Emily M. Eshleman, PhD

Instructor, UC Department of Pediatrics

emily.eshleman@cchmc.org

About

BS: Cedar Crest College, Allentown, PA, 2011.

PhD: University of Colorado School of Medicine, Aurora, CO, 2017.

Interests

Intestinal Epithelium; Tuft cells; Microbiota; Inflammation; Immune Regulation

Research Areas

Digestive Health

Publications

Selected

Epithelial regulation of microbiota-immune cell dynamics. Didriksen, BJ; Eshleman, EM; Alenghat, T. Mucosal Immunology. 2024; 17:303-313.

Selected

Microbiota-derived butyrate restricts tuft cell differentiation via histone deacetylase 3 to modulate intestinal type 2 immunity. Eshleman, EM; Rice, T; Potter, C; Waddell, A; Hashimoto-Hill, S; Woo, V; Field, S; Engleman, L; Lim, HW; Schumacher, MA; Frey, MR; Denson, LA; Finkelman, FD; Alenghat, T. Immunity. 2024; 57:319-332.e6.

Selected

Intestinal epithelial HDAC3 and MHC class II coordinate microbiota-specific immunity. Eshleman, EM; Shao, TY; Woo, V; Rice, T; Engleman, L; Didriksen, BJ; Whitt, J; Haslam, DB; Way, SS; Alenghat, T. The Journal of Clinical Investigation. 2023; 133:e162190.

Microbiota-derived inosine programs protective CD8+ T cell responses against influenza in newborns. Stevens, J; Culberson, E; Kinder, J; Ramiriqui, A; Gray, J; Bonfield, M; Shao, TY; Al Gharaibeh, F; Peterson, L; Steinmeyer, S; Sengupta, S; Alenghat, T; Way, SS; Deshmukh, H. Cell. 2025; 188:4239-4256.e19.

Microbiota-derived butyrate dampens linaclotide stimulation of the guanylate cyclase C pathway in patient-derived colonoids. Velez Lopez, A; Waddell, A; Antonacci, S; Castillo, D; Santucci, N; Ollberding, NJ; Eshleman, EM; Denson, LA; Alenghat, T. Neurogastroenterology and Motility. 2023; 35:e14681.

Cleaving an epithelial path to food tolerance. Eshleman, EM; Alenghat, T. Cell Research. 2023; 33:896-897.

Kruppel-like factor 2+ CD4 T cells avert microbiota-induced intestinal inflammation. Shao, TY; Jiang, TT; Stevens, J; Russi, AE; Troutman, TD; Bernieh, A; Pham, G; Erickson, JJ; Eshleman, EM; Alenghat, T; Weaver, CT; Haslam, DB; Deshmukh, H; Way, SS. Cell Reports. 2023; 42:113323.

IEC-intrinsic IL-1R signaling holds dual roles in regulating intestinal homeostasis and inflammation. Overcast, GR; Meibers, HE; Eshleman, EM; Saha, I; Waggoner, L; Patel, KN; Jain, VG; Haslam, DB; Alenghat, T; Vandussen, KL; Pasare, C. The Journal of Experimental Medicine. 2023; 220:e20212523.

Histone Deacetylase Inhibition by Gut Microbe-Generated Short-Chain Fatty Acids Entrains Intestinal Epithelial Circadian Rhythms. Fawad, JA; Luzader, DH; Hanson, GF; Moutinho, TJ; McKinney, CA; Mitchell, PG; Brown-Steinke, K; Kumar, A; Park, M; Lee, S; Alenghat, T; Hong, CI; Papin, JA; Moore, SR. Gastroenterology. 2022; 163:1377-1390.e11.

Commensal segmented filamentous bacteria-derived retinoic acid primes host defense to intestinal infection. Woo, V; Eshleman, EM; Hashimoto-Hill, S; Whitt, J; Wu, SE; Engleman, L; Rice, T; Karns, R; Qualls, JE; Haslam, DB; Vallance, BA; Alenghat, T. Cell Host and Microbe. 2021; 29:1744-1756.e5.