R.J.; Rothenberg M.E.: Eosinophilic esophagitis.Curr Opin Pediatr, 2005 Dec;17:690-4.
Fulkerson P.C.; Zhu H.; Williams D.A.; Zimmermann N.; Rothenberg M.E.: CXCL9 inhibits eosinophil responses by a CCR3- and Rac2-dependent mechanism.Blood, 2005 Jul 15;106:436-43.
Fulkerson P.C.; Rothenberg M.E.; Hogan S.P.: Building a better mouse model: experimental models of chronic asthma.Clin Exp Allergy, 2005 Oct;35:1251-3.
Finkelman F.D.; Yang M.; Perkins C.; Schleifer K.; Sproles A.; Santeliz J.; Bernstein J.A.; Rothenberg M.E.; Morris S.C.; Wills-Karp M.: Suppressive effect of IL-4 on IL-13-induced genes in mouse lung.J Immunol, 2005 Apr 15;174:4630-8.
Finkelman F.D.; Rothenberg M.E.; Brandt E.B.; Morris S.C.; Strait R.T.: Molecular mechanisms of anaphylaxis: lessons from studies with murine models.J Allergy Clin Immunol, 2005 Mar;115:449-57; quiz 458.
Blanchard C.; Mishra A.; Saito-Akei H.; Monk P.; Anderson I.; Rothenberg M.E.: Inhibition of human interleukin-13-induced respiratory and oesophageal inflammation by anti-human-interleukin-13 antibody (CAT-354).Clin Exp Allergy 2005 Aug;35:1096-103.
Akei H.S.; Mishra A.; Blanchard C.; Rothenberg M.E.: Epicutaneous antigen exposure primes for experimental eosinophilic esophagitis in mice.Gastroenterology, 2005 Sep;129:985-94.
Professional Organization Memberships
- Massachusetts Medical Society, 1983-1996
- Physicians for Social Responsibility, 1983-1988
- American Association for the Advancement of Science, 1987-present
- American Academy of Pediatrics, 1990-present
- American Academy of Allergy, Asthma and Immunology, 1993-present
- American Association of Immunologists, 1998-present
- Pharmacia Allergy Research Foundation, 1998-present
- Society for Mucosal Immunology, 1998-present
- Society for Pediatric Research, 1998-present
- American Society of Clinical Investigation, 2000-present
- American Pediatric Society, 2000-present
- American Society for Biochemistry and Molecular Biology, 2005-present
- American College of Allergy, Asthma and Immunology, 2006-present
- American Association of Physicians, 2007- present
Books
Rothenberg ME, editor of Chemokines in Allergic Diseases, New York: Marcel Dekker, 2000.
Recent Book Chapters
Rothenberg ME. Eotaxin. In: Thomas E. Creighton, ed. The Encyclopedia of Molecular Medicine, John Wiley & Sons, Inc., New York, 2002; pp 1181-1185.
Zimmermann N, Rothenberg ME. Therapeutic Targeting of Chemokines and Chemokine Receptors. In: Agosti J, Sheffer AL, eds. Biotherapeutic Approaches to Asthma. New York, Marcel Dekker, Inc; 2002. pp. 167-210.
Zimmermann N, Rothenberg ME. Role of the Eotaxin Subfamily of Chemokines in Allergic Eosinophilic Inflammation. In: Eissa NT, Huston DP, Lenfant C, eds. Lung Biology in Health and Disease: Therapeutic Targets of Airway Inflammation. New York: Marcel Dekker, Inc., 2003 pp 421-463.
Guajardo JR, Rothenberg ME. Eosinophil-Associated Gastrointestinal Disorders: Clinical Features and Pathogenesis. In: Metcalfe D, Sampson H, Simon RA (eds). Food Allergy: Adverse Reactions to Foods and Food Additives, (3rd Edition) Malden, Massachusetts: Blackwell Publishing, Inc., 2003, pp 217-226.
Rothenberg ME. Inflammatory Effector Cells / Cell Migration. In: Leung DYM, Geha R, Sampson H, Szefler A (eds): Pediatric Allergy: Principles and Practice St. Louis: Mosby, 2003, pp 51-68.
