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Member, Division of Oncology
Instructor, UC Department of Pediatrics
melissa.perrino@cchmc.org
513-517-2234
Board Certified
Pediatric hematology/oncology; solid tumor and leukemia/lymphoma
Using a new mouse model to better characterize the progression of plexiform neurofibromas to malignant peripheral nerve sheath tumors in patients/mice with NF1; combining a Mek-inhibitor and CDK4/6 inhibitor for a new therapeutic study in this mouse model; will be studying the immune micro-environment of these tumors and how they change with malignant transformation as well as correlate response to drug therapy
Undergraduate: Ohio State University, Columbus, OH.
MD: Wright State University, Dayton, OH.
Residency: Pediatrics, University of Tennessee Health Science Center, Memphis, TN.
WNT5A inhibition alters the malignant peripheral nerve sheath tumor microenvironment and enhances tumor growth. Thomson, CS; Pundavela, J; Perrino, MR; Coover, RA; Choi, K; Chaney, KE; Rizvi, TA; Largaespada, DA; Ratner, N. Oncogene. 2021; 40:4229-4241.
Genetic predisposition to cancer: Surveillance and intervention. Perrino, M; Cooke-Barber, J; Dasgupta, R; Gener, JI. Seminars in Pediatric Surgery. 2019; 28.