Photo of { Emily M. Eshleman, PhD}

Emily M. Eshleman, PhD

  • Instructor, UC Department of Pediatrics

About

BS: Cedar Crest College, Allentown, PA, 2011,

PhD: University of Colorado School of Medicine, Aurora, CO, 2017,

Interests

Intestinal Epithelium; Tuft cells; Microbiota; Inflammation; Immune Regulation

Research Areas

Publications

Selected

Epithelial regulation of microbiota-immune cell dynamics. Didriksen, BJ; Eshleman, EM; Alenghat, T. Mucosal Immunology. 2024; 17(2):303-313.

Selected

Microbiota-derived butyrate restricts tuft cell differentiation via histone deacetylase 3 to modulate intestinal type 2 immunity. Eshleman, EM; Rice, T; Potter, C; Waddell, A; Hashimoto-Hill, S; Woo, V; Field, S; Engleman, L; Lim, H-W; Schumacher, MA; Frey, MR; Denson, LA; Finkelman, FD; Alenghat, T. Immunity. 2024; 57(2):319-332.e6.

Selected

Intestinal epithelial HDAC3 and MHC class II coordinate microbiota-specific immunity. Eshleman, EM; Shao, T-Y; Woo, V; Rice, T; Engleman, L; Didriksen, BJ; Whitt, J; Haslam, DB; Way, SS; Alenghat, T. Journal of Clinical Investigation. 2023; 133(4).

Microbiota-derived inosine programs protective CD8+ T cell responses against influenza in newborns. Stevens, J; Culberson, E; Kinder, J; Ramiriqui, A; Gray, J; Bonfield, M; Shao, T-Y; Al Gharaibeh, F; Peterson, L; Steinmeyer, S; Sengupta, S; Alenghat, T; Way, SS; Deshmukh, H. Cell. 2025; 188(16):4239-4256.e19.

Microbiota-derived butyrate dampens linaclotide stimulation of the guanylate cyclase C pathway in patient-derived colonoids. Velez Lopez, A; Waddell, A; Antonacci, S; Castillo, D; Santucci, N; Ollberding, NJ; Eshleman, EM; Denson, LA; Alenghat, T. Neurogastroenterology and Motility. 2023; 35(12):e14681.

Cleaving an epithelial path to food tolerance. Eshleman, EM; Alenghat, T. Cell Research. 2023; 33(12):896-897.

Kruppel-like factor 2+ CD4 T cells avert microbiota-induced intestinal inflammation. Shao, T-Y; Jiang, TT; Stevens, J; Russi, AE; Troutman, TD; Bernieh, A; Pham, G; Erickson, JJ; Eshleman, EM; Alenghat, T; Weaver, CT; Haslam, DB; Deshmukh, H; Way, SS. Cell reports. 2023; 42(11):113323.

IEC-intrinsic IL-1R signaling holds dual roles in regulating intestinal homeostasis and inflammation. Overcast, GR; Meibers, HE; Eshleman, EM; Saha, I; Waggoner, L; Patel, KN; Jain, VG; Haslam, DB; Alenghat, T; Vandussen, KL; Pasare, C. Journal of Experimental Medicine (JEM). 2023; 220(6).

Histone Deacetylase Inhibition by Gut Microbe-Generated Short-Chain Fatty Acids Entrains Intestinal Epithelial Circadian Rhythms. Fawad, JA; Luzader, DH; Hanson, GF; Moutinho, TJ; Mckinney, CA; Mitchell, PG; Brown-Steinke, K; Kumar, A; Park, M; Lee, S; Alenghat, T; Hong, CI; Papin, JA; Moore, SR. Gastroenterology. 2022; 163(5):1377-1390.e11.

Intestinal epithelial MHC class II regulation by HDAC3 instructs microbiota-specific CD4+ T cells. Eshleman, EM; Shao, T-Y; Woo, V; Rice, T; Whitt, J; Engleman, L; Way, SS; Alenghat, T. bioRxiv. 2022; 2022.01.01.473735.

From the Blog

Can the Bugs in Our Guts Help Manage Inflammation?
Research Annual Report 2024

Can the Bugs in Our Guts Help Manage Inflammation?

Emily M. Eshleman, PhD, Theresa Alenghat, VMD, PhD1/30/2024

Give Today

3333 Burnet Avenue, Cincinnati, Ohio 45229-3026

© 1999-2025 Cincinnati Children's Hospital Medical Center. All rights reserved.

U.S. News & World Report Honor Roll Badge for Top Children's Hospital.Best Places to Work.America's Best Large Employers