Immune Deficiencies and Dysregulation
Research and Clinical Trials

Research That Leads to Innovation

The Immune Deficiency and Dysregulation Program at Cincinnati Children’s conducts clinical and laboratory research for all types of immune system diseases. Many of our doctors are involved with research, which means we can access new and emerging therapies for our patients to improve outcomes. We also work closely with Cincinnati Children’s Cancer and Blood Diseases Institute researchers to bring breakthrough treatments into our clinics.

We offer all our patients the opportunity to participate in the Immunodeficiency Registry. As part of this registry, patients can donate blood and other biological samples for research into immune deficiency and dysregulation disorders. We also offer observational studies for patients with HLH, SCID, CGD and immune dysregulation disorders as part of the Primary Immune Deficiency Treatment Consortium. An observational study tracks a patient’s progress without offering a different treatment or therapy.

Our program is also currently studying new treatments for a range of immune system diseases. See our open clinical trials for HLH, XIAP deficiency, SCID, bone marrow transplant and others.

Our researchers are working hard to help provide you with the best treatment options.
Our researchers are working to find the best treatment options.

Screening for Newborns

Physicians at Cincinnati Children’s, including Kimberly A. Risma, MD, PhD, helped develop follow-up guidelines for a test to screen newborns against severe combined immune deficiency disease (SCID), which Ohio has added to its list of mandatory infant screenings. 
Learn More