Whitsett Lab
Publications

Publications

Thébaud, B; Goss, KN; Laughon, M; Whitsett, JA; Abman, SH; Steinhorn, RH; Aschner, JL; Davis, PG; Mcgrath-Morrow, SA; Soll, RF; Jobe, AH. Bronchopulmonary dysplasia. Nature Reviews Disease Primers. 2019; 5(1):78.

Ren, X; Ustiyan, V; Guo, M; Wang, G; Bolte, C; Zhang, Y; Xu, Y; Whitsett, JA; Kalin, TV; Kalinichenko, VV. Postnatal Alveologenesis Depends on FOXF1 Signaling in c-KIT+ Endothelial Progenitor Cells. American Journal of Respiratory and Critical Care Medicine. 2019; 200(9):1164-1176.

Pradhan, A; Dunn, A; Ustiyan, V; Bolte, C; Wang, G; Whitsett, JA; Zhang, Y; Porollo, A; Hu, Y-C; Xiao, R; Szafranski, P; Shi, D; Stankiewicz, P; Kalin, TV; Kalinichenko, VV. The S52F FOXF1 Mutation Inhibits STAT3 Signaling and Causes Alveolar Capillary Dysplasia. American Journal of Respiratory and Critical Care Medicine. 2019; 200(8):1045-1056.

Du, Y; Clair, GC; Al Alam, D; Danopoulos, S; Schnell, D; Kitzmiller, JA; Misra, RS; Bhattacharya, S; Warburton, D; Mariani, TJ; Pryhuber, GS; Whitsett, JA; Ansong, C; Xu, Y. Integration of transcriptomic and proteomic data identifies biological functions in cell populations from human infant lung. American Journal of Physiology - Lung Cellular and Molecular Physiology. 2019; 317(3):L347-L360.

Guo, M; Du, Y; Gokey, JJ; Ray, S; Bell, SM; Adam, M; Sudha, P; Perl, AK; Deshmukh, H; Potter, SS; Whitsett, JA; Xu, Y. Single cell RNA analysis identifies cellular heterogeneity and adaptive responses of the lung at birth. Nature Communications. 2019; 10(1):37.

Whitsett, JA; Kalin, TV; Xu, Y; Kalinichenko, VV. Building and Regenerating the Lung Cell by Cell. Physiological Reviews. 2019; 99(1):513-554.

Gokey, JJ; Snowball, J; Sridharan, A; Speth, JP; Black, KE; Hariri, LP; Perl, A-KT; Xu, Y; Whitsett, JA. MEG3 is increased in idiopathic pulmonary fibrosis and regulates epithelial cell differentiation. JCI Insight. 2018; 3(17).

Tang, X; Snowball, JM; Xu, Y; Na, C-L; Weaver, TE; Clair, G; Kyle, JE; Zink, EM; Ansong, C; Wei, W; Huang, M; Lin, X; Whitsett, JA. EMC3 coordinates surfactant protein and lipid homeostasis required for respiration. Journal of Clinical Investigation. 2017; 127(12):4314-4325.

Gray, J; Oehrle, K; Worthen, G; Alenghat, T; Whitsett, J; Deshmukh, H. Intestinal commensal bacteria mediate lung mucosal immunity and promote resistance of newborn mice to infection. Science Translational Medicine. 2017; 9(376).

Whitsett, JA; Morrisey, EE. INFLAMMATION. Modulating pulmonary inflammation. Science. 2016; 351(6274):662-663.

Gomez-Arroyo, J; Houweling, AC; Postma, AV; Ganjawala, T; Dooijes, D; Bogaard, HJ; Aman, J; Zwart, R; Kitzmiller, JA; Edel, GG; Zacharias, WJ; Martin, LJ; Kalinichenko, VV; Nichols, WC. Rare Coding Variants in FOXF1 are Associated with Pulmonary Arterial Hypertension. American Journal of Respiratory and Critical Care Medicine. 2026.

Alharbi, R; Keles, M; Fernandes, N; Maude, H; Fellows, A; Williams, RD; Chen, C-N; Lambie, N; Matthews, N; Al-Sahaf, M; Lawrie, A; Whitsett, JA; Cebola, I; Wojciak-Stothard, B. KLF6 activation marks an angiogenic and apoptosis resistant endothelial phenotype in pulmonary arterial hypertension. Communications Biology. 2026; 9(1).

Bui, S; Reineberg, A; Jones, D; Na, C-L; Kitzmiller, J; Rodriguez, L; Murthy, A; Iyer, S; Cooper, C; Chroneos, R; Kotton, D; Alysandratos, K-D; Whitsett, J; Beers, M. Interstitial lung disease-associated isoforms induce divergent pathways of maturation for Surfactant Protein C biosynthesis. Physiology. 2026; 41(S1):2300986.

