The Immune Deficiency and Histiocytosis Program at Cincinnati Children’s treats patients with more than 80 kinds of immune deficiencies and histiocytic disorders. Our physicians have developed treatment regimens that improve survival. Many of these approaches have become international standards of care.

The program’s specialists manage each stage of patient care, from immunologic diagnostic testing to curative strategies such as hematopoietic (blood or marrow) stem cell transplantation.

The following diseases are rare, but our specialists have extensive experience in their diagnosis and management: 

  • HLH (hemophagocytic lymphohistiocytosis) | Learn more about this disorder. | Visit the HLH Center of Excellence.
  • SCIDs (severe combined immunodeficiencies)
  • CGD (chronic granulomatous disease)
  • WAS (Wiskott-Aldrich syndrome)
  • CVID (common variable immunodeficiency)
  • Hypogammaglobulinemia
  • LCH (Langerhans cell histiocytosis) | Learn more about this disease. | Visit the Langerhans Cell Histiocytosis Center.
  • ALPS (autoimmune lymphoproliferative syndrome)
  • HIGM2-HIGM4 (autosomal recessive hyper IgM syndrome)
  • IPEX (immune dysregulation, polyendocrinopathy, enteritis, X-linked)
  • XLA (X-linked agammaglobulinemia)
  • HIM (X-linked-hyper IgM syndrome / X-linked CD40 ligand deficiency)
  • XLP (X-linked lymphoproliferative syndrome) | Learn more about this disease. | Visit the HLH Center of Excellence.
  • NEMO (X-linked NFkB essential modifier deficiency)
  • X-linked inhibitor of apoptosis (XIAP) deficiency
  • ADA2 deficiency
  • LRBA4 deficiency (rare autoimmune enteropathy)
  • Periodic fever syndromes, or “inflammasomopathies,” including diseases hallmarked by genetic abnormalities in the following genes:
    • TNFR1
    • NLRP3, causing crypyrin-associated periodic syndromes (CAPS) including neonatal-onset multisystem inflammatory disorder (NOMID)
    • MVK gene, causing hyper IgD syndrome
    • NLRC4