A photo of Cara Slagle.

Cara L. Slagle, MD


  • Attending Neonatologist, Division of Neonatology and Pulmonary Biology
  • Co-Director, Center for Acute Care Nephrology
  • Assistant Professor, UC Department of Pediatrics

About

Biography

Children are the future of our world, and helping neonates and their families through an incredibly challenging time is a privilege and honor. My clinical specialties include neonatology, neonatal acute kidney injury (AKI) and neonatal chronic kidney disease (CKD).

My research areas are focused on the kidneys. AKI is a common occurrence in the neonatal intensive care unit (NICU) secondary to the delicateness of underdeveloped kidneys in preterm infants, the use of medications and the environment required to mimic life outside the uterus to facilitate growth and treat preterm infants. Current research is demonstrating that AKI can have long-term effects and contribute to the development of CKD. Additionally, I am interested in neonatal dialysis and infant survival with fetal end-stage kidney disease.

During my residency, I developed a project to improve the diagnosis of AKI in the NICU and the reporting and referral when indicated to pediatric nephrology. I realized this was an important area that was understudied and underrecognized on a larger scale. Since that study, I joined the Neonatal Kidney Collaborative, which aims to improve the health of newborns with, or at risk for, kidney disease. Here at Cincinnati Children's, our research aims to reduce mortality and morbidity in neonates by improving detection, diagnosis and understanding of risk factors for AKI. In addition to AKI, I conduct research focusing on fetal end-stage kidney disease (ESKD) to improve survival and neonatal and childhood outcomes through an ongoing, multi-disciplinary collaborative quality approach. I am board certified in Pediatrics (2017) by the American Board of Pediatrics.

MD: University of Kentucky, Lexington, KY, 2013.

Residency: Medical University of South Carolina, Charleston, SC, 2016.

Chief Resident: Medical University of South Carolina, Charleston, SC, 2017.

Certification: Pediatrics, 2017.

Interests

Neonatal nephrology

Services and Specialties

Neonatology, Center for Acute Care Nephrology CACN

Interests

AKI, ESRD and progression to CKD

Research Areas

Neonatology

Publications

Selected

Single-Center Experience on Growth in Infants Born With End-Stage Kidney Disease. Slagle, CL; Riddle, SL; McNelis, K; Claes, D. Journal of Renal Nutrition. 2023; 33:236-242.

Selected

Urine Biomarkers for the Assessment of Acute Kidney Injury in Neonates with Hypoxic Ischemic Encephalopathy Receiving Therapeutic Hypothermia. Rumpel, J; Spray, BJ; Chock, VY; Kirkley, MJ; Slagle, CL; Frymoyer, A; Cho, SH; Gist, KM; Blaszak, R; Poindexter, B; Courtney, SE. The Journal of Pediatrics. 2022; 241:133-140.e3.

Selected

Association between Elevated Urine Neutrophil Gelatinase-Associated Lipocalin and Postoperative Acute Kidney Injury in Neonates. Slagle, CL; Goldstein, SL; Gavigan, HW; Rowe, JA; Krallman, KA; Kaplan, HC; Liu, C; Ehrlich, SR; Kotagal, M; Bondoc, AJ; Poindexter, BB. The Journal of Pediatrics. 2021; 238:193-201.e2.

In vitro assessment of the Kirpa Kit™ modified manual single lumen alternating micro-batch (mSLAMB) dialysis device. Ceschia, G; Slagle, CL; Morgan, J; Snyder, A; Rose, JE; Plute, E; Chawla, AK; Coriolan, R; Soranno, DE; Goldstein, SL; Hasson, DC. Pediatric Nephrology. 2024; 39:3543-3549.

Use of urine neutrophil gelatinase-associated lipocalin for nephrotoxic medication acute kidney injury screening in neonates. Slagle, CL; Hemmelgarn, T; Gavigan, HW; Krallman, KA; Goldstein, SL. Journal of Perinatology. 2024; 44:1780-1785.

Characteristics and Outcomes of Children and Young Adults With Sepsis Requiring Continuous Renal Replacement Therapy: A Comparative Analysis From the Worldwide Exploration of Renal Replacement Outcomes Collaborative in Kidney Disease (WE-ROCK). Stanski, NL; Gist, KM; Hasson, D; Stenson, EK; Seo, JD; Ollberding, NJ; Muff-Luett, M; Cortina, G; Alobaidi, R; See, E; Gahring, K; Gales, B; Hilgenkamp, MR; Kanwar, K. Critical Care Medicine. 2024; 52:1686-1699.

Caregiver Awareness and Knowledge of Acute Kidney Injury in Hospitalized Children. Starr, MC; Vanderkolk, J; Goswami, S; Slagle, CL; Soranno, DE. JAMA network open. 2024; 7:e2442442.

The Association Between Vasopressin and Adverse Kidney Outcomes in Children and Young Adults Requiring Vasopressors on Continuous Renal Replacement Therapy. Hasson, DC; Gist, KM; Seo, JD; Stenson, EK; Kessel, A; Haga, T; LaFever, S; Santiago, MJ; Barhight, M; Selewski, D; Dash, A; Ehrlich, JL; Farma, S; Gahring, K. Critical Care Explorations. 2024; 6:e1156.

Continuous Kidney Replacement Therapy and Survival in Children and Young Adults: Findings From the Multinational WE-ROCK Collaborative. Starr, MC; Gist, KM; Zang, H; Ollberding, NJ; Balani, S; Cappoli, A; Ciccia, E; Joseph, C; Kakajiwala, A; Kessel, A; Uber, AM; Van Wyk, B; Zangla, EE; Zappitelli, M. American Journal of Kidney Diseases. 2024; 84:406-415.e1.

Design and Implementation of a Didactic Curriculum in a Large Neonatal-Perinatal Medicine Fellowship Program: A Single-Center Experience. Mukthapuram, S; Ann Johnson, B; Slagle, C; Erickson, J; Kamath-Rayne, BD; Brady, JM. American Journal of Perinatology: neonatal and maternal-fetal medicine. 2024; 41:1874-1879.

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4.6
Overall Patient Rating