Currently, Cincinnati Children’s is conducting many research studies that could change the face of diagnosis and care for HLH. We have six physician scientists who are focused solely on basic and translational research in HLH. Some of our ongoing innovative work includes: 

  • Development of an HLH gene chip
  • Novel protocol for initial treatment: HIT-HLH
  • Preclinical studies of gene therapy in PRF1 deficiency
  • Preclinical studies of small molecule targeted therapy 

While we already have strong collaborations with the National Institutes of Health (NIH) and other HLH centers in China, Japan, Vietnam, Canada and Sweden, we plan to further extend our scientific collaborations across Europe, Central and South America, and Asia. 

We are also working to increase research funding for HLH through industry grants, additional NIH funding and philanthropic support.

Published Research

> Read some of our HLH research articles from