As a pathologist, I work in a laboratory diagnosing illnesses. I relate the patient’s medical history to the laboratory findings, then analyze, discuss and diagnose. I never forget a challenging case, and I am always looking for opportunities to improve basic understanding of disease.
I was inspired to pursue my career by Edward A. Gall, MD, who was chairman of the Department of Pathology at the University of Cincinnati College of Medicine from 1948 to 1971. A. J. McAdams, MD, who was chief of pathology at Cincinnati Children’s Hospital from 1961 to 1995, also provided unflagging support and fostered an atmosphere of intellectual curiosity that attracted many outstanding faculty and dozens of trainees in Pediatric Pathology — many of whom became leaders in the field.
I have more than 50 years of experience in pediatric pathology at Cincinnati Children's. Continuing a long history of collaborative clinical research within the Division of Pathology, I focus on pathogenesis of childhood cancers, metabolic disease, liver disease and skeletal muscle disease in children and babies. My main clinical collaborators have been in gastroenterology and rheumatology. My research has resulted in more than 220 peer-reviewed publications, many published in prestigious pathology and clinical journals.
I was honored to be secretary-treasurer, and then president, of the Society for Pediatric Pathology. I also served as the chair of the Autopsy Committee for the College of American Pathologists.
In my free time, I enjoy my family by involving myself in their activities — gardening, sailing and having conversations around the dinner table.
MD: State University of New York, Buffalo, NY.
Residency: Rotating Intern, Cincinnati General Hospital, 1961-1962; Pathology, Cincinnati General Hospital, 1962-1966.
Certification: American Board of Pathology in Anatomic and Clinical Pathology, 1967 and 1968; Pediatric Pathology, 1990.
Dr. Bove has been a career academic pediatric pathologist at Cincinnati Children's since 1968. He functions as a surgical pathologist, autopsy consultant and electron microscopist with diverse clinical interests. His collaborations with faculty and fellows in many divisions have resulted in more than 180 peer-reviewed and more than 120 publications.
Pathology, Liver Tumor, Neuromuscular Disorders, Colorectal Disorders
Dr. Bove's current research focus is on pathogenesis of biliary atresia and other cholestatic disorders of infancy. He has long term research interests in the early stages of childhood neoplasia and childhood diseases of skeletal muscle and heart.
Risk of variceal hemorrhage and pretransplant mortality in children with biliary atresia. Hepatology. 2022; 76:712-726.
Stx4 is required to regulate cardiomyocyte Ca2+ handling during vertebrate cardiac development. 2022; 3.
Hypoplasia of Extrahepatic Biliary Tree and Intrahepatic Cholangiolopathy in Cystic Fibrosis Imperfectly Mimic Biliary Atresia in 4 Infants With Cystic Fibrosis and Kasai Portoenterostomy. American Journal of Surgical Pathology. 2021; 45:1499-1508.
Novel Pathogenic DNAH5 Variants in Primary Ciliary Dyskinesia: Association with Visceral Heterotaxia and Neonatal Cholestasis. Journal of Pediatric Genetics. 2021.
A Diet High in Fat and Fructose Induces Early Hepatic Mitochondrial Aging. Journal of Pediatric Gastroenterology and Nutrition. 2021; 73:99-102.
Early Aberrant Angiogenesis Due to Elastic Fiber Fragmentation in Aortic Valve Disease. Journal of Cardiovascular Development and Disease. 2021; 8.
Non-Alcoholic Fatty Liver Disease in Children. Liver Disease in Children. 2021.
Hepatic LDL receptor-related protein-1 deficiency alters mitochondrial dynamics through phosphatidylinositol 4,5-bisphosphate reduction. Journal of Biological Chemistry. 2021; 296.
Longitudinal Outcomes in Young Patients with Alpha-1-Antitrypsin Deficiency with Native Liver Reveal that Neonatal Cholestasis is a Poor Predictor of Future Portal Hypertension. Journal of Pediatrics. 2020; 227:81-86.e4.
Congenital Portosystemic Shunts in Children: Associations, Complications, and Outcomes. Digestive Diseases and Sciences. 2020; 65:1239-1251.
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