A photo of Mekibib Altaye.

Director, Data Management and Analysis Center

Professor, UC Department of Pediatrics

513-636-5849

513-636-7509

Biography & Affiliation

Biography

Many well-thought-out research studies fail to answer the questions they pose because of a lack of planning for appropriate study design and subsequent analysis.

I’m passionate about providing optimal design and analysis plans for such projects, so that the results of the study clearly answer the questions posed. My research focuses on the design and analysis of correlated data, particularly high-dimensional data obtained from neuroimaging studies such as MRI, functional MRI (fMRI), diffusion tensor imaging (DTI) and magnetic resonance spectroscopy (MRS).

I have been a researcher for more than 22 years and began my work at Cincinnati Children’s in 2001. My research is funded by the National Institutes of Health (NIH), the Centers for Disease Control and Prevention (CDC) and the Department of Defense (DoD).

One of my significant research contributions was the development of the first infant brain template used to make inferences about neuroimaging research (2008). Since then, many researchers have downloaded this template for use in their studies.

In addition to authoring and co-authoring more than 150 peer-reviewed publications and a book chapter, I have presented my work at national meetings.

I’m currently the director of the Data Management and Analysis Center within the Division of Biostatistics and Epidemiology at Cincinnati Children’s. In this role, — where I often work with other biostatisticians, epidemiologists and informaticists — I enjoy helping others, solving problems and making sense of data. My work takes place in a highly collaborative environment; I partner with teams of basic and clinical scientists representing a variety of disciplines that leverage neuroimaging as part of their studies.

Research Interests

Design and analysis of correlated data. This includes developing inference procedures for intraclass correlation, and kappa statistic. Modeling issues associated with high dimensional data that arise from brain imaging studies such as fMRI, MRI and DTI.

Academic Affiliation

Professor, UC Department of Pediatrics

Research Divisions

Biostatistics

Education

PhD: The University of Western Ontario, London, Canada, 1998.

MSc: Oklahoma State University, Stillwater, OK, 1991.

BSc: Addis Ababa Universtiy, Addis Ababa, Ethiopia, 1983.

Publications

Bariatric Surgery is Associated With Reduced Risk of Breast Cancer in Both Premenopausal and Postmenopausal Women. Feigelson, HS; Caan, B; Weinmann, S; Leonard, AC; Powers, JD; Yenumula, PR; Arterburn, DE; Koebnick, C; Altaye, M; Schauer, DP. Annals of Surgery. 2020; 272:1053-1059.

Cerebral microvascular and microstructural integrity is regionally altered in patients with systemic lupus erythematosus. DiFrancesco, MW; Lee, G; Altaye, M; Beebe, DW; Meyers-Eaton, J; Brunner, HI. Arthritis Research and Therapy. 2020; 22.

Novel diffuse white matter abnormality biomarker at term-equivalent age enhances prediction of long-term motor development in very preterm children. Parikh, NA; Harpster, K; He, L; Illapani, VS P; Khalid, FC; Klebanoff, MA; O’Shea, TM; Altaye, M. Scientific Reports. 2020; 10.

Kindergarten readiness in children who are deaf or hard of hearing who received early intervention. Meinzen-Derr, J; Wiley, S; Grove, W; Altaye, M; Gaffney, M; Satterfield-Nash, A; Folger, AT; Peacock, G; Boyle, C. Pediatrics. 2020; 146:e2020010611-e2020010611.

Biclustering of medical monitoring data using a nonparametric hierarchical Bayesian model. Ren, Y; Sivaganesan, S; Altaye, M; Amin, RS; Szczesniak, RD. Stat. 2020; 9.

Cortical and subcortical volume differences between Benign Epilepsy with Centrotemporal Spikes and Childhood Absence Epilepsy. Fujiwara, H; Tenney, J; Kadis, DS; Altaye, M; Spencer, C; Vannest, J. Epilepsy Research. 2020; 166:106407-106407.

Kindergarten Readiness in Children Who Are Deaf or Hard of Hearing Who Received Early Intervention. Meinzen-Derr, J; Wiley, S; Grove, W; Altaye, M; Gaffney, M; Satterfield-Nash, A; Folger, AT; Peacock, G; Boyle, C. Pediatrics. 2020; 146:e20200557-e20200557.

Early Prediction of Cognitive Deficit in Very Preterm Infants Using Brain Structural Connectome With Transfer Learning Enhanced Deep Convolutional Neural Networks. Chen, M; Li, H; Wang, J; Yuan, W; Altaye, M; Parikh, NA; He, L. Frontiers in Neuroscience. 2020; 14.

Early cortical maturation predicts neurodevelopment in very preterm infants. Kline, JE; Illapani, VS P; He, L; Altaye, M; Logan, JW; Parikh, NA. Archives of Disease in Childhood: Fetal and Neonatal Edition. 2020; 105:460-465.

Hypoglossal Nerve Stimulation in Veterans with Obstructive Sleep Apnea. Sarber, KM; Chang, KW; Epperson, MV; Tabangin, ME; Altaye, M; Ishman, SL; Patil, RD. The Laryngoscope. 2020; 130:2275-2280.