Lee, H; Jaquish, A; Fernandes, S; Zhao, B; Elitz, A; Cook, K; Trovillion, S; Bottasso-Arias, N; Han, SJY; Goodwin, S; Sinner, D; Sun, X; Swarr, DT; Zacharias, WJ. Cell fate specification during respiratory development requires ARID1A-containing canonical BAF complex activity. Nature Communications. 2026; 17(1).

Bui, S; Reineberg, A; Jones, D; Na, C-L; Kitzmiller, J; Rodriguez, LR; Murthy, A; Iyer, S; Cooper, C; Chroneos, R; Kotton, DN; Alysandratos, K-D; Whitsett, JA; Beers, MF. Divergent pathways of surfactant protein C maturation for disease-associated isoforms. Journal of Biological Chemistry. 2026; 302(3):111252.

Liu, B; Fink-Baldauf, IM; Stuart, WD; Jiang, C; Naren, AP; Shi, D; Guo, M; Whitsett, JA; Maeda, Y. Lipid Nanoparticle Delivery of iMDK Induces ATF3-Mediated Apoptosis in Sotorasib-Resistant KRAS Mutant Lung Cancer. Molecular Pharmaceutics. 2025; 22(9):5523-5532.

Miao, Y; Pek, NM; Tan, C; Jiang, C; Yu, Z; Iwasawa, K; Shi, M; Kechele, DO; Sundaram, N; Pastrana-Gomez, V; Zorn, AM; Chen, Y-W; Guo, M; Gu, M. Co-development of mesoderm and endoderm enables organotypic vascularization in lung and gut organoids. Cell. 2025; 188(16):4295-4313.e27.

Reese, CN; Reese, J; Whitsett, JA. Mildred T. Stahlman, MD-Neonatal trailblazer lived simple life in Tennessee, devoted to friends, colleagues, and patients. Pediatric Research. 2025; 98(2):747-748.

Kang, MH; Thomas, SP; Westley, C; Blouin, T; Xu, L; Chan, YK; Lisk, E; Allen, SE; Vadivel, A; Nangle, K; Church, GM; Whitsett, JA; Wootton, SK; Thébaud, B. Novel Immune Response Evasion Strategy to Redose Adeno-associated Viral Vectors and Prolong Survival in Surfactant Protein-B-Deficient Mice. American Journal of Respiratory Cell and Molecular Biology. 2025; 73(1):120-134.

Li, Q; Liao, Y; Zeng, J; Hu, S; Li, C; Whitsett, JA; Zheng, Y; Luo, F; Xu, C; He, T; Lin, X; Wan, H. KLF5 Shapes Developing Respiratory Tubules by Inhibiting Actin Asymmetry in Epithelial Cells. American Journal of Respiratory Cell and Molecular Biology. 2025; 72(6):663-677.

Gomez-Arroyo, J; Houweling, A; Bogaard, HJ; Aman, J; Kitzmiller, J; Dooijes, D; Aldred, M; Gräf, S; Rhodes, CJ; Chung, WK; Whitsett, JA; Martin, LJ; Kalinichenko, V; Nichols, WC. Association of FOXF1 Genomic Variants With Children and Adults With Pulmonary Arterial Hypertension. American Journal of Respiratory and Critical Care Medicine. 2025; 211(Supplement_1):a3275-a3275.

Kim, H; Yi, S; Liyanage, P; Zhao, S; Wikenheiser-Brokamp, KA; Mcmillin, L; Xu, Y; Kitzmiller, JA; Whitsett, JA; Naren, AP; Mun, KS. Development of a 3D bioengineered human lung submucosal gland ductal airway model to study mucociliary clearance in vitro. Cell Biomater. 2025; 1(2).

Liu, B; Sajiki, Y; Littlefield, N; Hu, Y; Stuart, WD; Sridharan, A; Cui, X; Siefert, ME; Araki, K; Ziady, AG; Shi, D; Whitsett, JA; Maeda, Y. PBAE-PEG-based lipid nanoparticles for lung cell-specific gene delivery. Molecular Therapy. 2025; 33(3):1154-1165.

Penrod, S; Tang, X; Moon, C; Whitsett, JA; Naren, AP; Huang, Y. EMC3 is critical for CFTR function and calcium mobilization in the mouse intestinal epithelium. American Journal of Physiology - Gastrointestinal and Liver Physiology. 2025; 328(1):G72-G82.

