Dr. Chen earned a PhD in Bioinformatics from the University of Cincinnati. He did postdoctoral research at the University of Cincinnati’s Department of Environmental Health and Cincinnati Children’s Hospital Medical Center's Department of Biomedical Informatics. Dr. Chen has worked as a computational biologist at GlaxoSmithKline, the world's sixth largest pharmaceutical company.
Under the mentorship of Drs. Bruce Aronow and Anil Jegga, Chen created the ToppGene suite of web applications as part of his PhD thesis. As a research scientist at the University of Cincinnati, he proposed a statistical framework to connect transcription factors with diseases and drugs based on ChIP-seq and mRNA expression. Recently he developed GDDP, a novel phenotype-disease matching method for rare genetic diseases. He has built numerous analytical pipelines for large-scale genomic data and was involved in the development of bioinformatics infrastructure and methodology in the NIH-funded LINCS program.
Rare genetic disease; clinical NGS
Phenomics for common and rare diseases; genetics of preterm birth; genomics of pediatric cancers.
Assistant Professor, UC Department of PediatricsUC Department of Biomedical Informatics