Hemophagocytic lymphohistiocytosis (HLH) is a disorder of the immune system in which too many infection-fighting cells are produced and activated, causing damage to organs. While rare, HLH is rapidly fatal. However, with prompt and accurate diagnosis and timely treatment, a cure is possible. 

Unfortunately, few physicians are knowledgeable about HLH, and it is often misdiagnosed or diagnosed too late. Without access to effective treatment, primarily bone marrow transplantation (BMT), most patients with HLH die. 

As the most experienced facility in the nation in treating HLH, Cincinnati Children’s has assembled a team of researchers, physicians, families who have faced an HLH diagnosis and philanthropists to create the HLH Center of Excellence. 

The center focuses on four core priorities: 

While HLH is rare, Cincinnati Children’s treats a large population of children with HLH. The clinical and research pioneers at Cincinnati Children’s are committed to changing the outcome for children with HLH.