Rothenberg ME, Hogan SP. The eosinophil. Annu Rev Immunology, 2006; 24:147-74.
Fulkerson PC, Rothenberg ME. Chemokines CXC: CXCL9 (mig). In: Laurent GJ, Shapiro SD (eds): Encyclopedia of Respiratory Medicine, London: Elsevier Science, 2006, pp 398-401.
Rothenberg ME. Eosinophilic Syndromes. In: Goldman L, Ausiello D (eds): Cecil Textbook of Medicine, (23rd Edition) Philadelphia: WB Saunders, in press.
Rothenberg ME, Furuta GT. Eosinophilic Esophagitis. In: Yamada T (ed), Alpers DH, Kalloo A, Kaplowitz N. Owyang C, Powell D (associate editors): Textbook of Gastroenterology (5th Edition), in press.
Zuo Li, Rothenberg ME. Eosinophil Associated Gastrointestinal Disorders (EGID). In: Rich RR, Shearer WT, Fleisher TA, Schroeder H, Weyand C, Frew AJ (eds): Clinical Immunology (3rd Edition), Edinburgh, UK: Martin Mellor Publishing Services, Ltd, in press.
Rothenberg ME. Eosinophilic Gastroenteropathies. In: Adkinson NF, Busse WW, Bochner BS, Holgate ST, Simons FER, Lemanske RF (eds): Middleton's Allergy (7th Edition), London: Elsevier, in press.
Rothenberg ME. Biology of Eosinophils. In: Adkinson NF, Busse WW, Bochner BS, Holgate ST, Simons FER, Lemanske RF (eds): Middleton's Allergy (7th Edition), London: Elsevier, in press.
Rothenberg ME. Eosinophils. In: Mestecky J, Bienenstock J, Lamm ME, Mayer L, McGhee JR, Strober W (eds): Mucosal Immunology, London: Elsevier Science, 2005, pp 717-735 (Vol. 1).
Rothenberg ME, Hogan SP: The eosinophil, Annu Rev Immunology, 2006; 24:147-74.
Fulkerson PC, Rothenberg ME. Chemokines CXC: CXCL9 (mig). In: Laurent GJ, Shapiro SD (eds): Encyclopedia of Respiratory Medicine, London: Elsevier Science, 2006, pp 398-401.
Rothenberg ME. Eosinophilic Syndromes. In: Goldman L, Ausiello D (eds): Cecil Medicine: Expert Consult: Online and Print (Cecil Textbook of Medicine), (23rd Edition) Philadelphia: WB Saunders, 2007.
Zuo Li, Rothenberg ME. Eosinophil Associated Gastrointestinal Disorders (EGID). In: Rich RR, Shearer WT, Fleisher TA, Schroeder H, Weyand C, Frew AJ (eds): Clinical Immunology (3rd Edition), Edinburgh, UK: Martin Mellor Publishing Services, Ltd 2008.
Rothenberg ME, Furuta GT. Eosinophilic Esophagitis. In: Yamada T (ed), Alpers DH, Kalloo A, Kaplowitz N. Owyang C, Powell D (associate editors): Textbook of Gastroenterology (5th Edition), in press.
Rothenberg ME. Eosinophilic Gastroenteropathies. In: Adkinson NF, Busse WW, Bochner BS, Holgate ST, Simons FER, Lemanske RF (eds): Middleton’s Allergy (7th Edition), London: Elsevier, in press.
Rothenberg ME. Biology of Eosinophils. In: Adkinson NF, Busse WW, Bochner BS, Holgate ST, Simons FER, Lemanske RF (eds): Middleton’s Allergy (7th Edition), London: Elsevier, in press.
