Services & Specialties

Immune Deficiency and Histiocytosis

Comprehensive Care for Children with Immune Deficiencies

The Immune Deficiency and Histiocytosis Program within the Division of Bone Marrow Transplantation and Immune Deficiency offers a unique combination of expert medical care, state-of-the-art testing capabilities and extensive research for children with immune deficiencies. Our team takes a comprehensive approach, working together to ensure that patients receive the most effective treatment and follow-up care.

Thorough Evaluation, Detailed Treatment Plan

As part of our program, we provide initial diagnoses, second opinions, immunologic testing and genetic profiles as well as expert medical care.

Immune deficiencies affect every patient differently and may involve many parts of the body. For instance, some children may have gastrointestinal problems, and others may have abnormalities in their lungs or liver. By reviewing the information unique to each patient, our team is able to schedule appointments with other relevant subspecialists in conjunction with the first evaluation in the Immune Deficiency Clinic.

A major strength of our program is that we offer a full range of immunologic testing not normally available within an individual center. Tests are analyzed quickly, and additional studies may be performed, as needed, during the initial evaluation visit.

Our specialists in immune deficiencies and histiocytoses are trained to manage each child’s care from diagnosis to cure. Therefore, we are able to offer continuous, comprehensive treatment overseen by the same doctor throughout this process. Patients also benefit from the coordinated expertise of other pediatric subspecialists within Cincinnati Children’s who work closely with the immune deficiency physician.

The initial comprehensive evaluation can take a few days and includes: 

  • A thorough patient history and physical examination
  • Blood tests
  • Tests to assess how the disease is affecting the child’s body
  • Consultation with specialists in other fields of pediatric medicine
  • An appointment with a social worker, who helps families connect with helpful resources

After reviewing the test results, members of the care team will talk with the family about the child’s health and treatment options. They also provide a written summary and treatment recommendations to the patient’s family and referring physician.


Our program is part of the Cincinnati Children’s Cancer and Blood Diseases Institute, which is ranked No. 3 in the nation for pediatric cancer care.

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In the Best of Hands

When Hannah was diagnosed with hemophagocytic lymphohistiocytosis (HLH), her family came to Cincinnati Children’s for world-class care.
When Hannah was diagnosed with hemophagocytic lymphohistiocytosis (HLH), her family came to Cincinnati Children’s for world-class care. Read More