Jing Chen, PhD

Biography & Affiliation Education Publications

Assistant Professor, UC Department of PediatricsUC Department of Biomedical Informatics

Biography & Affiliation

Biography

Dr. Chen earned a PhD in Bioinformatics from the University of Cincinnati. He did postdoctoral research at the University of Cincinnati’s Department of Environmental Health and Cincinnati Children’s Hospital Medical Center's Department of Biomedical Informatics. Dr. Chen has worked as a computational biologist at GlaxoSmithKline, the world's sixth largest pharmaceutical company.

Under the mentorship of Drs. Bruce Aronow and Anil Jegga, Chen created the ToppGene suite of web applications as part of his PhD thesis. As a research scientist at the University of Cincinnati, he proposed a statistical framework to connect transcription factors with diseases and drugs based on ChIP-seq and mRNA expression. Recently he developed GDDP, a novel phenotype-disease matching method for rare genetic diseases. He has built numerous analytical pipelines for large-scale genomic data and was involved in the development of bioinformatics infrastructure and methodology in the NIH-funded LINCS program.

Clinical Interests

Rare genetic disease; clinical NGS

Research Interests

Phenomics for common and rare diseases; genetics of preterm birth; genomics of pediatric cancers.

Academic Affiliation

Assistant Professor, UC Department of PediatricsUC Department of Biomedical Informatics

Department

Biomedical Informatics

Education

BS: National University of Singapore, Singapore, 2002.

PhD: University of Cincinnati, Cincinnati, OH, 2008.

Publications

Novel phenotype-disease matching tool for rare genetic diseases. Chen, J; Xu, H; Jegga, A; Zhang, K; White, PS; Zhang, G. Genetics in Medicine. 2019; 88:341-348.

The N-6-Methyladenosine mRNA Methylase METTL3 Controls Cardiac Homeostasis and Hypertrophy. Dorn, LE; Lasman, L; Chen, J; Xu, X; Hund, TJ; Medvedovic, M; Hanna, JH; van Berlo, JH; Accornero, F. Circulation. 2019; 139:533-545.

In utero gene expression in the Slc39 alpha 8(neo/neo) knockdown mouse. Chen, J; Galvez-Peralta, M; Zhang, X; Deng, J; Liu, Z; Nebert, DW. Scientific Reports. 2018; 8.

An Hsp20-FBXO4 Axis Regulates Adipocyte Function through Modulating PPAR gamma Ubiquitination. Peng, J; Li, Y; Wang, X; Deng, S; Holland, J; Yates, E; Chen, J; Gu, H; Essandoh, K; Mu, X; et al. Cell Reports. 2018; 23:3607-3620.

Offspring sex impacts DNA methylation and gene expression in placentae from women with diabetes during pregnancy. Alexander, J; Teague, AM; Chen, J; Aston, CE; Leung, Y; Chernausek, S; Simmons, RA; Pinney, SE. PLoS ONE. 2018; 13:e0190698-e0190698.

Unsupervised gene expression analyses identify IPF-severity correlated signatures, associated genes and biomarkers. Wang, Y; Yella, J; Chen, J; McCormack, FX; Madala, SK; Jegga, AG. BMC Pulmonary Medicine. 2017; 17.

Characterization of HCV NS3 Protease Variants in HCV/ HIV-Coinfected Patients by Ultra-Deep Sequence Analysis: Relationship with Hepatic Fibrosis. Abdel-hameed, EA; Rouster, SD; Zhang, X; Chen, J; Medvedovic, M; Goodman, ZD; Sherman, KE. Journal of Acquired Immune Deficiency Syndromes. 2017; 74:353-358.

Excessive Reversal of Epidermal Growth Factor Receptor and Ephrin Signaling Following Tracheal Occlusion in Rabbit Model of Congenital Diaphragmatic Hernia. Varisco, BM; Sbragia, L; Chen, J; Scorletti, F; Joshi, R; Wong, HR; Lopes-Figueira, R; Oria, M; Peiro, J. Molecular medicine (Cambridge, Mass.). 2016; 22:398-411.

DNA methylome changes by estradiol benzoate and bisphenol A links early-life environmental exposures to prostate cancer risk. Cheong, A; Zhang, X; Cheung, Y; Tang, W; Chen, J; Ye, S; Medvedovic, M; Leung, Y; Prins, GS; Ho, S. Epigenetics : official journal of the DNA Methylation Society. 2016; 11:674-689.

Reprogramming of the Epigenome by MLL1 Links Early-Life Environmental Exposures to Prostate Cancer Risk. Wang, Q; Trevino, LS; Wong, RL Y; Medvedovic, M; Chen, J; Ho, S; Shen, J; Foulds, CE; Coarfa, C; O'Malley, BW; et al. Molecular Endocrinology -Baltimore-. 2016; 30:856-871.