Ian Brett, MD

Constitutive activation and oncogenicity are mediated by loss of helical structure at the cytosolic boundary of thrombopoietin receptor mutant dimers. Defour, J-P; Leroy, E; Dass, S; Balligand, T; Levy, G; Brett, IC; Papadopoulos, N; Mouton, C; Genet, L; Pecquet, C; Staerk, J; Smith, SO; Constantinescu, SN. eLife. 2023; 12.

Tryptophan at the transmembrane-cytosolic junction modulates thrombopoietin receptor dimerization and activation. Defour, J-P; Itaya, M; Gryshkova, V; Brett, IC; Pecquet, C; Sato, T; Smith, SO; Constantinescu, SN. Proceedings of the National Academy of Sciences of the United States of America. 2013; 110(7):2540-2545.

Controlling Thrombopoietin Receptor Dimerization, Orientation and Activation Via Tryptophan 515. Defour, J-P; Itaya, M; Gryshkova, V; Brett, I; Pecquet, C; Sato, T; Smith, SO; Constantinescu, SN. Blood. 2012; 120(21):3449.

Synthesis, purification, and characterization of single helix membrane peptides and proteins for NMR spectroscopy. Itaya, M; Brett, IC; Smith, SO. Methods in Molecular Biology. 2012; 831:333-357.

Orientation-specific signalling by thrombopoietin receptor dimers. Staerk, J; Defour, J-P; Pecquet, C; Leroy, E; Antoine-Poirel, H; Brett, I; Itaya, M; Smith, SO; Vainchenker, W; Constantinescu, SN. EMBO Journal. 2011; 30(21):4398-4413.

Mouse Models of Influenza. Brett, IC; Johansson, BE. In: Handbook on Immunosenescence. Springer Nature; 2009:117-130.

Recombinant influenza B virus HA and NA antigens administered in equivalent amounts are immunogenically equivalent and induce equivalent homotypic and broader heterovariant protection in mice than conventional and live influenza vaccines. Johansson, BE; Brett, IC. Human Vaccines. 2008; 4(6):420-424.

Changing perspective on immunization against influenza. Johansson, BE; Brett, IC. Vaccine. 2007; 25(16):3062-3065.

An inactivated subvirion influenza A (H5N1) vaccine. Johansson, BE; Brett, IC. New England Journal of Medicine. 2006; 354(25):2724-2725.

Variation in the divalent cation requirements of influenza A virus N1 neuraminidases. Brett, IC; Johansson, BE. Journal of Biochemistry. 2006; 139(3):439-447.