Deshmukh, H; Whitsett, J; Zacharias, W; Way, SS; Martinez, FD; Mizgerd, J; Pryhuber, G; Ambalavanan, N; Bacharier, L; Natarajan, A; Randolph, A; Nino, G; Mejias, A; Ramilo, O. Impact of Viral Lower Respiratory Tract Infection (LRTI) in Early Childhood (0-2 Years) on Lung Growth and Development and Lifelong Trajectories of Pulmonary Health: A National Institutes of Health (NIH) Workshop Summary. Pediatric Pulmonology. 2025; 60(1):e27357.

Whitsett, JA; Sever, Z. Respiratory Epithelial Cell Gene Transcription. In: Lung Growth and Development. Taylor & Francis; 2024:37-54.

Tang, X; Wei, W; Sun, Y; Weaver, TE; Nakayasu, ES; Clair, G; Snowball, JM; Na, C-L; Apsley, KS; Martin, EP; Molkentin, JD; Gower, WA; Lin, X; Whitsett, JA. EMC3 regulates trafficking and pulmonary toxicity of the SFTPCI73T mutation associated with interstitial lung disease. Journal of Clinical Investigation. 2024; 134(23).

He, H; Bell, SM; Davis, AK; Zhao, S; Sridharan, A; Na, C-L; Guo, M; Xu, Y; Snowball, J; Swarr, DT; Zacharias, WJ; Whitsett, JA. PRDM3/16 regulate chromatin accessibility required for NKX2-1 mediated alveolar epithelial differentiation and function. Nature Communications. 2024; 15(1):8112.

Wang, G; Wen, B; Guo, M; Li, E; Zhang, Y; Whitsett, JA; Kalin, TV; Kalinichenko, VV. Identification of endothelial and mesenchymal FOXF1 enhancers involved in alveolar capillary dysplasia. Nature Communications. 2024; 15(1):5233.

Bhattacharya, S; Myers, JA; Baker, C; Guo, M; Danopoulos, S; Myers, JR; Bandyopadhyay, G; Romas, ST; Huyck, HL; Misra, RS; Whitsett, JA; Xu, Y; Pryhuber, GS; Mariani, TJ. Single-Cell Transcriptomic Profiling Identifies Molecular Phenotypes of Newborn Human Lung Cells. Genes. 2024; 15(3).

Gaddis, N; Fortriede, J; Guo, M; Bardes, EE; Kouril, M; Tabar, S; Burns, K; Ardini-Poleske, ME; Loos, S; Schnell, D; Xu, Y; Tickle, T; Aronow, BJ; Salomonis, N. LungMAP Portal Ecosystem: Systems-level Exploration of the Lung. American Journal of Respiratory Cell and Molecular Biology. 2024; 70(2):129-139.

Bzdęga, K; Biela, M; Deutsch, GH; Kitzmiller, JA; Rydzanicz, M; Płoski, R; Whitsett, JA; Śmigiel, R; Karolak, JA. A novel non-recurrent CNV deletion involving TBX4 and leaving TBX2 intact causes congenital alveolar dysplasia. Clinical Genetics. 2024; 105(2):190-195.

Wambach, JA; Wegner, DJ; Kitzmiller, J; White, FV; Heins, HB; Yang, P; Paul, AJ; Granadillo, JL; Eghtesady, P; Kuklinski, C; Schroeder, MC; Neidich, JA; Whitsett, JA; Cole, FS. Homozygous, Intragenic Tandem Duplication of SFTPB Causes Neonatal Respiratory Failure. American Journal of Respiratory Cell and Molecular Biology. 2024; 70(1):78-80.

Swarr, DT; Whitsett, JA. Genetic disorders of alveolar formation and homeostasis. In: Neonatology Questions and Controversies the Newborn Lung. 2024:337-348.

A. Whitsett, J; Que, J. The Journal of Respiratory Biology and Translational Medicine, a Versatile Platform for Basic and Clinical Science. Journal of Respiratory Biology and Translational Medicine. 2024; 1(1):10001-10001.

Huang, Y; Penrod, S; Whitsett, J; Naren, A. 331 Endoplasmic reticulum membrane protein complex is required for CFTR biogenesis and activation in vivo. Journal of Cystic Fibrosis. 2023; 22:s165.

Kim, H; Yi, S; Wikenheiser-Brokamp, K; Whitsett, J; Naren, A; Mun, K. 157 Patient-derived 3-D lung airway model to study mucociliary clearance. Journal of Cystic Fibrosis. 2023; 22:s83.

Guo, M; Wikenheiser-Brokamp, KA; Kitzmiller, JA; Jiang, C; Wang, G; Wang, A; Preissl, S; Hou, X; Buchanan, J; Karolak, JA; Stankiewicz, P; Kalinichenko, VV; Wambach, JA; Whitsett, JA. Single Cell Multiomics Identifies Cells and Genetic Networks Underlying Alveolar Capillary Dysplasia. American Journal of Respiratory and Critical Care Medicine. 2023; 208(6):709-725.

Guo, M; Morley, MP; Jiang, C; Wu, Y; Li, G; Du, Y; Zhao, S; Wagner, A; Cakar, AC; Kouril, M; Sun, X; Morrisey, EE; Whitsett, JA; Xu, Y. Guided construction of single cell reference for human and mouse lung. Nature Communications. 2023; 14(1):4566.

Sikkema, L; Ramírez-Suástegui, C; Strobl, DC; Gillett, TE; Zappia, L; Madissoon, E; Markov, NS; Zaragosi, L-E; Ji, Y; Ansari, M; Misharin, AV; Nawijn, MC; Luecken, MD; Theis, FJ. An integrated cell atlas of the lung in health and disease. Nature Medicine. 2023; 29(6):1563-1577.

Olatoke, T; Wagner, A; Astrinidis, A; Zhang, EY; Guo, M; Zhang, AG; Mattam, U; Kopras, EJ; Gupta, N; Smith, EP; Whitsett, JA; Mccormack, FX; Xu, Y; Yu, JJ. Single-cell multiomic analysis identifies a HOX-PBX gene network regulating the survival of lymphangioleiomyomatosis cells. Science Advances. 2023; 9(19):eadf8549.

Huang, Y; Penrod, S; Whitsett, J; Naren, AP. Su1232 EMC REGULATES INTESTINAL EPITHELIAL STEM CELL HOMEOSTASIS PARTIALLY THROUGH CALCIUM MOBILIZATION. Gastroenterology. 2023; 164(6):s-560.

Karolak, JA; Welch, CL; Mosimann, C; Bzdęga, K; West, JD; Montani, D; Eyries, M; Mullen, MP; Abman, SH; Prapa, M; Galambos, C; Stankiewicz, P; Chung, WK; Austin, ED. Molecular Function and Contribution of TBX4 in Development and Disease. American Journal of Respiratory and Critical Care Medicine. 2023; 207(7):855-864.

Tang, X; Wei, W; Snowball, JM; Nakayasu, ES; Bell, SM; Ansong, C; Lin, X; Whitsett, JA. EMC3 regulates mesenchymal cell survival via control of the mitotic spindle assembly. iScience. 2023; 26(1):105667.

Swarr, DT; Whitsett, JA. Molecular and Cellular Determinants of Lung Morphogenesis. In: Kendig and Wilmott S Disorders of the Respiratory Tract in Children. 2023:2-15.e5.

Huang, Y; Whitsett, J; Naren, A. 667 Endoplasmic reticulum membrane protein complex is required for cystic fibrosis transmembrane conductance regulator biogenesis and activation in vivo. Journal of Cystic Fibrosis. 2022; 21:s364-s365.

Toth, A; Steinmeyer, S; Kannan, P; Gray, J; Jackson, CM; Mukherjee, S; Demmert, M; Sheak, JR; Benson, D; Kitzmiller, J; Chougnet, CA; Jobe, AH; Deshmukh, H; Zacharias, WJ. Inflammatory blockade prevents injury to the developing pulmonary gas exchange surface in preterm primates. Science Translational Medicine. 2022; 14(638):eabl8574.

Clair, G; Bramer, LM; Misra, R; Mcgraw, MD; Bhattacharya, S; Kitzmiller, JA; Feng, S; Danna, VG; Bandyopadhyay, G; Bhotika, H; Whitsett, JA; Pryhuber, GS; Adkins, JN; Ansong, C. Proteomic Analysis of Human Lung Development. American Journal of Respiratory and Critical Care Medicine. 2022; 205(2):208-218.

Sun, X; Perl, A-K; Li, R; Bell, SM; Sajti, E; Kalinichenko, VV; Kalin, TV; Misra, RS; Deshmukh, H; Clair, G; Xu, Y; Pryhuber, G; Whitsett, J; Morrisey, EE. A census of the lung: CellCards from LungMAP. Developmental Cell. 2022; 57(1):112-145.e2.

Kingma, PS; Guiot, N; Whitsett, JA. Pulmonary Collectins☆. In: Encyclopedia of Respiratory Medicine. Elsevier; 2022:595-605.

Trainees
Give Today

3333 Burnet Avenue, Cincinnati, Ohio 45229-3026

© 2026 Cincinnati Children's Hospital Medical Center. All rights reserved.

U.S. News & World Report Honor Roll Badge for Top Children's Hospital.Best Places to Work.America's Best Large Employers