Yrina Rochman, PhD

Research Associate, Division of Allergy and Immunology
Instructor, UC Department of Pediatrics

yrina.rochman@cchmc.org

About

Biography

Yrina earned her PhD from the Hebrew University of Jerusalem. She completed her post-doctoral training in molecular immunology at National Institutes of Health in the laboratory of Dr. Warren Leonard, where she published several papers and reviews in high profile peer-reviewed journals. She is a recipient of the Lenfant Biomedical Award from NHLBI, NIH for outstanding research. Her research is focused on elucidating molecular mechanisms of immunological responses.

PhD: Hebrew University of Jerusalem, Israel, 2005.

Post-Doc Fellowship: NHLBI/National Institutes of Health, Bethesda, MD, 2005-2011.

Research Associate: Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2012-2013.

Research Instructor: Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2013-present.

Interests

Immunology

Publications

Allergen-specific mRNA-lipid nanoparticle therapy for prevention and treatment of experimental allergy in mice. Rochman, Y; Kotliar, M; Klingler, AM; Rochman, M; Alameh, M-G; Melamed, JR; Osswald, GA; Caldwell, JM; Felton, JM; Mack, LE; Hargis, J; Lewkowich, IP; Barski, A; Weissman, D; Rothenberg, ME. Journal of Clinical Investigation. 2025; 135(21).

TH2 cell compensatory effect following benralizumab treatment for eosinophilic gastritis. Ben-Baruch Morgenstern, N; Rochman, Y; Caldwell, JM; Collins, MH; Mukkada, VA; Putnam, PE; Bolton, SM; Kliewer, KL; Rothenberg, ME. Journal of Allergy and Clinical Immunology. 2024; 154(5):1325-1332.e2.

TSLP shapes the pathogenic responses of memory CD4+ T cells in eosinophilic esophagitis. Rochman, Y; Kotliar, M; Ben-Baruch Morgenstern, N; Barski, A; Wen, T; Rothenberg, ME. Science Signaling. 2023; 16(802):eadg6360.

The minichromosome maintenance complex drives esophageal basal zone hyperplasia. Rochman, M; Rochman, Y; Caldwell, JM; Mack, LE; Besse, JA; Manes, NP; Yoon, SH; Shoda, T; Nita-Lazar, A; Rothenberg, ME. JCI Insight. 2023; 8(17).

Local type 2 immunity in eosinophilic gastritis. Ben-Baruch Morgenstern, N; Shoda, T; Rochman, Y; Caldwell, JM; Collins, MH; Mukkada, V; Putnam, PE; Bolton, SM; Felton, JM; Rochman, M; Murray-Petzold, C; Kliewer, KL; Rothenberg, ME. Journal of Allergy and Clinical Immunology. 2023; 152(1):136-144.

Environmental allergens trigger type 2 inflammation through ripoptosome activation. Brusilovsky, M; Rochman, M; Rochman, Y; Caldwell, JM; Mack, LE; Felton, JM; Habel, JE; Porollo, A; Pasare, C; Rothenberg, ME. Nature Immunology. 2021; 22(10):1316-1326.

Single-cell RNA sequencing identifies inflammatory tissue T cells in eosinophilic esophagitis. Wen, T; Aronow, BJ; Rochman, Y; Rochman, M; Kc, K; Dexheimer, PJ; Putnam, P; Mukkada, V; Foote, H; Rehn, K; Darko, S; Douek, D; Rothenberg, ME. Journal of Clinical Investigation. 2019; 129(5):2014-2028.

TSLP signaling in CD4+ T cells programs a pathogenic T helper 2 cell state. Rochman, Y; Dienger-Stambaugh, K; Richgels, PK; Lewkowich, IP; Kartashov, AV; Barski, A; Khurana Hershey, GK; Leonard, WJ; Singh, H. Science Signaling. 2018; 11(521).