Hyper IgE Syndrome (Job’s Syndrome)

IgE, or immunoglobulin E, is an antibody that helps protect our body from certain infections. IgE is also made by the body and can cause allergic reactions. 

IgE can lead to allergic symptoms of:

    • Coughing, wheezing
    • Runny nose
    • Eye or throat irritation
    • Dry, red and itchy skin 

Job’s syndrome is a genetic alteration that can lead to a chronic skin rash (eczema) and chronic infections, especially in the skin and lung. 

Patients with hyper IgE have trouble fighting harmful bacteria. The patient may develop these symptoms:

  • Frequent skin infections
  • Recurrent abscesses
  • Dry, itchy skin (eczema)
  • Frequent pneumonia  

As a child gets older, watch for:

  • Delay in losing primary teeth
  • Large cysts in the lungs, called pneumatoceles
  • Poor bone formation
  • Increased broken bones (fractures)
  • Abnormal curvature of the spine (scoliosis)

How do you detect these complications?

Chest X-rays or chest CTs are done regularly to look for cysts in the lungs

While there is no cure for hyper IgE syndrome, treatment focuses on stopping the symptoms. Some common treatments are:

  • Antibiotics to treat infections
  • Cream medication for skin rash
  • Pulmonary (lung) monitoring with spirometry and imaging
  • Some patients may need to take medication every day to prevent infection
  • Some patients may need to get an IV medicine called IVIG. IVIG contains antibodies to fight future infections.  

Last Updated 07/2012