Setting New Standard for Urological Care in rPSARP Patients

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Setting New Standard for Urological Care in rPSARP Patients

Identifying risk factors and monitoring function can help guide care and improve quality of life for patients with anorectal malformations.

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Anticipating and Managing Bladder Function Changes

A recent study reveals that repeat anorectal malformation (ARM) surgery can negatively impact bladder function in some patients, highlighting the need for close urologic monitoring.

ARMs frequently involve neurogenic bladder, where nerve issues impact bladder function. While the standard posterior sagittal anorectoplasty (PSARP) surgery for correcting ARMs is thought to minimally affect bladder dynamics, the effects of reoperative PSARP (rPSARP)—repeat surgery for patients requiring further intervention—are not well studied.

Study Overview

Michael Daugherty, MD, MHI, director of the Healthy Bladder Clinic at Cincinnati Children’s, led a study to assess the influence of rPSARP on bladder function. The study reviewed the medical records of patients who underwent rPSARP between 2008 and 2015.

Researchers focused on patients who received urologic follow-up after surgery. Data analysis included factors like the original severity of ARM, coexisting spinal anomalies (if any) and reasons for rPSARP. Additionally, urodynamic variables and bladder management techniques (voiding, intermittent catheterization or urinary diversion) were evaluated before and after rPSARP.

Key Findings

The study involved 172 patients, of which 85 met the inclusion criteria.
Of study subjects, 42% (36 patients) had spinal cord anomalies.
The most common reasons for rPSARP were misplacement of the surgical repair (42 patients), posterior urethral diverticulum (16 patients), stricture (19 patients) and rectal prolapse (8 patients).
Within one year following rPSARP, 13% (11 patients) experienced a negative change in bladder management, requiring them to begin intermittent catheterization or undergo urinary diversion. This number increased to 19% (16 patients) at the final follow-up.
The study suggests that patients who underwent rPSARP for misplacement or stricture were more likely to experience a postoperative decline in bladder function.

Nearly one in five patients experienced a negative change in bladder function after surgery.

Michael Daugherty, MD, MHI

The Importance of Monitoring

The findings of this study highlight the importance of close urologic monitoring for patients undergoing rPSARP. As Daugherty points out, "Nearly one in five patients experienced a negative change in bladder function after surgery."

Daugherty underscores the importance of open communication with families. He recommends discussing potential urologic complications associated with ARM and rPSARP before the procedure.

In addition to preoperative discussions, he recommends a low threshold for consulting a urologist, especially for patients undergoing rPSARP. Ideally, urologic evaluation should be routinely incorporated into the standard of care for ARM patients. This would allow for establishing a baseline assessment of bladder function and monitoring for any changes that might come up after surgery.

Patient Management

Daugherty suggests an approach to managing these patients postoperatively similar to that used for neurogenic bladder patients. Follow-up appointments may be more frequent during the first year after surgery. These intervals then can be gradually extended as long as the patient's condition remains stable without the development of new symptoms like leakage or infections. Regular ultrasounds are also recommended to monitor kidney health.

Future Research Directions

Future research efforts may focus on several key areas, including:

Strengthening understanding of the link between ARM and long-term urologic complications.
Identifying factors that predict post-rPSARP bladder dysfunction risk to develop preoperative risk stratification tools for patient counseling and intervention planning.

Daugherty notes that the aim is to better identify ARM patients at the highest risk of requiring increased bladder management after surgery.

"With a larger cohort, we can better counsel families and risk stratify patients pre- or post-operatively based on who truly needed more bladder intervention,” he says.

Collaboration is Key

A collaborative approach involving urology, colorectal surgery, adolescent gynecology and mental health care providers allows for comprehensive care coordination and streamlined communication with families. This integrated model ensures that ARM patients receive well-rounded care tailored to their specific needs.

Cincinnati Children's Pediatric Urology is at the forefront of providing high-quality, multidisciplinary care for ARM patients.

With our team of specialized experts, advanced research capabilities and family-centered approach, we are well-equipped to address the complex needs of these patients and continue improving treatment outcomes. Learn more about urology at Cincinnati Children’s.

(Published October 2024)