Health Topics

Primary Sclerosing Cholangitis (PSC)

In primary sclerosing cholangitis (PSC), the bile ducts (a type of passageway) inside and outside the liver become narrowed due to inflammation and scarring. As the scarring increases, the ducts become blocked. The ducts are important because they carry bile out of the liver.

Bile is a liquid that removes toxins from the body and helps break down fat in food. If the ducts are blocked, toxins in bile remain in the liver and damage liver cells. In addition, fat and vitamins A, D, E and K may not be well absorbed. Eventually, primary sclerosing cholangitis can cause liver failure.

Approximately three out of every 100,000 individuals in the world are diagnosed with sclerosing cholangitis.

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Long-Term Outlook


Last Updated: 10/2012