Special Interests
Eosinophilia; eosinophilic disorders; asthma; allergy; food allergy
Scientific Reviews
Editorial Boards
Scientific Expert Panel
Scientific and Medical Boards
- 2000-2003 Gift of Life Foundation (a bone marrow donor registry)
- 2001- American Partnership for Eosinophilic Disorders
- 2002- International Advisory Board for "Eosinophil Rising
- 2003 3rd Biennial International Eosinophil Symposium
- 2003- Executive Committee, International Eosinophil Society
- 2006- The International Gastrointestinal Eosinophiilc Researchers (TIGER) Steering Committee
Recent Invited Lectures and Symposia
2001
- VIII Symposium on Immunological, Chemical and Clinical Problems on Food Allergy, Venice, Italy, Invited Speaker
- Meakins-Christie Workshop on Pathogenesis and Treatment of Asthma and COPD: Current and Future Aspects, Montreal, Canada, Invited Speaker
- The Toxicology Forum 2001 Annual Winter Meeting, Washington, DC, Invited Speaker
- ILSI Health and Environmental Sciences Institute, Protein Allergenicity Subcommittee, Washington, DC, Invited Participant
- Immunobiology Seminar Series, Mt. Sinai Medical Center, New York, NY, Invited Speaker
- Immunology Seminar Series, Beirne B. Carter Center for Immunology Research, University of Virginia Health System, Charlottesville, Virginia, Invited Speaker
- American Gastroenterological Association, Digestive Disease Week 2001, Atlanta, Georgia, Invited Speaker
- International Eosinophil Society, Eosinophil 2001 International Symposium, Banff, Alberta, Canada, Invited Speaker
- Schneider's Children's Hospital, Israel, Invited Speaker
- Aspen Allergy Conference, Given Institute of Pathobiology, Aspen, Colorado, Invited Speaker
- John Curtin School of Medical Research, Australian National University, Canberra, Australia, Invited Speaker
2002
- 5th Annual Meakins Christie Workshop on Pathogenesis and Treatment of Asthma, Montreal, Canada, Invited Speaker
- American Academy of Allergy, Asthma and Immunology annual meeting, Postgraduate Plenary Session, Invited Speaker
- 18th Annual Dr. Dorothy Wiselberg Seminar, The Respiratory Division and the Meakins-Christie Laboratories, Montreal, Canada, Invited Speaker
- Southeastern Allergy, Asthma and Immunology Society, 57th Annual Meeting, Sea Island, Georgia, Invited Speaker
- St. Louis University, Cardinal Glennon Children's Hospital, Pediatric Grand Rounds, St. Louis, Missouri, Invited Speaker
- NIH, Laboratory of Allergic Disease, Invited Speaker
- Johns Hopkins Medical Center, Invited Speaker
- Cleveland Clinic, Invited Speaker
2003
- Meakins Christie Workshop on Asthma and COPD, Montreal, Quebec Canada, Invited Speaker
- American Academy of Allergy, Asthma and Immunology annual meeting, Workshop, Denver, Colorado, Invited Speaker
- The Emery Educational Society of Cincinnati Children's Hospital Medical Center, Invited Speaker
- University of Southern California ENT Conference, Invited Speaker
- University of California at Los Angeles, Department of Allergy and Immunology Conference, Invited Speaker
- Federation of Clinical Immunology Societies (FOCIS) annual meeting, Paris, France, Invited Speaker
- University of Alabama Birmingham, Invited Speaker
- McMaster University, Distinguished Speaker Series, Hamilton, Ontario, Canada, Invited Speaker
- Arginine Symposium, Southampton Princess Hotel, Bermuda, Invited Speaker
- Hypereosinophil Syndromes Workshop, Snowmass Village, Colorado, Invited Speaker
- The 3rd International Eosinophil Symposium – Eosinophil Rising, Snowmass, Colorado, Invited Speaker and Moderator
- World Allergy Organization (WAO) Congress – XVIII ICACI, Vancouver, Canada, Invited Plenary Speaker
2004
- Building a Better World Through Medicine II, Jerusalem, Israel
- University of Illinois and Rush University, Division of Allergy and Immunology, Chicago, Illinois, Invited Speaker
- Northwestern University, Division of Allergy, Chicago, Illinois, Invited Speaker
- American Academy of Allergy, Asthma and Immunology annual meeting, Postgraduate Symposium, The Burton Zweiman Lectureship, San Francisco, California, Invited Speaker
