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Largest Safety Study on Teen Weight Loss Surgery Finds Few Short-Term Complications

Monday, November 04, 2013

In the largest in-depth scientific study of its kind on the safety of teen weight-loss surgery, researchers report few short-term complications for adolescents with severe obesity undergoing bariatric surgery.

The study, published online today in JAMA Pediatrics, is the first to provide much-needed safety data on bariatric surgery for adolescents with severe obesity, a growing health problem in the U.S. and abroad. The findings represent the largest-ever multicenter, prospective study on the safety of weight loss surgery among adolescents. Led by investigators at Cincinnati Children’s Hospital Medical Center and funded by the National Institutes of Health, research was conducted at five sites around the country.

The study was conducted from 2007 to 2012 and involved 242 participants with an average age of 17 and median body mass index of 50.5. For reference, a 16-year-old girl of average height with a BMI of 50 has a weight of nearly 300 pounds. All participants in the study suffered from health complications resulting from obesity.

Thomas H. Inge, MD, PhD, the study’s principal investigator, and colleagues in Houston, Columbus, Birmingham, Pittsburgh and Cincinnati examined major and minor complications occurring within 30 days of weight loss surgery. Laparoscopic gastric bypass surgery was performed on 66 percent of the study participants, while 28 percent underwent vertical sleeve gastrectomy and another six percent underwent adjustable gastric banding. Information on complications was collected 30 days after surgery.

Initial data from the study suggests weight loss surgery can be offered to adolescents with a reasonable expectation of short-term safety. Seventy-seven percent of study participants showed no post-procedure complications, and an additional 15 percent exhibited only minor complications, such as dehydration. Eight percent of the patients suffered major complications, such as reoperation. There were no deaths.

“This is important news for families considering bariatric surgery for severely obese teens,” said Dr. Inge. “Parents who are considering weight loss surgery for their sons and daughters worry about complications and ask a lot about the safety of surgery – this study should help to alleviate or at least bring those concerns into context.”

Dr. Inge and study colleagues say further research is necessary to accurately gauge long-term risks and benefits for adolescents undergoing weight loss surgery. The Teen Longitudinal Assessment of Bariatric Surgery (Teen-LABS) is currently following these participants to collect this information.

Obesity threatens the health of millions of children and adolescents, particularly the estimated 4–7 percent of youth who are considered severely obese. Over the past decade, approximately 10,000 teenagers have undergone bariatric weight loss surgery.

In addition to investigators from Cincinnati Children’s, the Teen-LABS study included researchers from Texas Children’s Hospital, Nationwide Children’s Hospital, the University of Alabama at Birmingham, the University of Pittsburgh Medical Center, the University of Cincinnati and the National Institute of Diabetes and Digestive and Kidney Diseases.

About Cincinnati Children’s

Cincinnati Children’s Hospital Medical Center ranks third in the nation among all Honor Roll hospitals in U.S.News and World Report’s 2013 Best Children’s Hospitals ranking. It is ranked #1 for cancer and in the top 10 for nine of 10 pediatric specialties. Cincinnati Children’s is one of the top three recipients of pediatric research grants from the National Institutes of Health, and a research and teaching affiliate of the University of Cincinnati College of Medicine. The medical center is internationally recognized for improving child health and transforming delivery of care through fully integrated, globally recognized research, education and innovation. Additional information can be found at www.cincinnatichildrens.org. Connect on the Cincinnati Children’s blog, via Facebook and on Twitter.