Photo of { Emily M. Eshleman, PhD}

Emily M. Eshleman, PhD

  • Instructor, UC Department of Pediatrics

About

BS: Cedar Crest College, Allentown, PA, 2011,

PhD: University of Colorado School of Medicine, Aurora, CO, 2017,

Interests

Intestinal Epithelium; Tuft cells; Microbiota; Inflammation; Immune Regulation

Research Areas

Publications

Selected

Epithelial regulation of microbiota-immune cell dynamics. Didriksen, BJ; Eshleman, EM; Alenghat, T. Mucosal Immunology. 2024; 17(2):303-313.

Selected

Microbiota-derived butyrate restricts tuft cell differentiation via histone deacetylase 3 to modulate intestinal type 2 immunity. Eshleman, EM; Rice, T; Potter, C; Waddell, A; Hashimoto-Hill, S; Woo, V; Field, S; Engleman, L; Lim, H-W; Schumacher, MA; Frey, MR; Denson, LA; Finkelman, FD; Alenghat, T. Immunity. 2024; 57(2):319-332.e6.

Selected

Intestinal epithelial HDAC3 and MHC class II coordinate microbiota-specific immunity. Eshleman, EM; Shao, T-Y; Woo, V; Rice, T; Engleman, L; Didriksen, BJ; Whitt, J; Haslam, DB; Way, SS; Alenghat, T. Journal of Clinical Investigation. 2023; 133(4).

Microbiota-derived inosine programs protective CD8+ T cell responses against influenza in newborns. Stevens, J; Culberson, E; Kinder, J; Ramiriqui, A; Gray, J; Bonfield, M; Shao, T-Y; Al Gharaibeh, F; Peterson, L; Steinmeyer, S; Sengupta, S; Alenghat, T; Way, SS; Deshmukh, H. Cell. 2025; 188(16):4239-4256.e19.

Microbiota-derived butyrate dampens linaclotide stimulation of the guanylate cyclase C pathway in patient-derived colonoids. Velez Lopez, A; Waddell, A; Antonacci, S; Castillo, D; Santucci, N; Ollberding, NJ; Eshleman, EM; Denson, LA; Alenghat, T. Neurogastroenterology and Motility. 2023; 35(12):e14681.

Cleaving an epithelial path to food tolerance. Eshleman, EM; Alenghat, T. Cell Research. 2023; 33(12):896-897.

Kruppel-like factor 2+ CD4 T cells avert microbiota-induced intestinal inflammation. Shao, T-Y; Jiang, TT; Stevens, J; Russi, AE; Troutman, TD; Bernieh, A; Pham, G; Erickson, JJ; Eshleman, EM; Alenghat, T; Weaver, CT; Haslam, DB; Deshmukh, H; Way, SS. Cell reports. 2023; 42(11):113323.

IEC-intrinsic IL-1R signaling holds dual roles in regulating intestinal homeostasis and inflammation. Overcast, GR; Meibers, HE; Eshleman, EM; Saha, I; Waggoner, L; Patel, KN; Jain, VG; Haslam, DB; Alenghat, T; Vandussen, KL; Pasare, C. Journal of Experimental Medicine (JEM). 2023; 220(6).

Histone Deacetylase Inhibition by Gut Microbe-Generated Short-Chain Fatty Acids Entrains Intestinal Epithelial Circadian Rhythms. Fawad, JA; Luzader, DH; Hanson, GF; Moutinho, TJ; Mckinney, CA; Mitchell, PG; Brown-Steinke, K; Kumar, A; Park, M; Lee, S; Alenghat, T; Hong, CI; Papin, JA; Moore, SR. Gastroenterology. 2022; 163(5):1377-1390.e11.

Intestinal epithelial MHC class II regulation by HDAC3 instructs microbiota-specific CD4+ T cells. Eshleman, EM; Shao, T-Y; Woo, V; Rice, T; Whitt, J; Engleman, L; Way, SS; Alenghat, T. bioRxiv. 2022; 2022.01.01.473735.

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