- American Academy of Allergy, Asthma and Immunology annual meeting, Workshop, San Francisco, California, Invited Plenary Speaker
- American Gastroenterological Association, Digestive Disease Week 2004, New Orleans, Louisiana, Invited Speaker
- Allergy Fellows Symposium, Orlando, Florida, Invited Speaker
- Israel Allergy Academy, Invited Speaker
- Department of Pediatrics, Asaf Medical Center, Ramla, Israel, Invited Speaker
- Tel Aviv Sourasky Medical Center, Israel, Department of Gastroenterology, Invited Speaker
- Kfar Saba Medical Center, Department of Medicine, Israel, Grand Rounds, Invited Speaker
- XXIII Annual Congress of the European Academy of Allergology and Clinical Immunology, Amsterdam, Invited Speaker
- Department of Medicine, Asaf Medical Center, Ramla, Israel, Invited Speaker
- Department of Gastroenterology, Tel Aviv University, Israel, Invited speaker
- Department of Pediatrics, Pediatric Grand Rounds, Schneider's Children's Hospital Medical Center, Israel, Invited Speaker
2005
- Controversies and New Findings in Allergies CYNA Meeting, Madrid, Spain, Invited Speaker
- Biennial Congress of the International Eosinophil Society, Bern, Switzerland, Invited Speaker
- Federation of Clinical Immunology Societies (FOCIS) annual meeting, Boston, Invited Speaker
- Idea Congress s.r.l Rome, DAM 8 2005, Rome, Italy, Invited Speaker
- Aspen Allergy Conference, Aspen, Colorado, Invited Speaker
- Japanese Society for Immunology (JSI) Presidential Symposium, Yokahama, Japan, Invited Speaker
- American College of Allergy, Asthma and Immunology, Annual Meeting, Invited Plenary Speaker
2006
- American Academy of Allergy, Asthma and Immunology, Annual Meeting, Miami, Florida, Invited Speaker
- Keystone Symposium on Allergy, Allergic Inflammation and Asthma, Breckenridge, Colorado, Invited Speaker
- Digestive Disease Week / Eosinophilic Gastrointestinal Disorders meeting, Los Angeles, California, Invited Speaker
- Division of Allergy and Immunology, University of Michigan, Ann Arbor, Michigan, Invited Speaker
- Eosinophils in GI Health and Disease, Children's Hospital of Philadelphia, Invited Speaker
- American Partnership for Eosinophilic Disorders (APFED) Annual Meeting, Philadelphia, Pennsylvania, Invited Speaker
- Blue Grass Allergy Society, Lexington, Kentucky, Invited Speaker
- Israeli Association of Allergy and Clinical Immunology (Israeli Medical Association), Invited Speaker
- North American Society Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN) Postgraduate Course, Orlando, Florida, Invited Speaker
- First International Gastrointestinal Eosinophilic Research Symposium (FIGERS), Orlando, Florida, Invited Speaker
- American College of Allergy, Asthma and Immunology, Annual Scientific Meeting, Philadelphia, Pennsylvania, Invited Speaker
- American Society of Hematology annual meeting, Orlando, Florida, Invited Speaker
2007
- Boston City Wide Allergy and Immunology Rounds, Boston, Massachusetts, Invited Speaker
- 10th Annual Meakins Christie Workshop on Asthma and COPD, Montreal, Quebec Canada, Invited Speaker
- American Academy of Allergy, Asthma and Immunology annual meeting, Workshop, San Diego, California, Invited Speaker
- American Academy of Allergy, Asthma and Immunology annual meeting, Symposium, San Diego, California, Invited Speaker
- Los Angeles Children’s Hospital Pediatric Grand Rounds – 4th Annual Carolyn and Warren Richards Allergy Lecture, Los Angeles, California, Invited Speaker
- International Eosinophil Society Annual Meeting, Salt Lake City, Utah, Invited Speaker
- Distinguished Speaker Seminar Series, National Jewish Hospital, Denver, Colorado, Invited Speaker
- Long Island Asthma and Allergy Society, Montauk, New York, Invited Speaker
2008
- Medical School Rounds, Sackler Medical School, Assaf-Harofeh, Medical Center, Israel
- Charles E. Reed Lecture, Mayo Clinic, Rochester, Minnesota
- American Academy of Allergy, Asthma, and Immunology Annual Meeting, Philadelphia, Pennsylvania, Invited Speaker
- 9th Annual Burton A. Shatz Visiting Professor Lecture, University of Washington University, St. Louis
Related Areas
This person works in these other areas at Cincinnati Children's Hospital Medical
Center:
