A photo of Mekibib Altaye.

Director, Data Management and Analysis Center

Professor, UC Department of Pediatrics

513-636-5849

513-636-7509

Biography & Affiliation

Biography

Many well-thought-out research studies fail to answer the questions they pose because of a lack of planning for appropriate study design and subsequent analysis.

I’m passionate about providing optimal design and analysis plans for such projects, so that the results of the study clearly answer the questions posed. My research focuses on the design and analysis of correlated data, particularly high-dimensional data obtained from neuroimaging studies such as MRI, functional MRI (fMRI), diffusion tensor imaging (DTI) and magnetic resonance spectroscopy (MRS).

I have been a researcher for more than 22 years and began my work at Cincinnati Children’s in 2001. My research is funded by the National Institutes of Health (NIH), the Centers for Disease Control and Prevention (CDC) and the Department of Defense (DoD).

One of my significant research contributions was the development of the first infant brain template used to make inferences about neuroimaging research (2008). Since then, many researchers have downloaded this template for use in their studies.

In addition to authoring and co-authoring more than 150 peer-reviewed publications and a book chapter, I have presented my work at national meetings.

I’m currently the director of the Data Management and Analysis Center within the Division of Biostatistics and Epidemiology at Cincinnati Children’s. In this role, — where I often work with other biostatisticians, epidemiologists and informaticists — I enjoy helping others, solving problems and making sense of data. My work takes place in a highly collaborative environment; I partner with teams of basic and clinical scientists representing a variety of disciplines that leverage neuroimaging as part of their studies.

Research Interests

Design and analysis of correlated data. This includes developing inference procedures for intraclass correlation, and kappa statistic. Modeling issues associated with high dimensional data that arise from brain imaging studies such as fMRI, MRI and DTI.

Academic Affiliation

Professor, UC Department of Pediatrics

Research Divisions

Biostatistics and Epidemiology

Education

PhD: The University of Western Ontario, London, Canada, 1998.

MSc: Oklahoma State University, Stillwater, OK, 1991.

BSc: Addis Ababa Universtiy, Addis Ababa, Ethiopia, 1983.

Publications

Association of Age of Enrollment in Early Intervention with Emergent Literacy in Children Who Are Deaf or Hard of Hearing. Meinzen-Derr, J; Altaye, M; Grove, W; Folger, AT; Wiley, S. Journal of Developmental and Behavioral Pediatrics. 2021.

Perinatal Risk and Protective Factors in the Development of Diffuse White Matter Abnormality on Term-Equivalent Age Magnetic Resonance Imaging in Infants Born Very Preterm. Parikh, NA; Sharma, P; He, L; Li, H; Altaye, M; Priyanka Illapani, VS; Arnsperger, A; Beiersdorfer, T; Bridgewater, K; Cahill, T; et al. Journal of Pediatrics. 2021; 233:58-65.e3.

A Report on the Use of Telehealth in Otolaryngology: In the Pre COVID-19 Era. Wang, JC; Elson, NC; Epperson, MV; Doarn, CR; Altaye, M; Tabangin, ME; Patil, RD; Patil, YJ. Telemedicine Journal and e-Health. 2021.

White Matter Alteration Following SWAT Explosive Breaching Training and the Moderating Effect of a Neck Collar Device: A DTI and NODDI Study. Yuan, W; Dudley, J; Slutsky-Ganesh, AB; Leach, J; Scheifele, P; Altaye, M; Barber Foss, KD; Diekfuss, JD; Rhea, CK; Myer, GD. Military Medicine. 2021.

Modified Head and Neck Swallow Scale: Using EORTC-QLQ-H&N35 to Predict Overall Survival. von Allmen, D; Tang, A; Takiar, V; Zender, C; Romeo, S; Masch, J; Casper, K; Patil, Y; Wilson, K; Khosla, S; et al. Laryngoscope. 2021.

Effects of intraventricular hemorrhage on white matter microstructural changes at term and early developmental outcomes in infants born very preterm. Yuan, W; Tamm, L; Harpster, K; Altaye, M; Illapani, VS P; Parikh, NA. Neuroradiology. 2021.

Diffusion tensor imaging in children following prenatal myelomeningocele repair and its predictive value for the need and timing of subsequent CSF diversion surgery for hydrocephalus. Yuan, W; Stevenson, CB; Altaye, M; Jones, BV; Leach, J; Lovha, M; Rennert, N; Mangano, FT. Journal of Neurosurgery: Pediatrics. 2021; 1-9.

Flexible multivariate joint model of longitudinal intensity and binary process for medical monitoring of frequently collected data. Gupta, R; Khoury, JC; Altaye, M; Jandarov, R; Szczesniak, RD. Statistics in Medicine. 2021; 40:1845-1858.

Magnetic resonance spectroscopy brain metabolites at term and 3-year neurodevelopmental outcomes in very preterm infants. Illapani, VS P; Edmondson, DA; Cecil, KM; Altaye, M; Kumar, M; Harpster, K; Parikh, NA. Pediatric Research. 2021.

Hypoglossal Nerve Stimulation: Outcomes in Veterans with Obstructive Sleep Apnea and Common Comorbid Post-traumatic Stress Disorder. Dhanda Patil, R; Sarber, KM; Epperson, MV; Tabangin, M; Altaye, M; Mesa, F; Ishman, SL. Laryngoscope. 2021; 131 Suppl 3:S1-S11.