A photo of James D. Gulick.

Instructor, UC Department of Pediatrics



About Me

Research Interests

Understanding how certain mutations in contractile protein genes are able to alter the function of the heart

Academic Affiliation

Instructor, UC Department of Pediatrics

Clinical Divisions

Heart Institute

My Education

MS: University of Missouri-Columbia, Columbia, Mo, 1983

My Publications

Ube2v1 positively regulates protein aggregation by modulating ubiquitin proteasome system performance partially through K63 ubiquitination. Xu, N; Gulick, J; Osinska, H; Yu, Y; McLendon, PM; Shay-Winkler, K; Robbins, J; Yutzey, KE. Circulation Research. 2020; 126:907-922.

Myofibroblast-Specific TGF beta Receptor II Signaling in the Fibrotic Response to Cardiac Myosin Binding Protein C-Induced Cardiomyopathy. Meng, Q; Bhandary, B; Bhuiyan, MS; James, J; Osinska, H; Valiente-Alandi, I; Shay-Winkler, K; Gulick, J; Molkentin, JD; Blaxall, BC; et al. Circulation Research. 2018; 123:1285-1297.

Hypertrophic cardiomyopathy R403Q mutation in rabbit beta-myosin reduces contractile function at the molecular and myofibrillar levels. Lowey, S; Bretton, V; Joel, PB; Trybus, KM; Gulick, J; Robbins, J; Kalganov, A; Cornachione, AS; Rassier, DE. Proceedings of the National Academy of Sciences of USA. 2018; 115:11238-11243.

Cardiac Fibrosis in Proteotoxic Cardiac Disease is Dependent Upon Myofibroblast TGF-beta Signaling. Bhandary, B; Meng, Q; James, J; Osinska, H; Gulick, J; Valiente-Alandi, I; Sargent, MA; Bhuiyan, S; Blaxall, BC; Molkentin, JD; et al. Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease. 2018; 7.

MMI-0100 Inhibits Cardiac Fibrosis in a Mouse Model Overexpressing Cardiac Myosin Binding Protein C. Meng, Q; Bhandary, B; Osinska, H; James, J; Xu, N; Shay-Winkler, K; Gulick, J; Willis, MS; Lander, C; Robbins, J. Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease. 2017; 6.

An Unbiased High-Throughput Screen to Identify Novel Effectors That Impact on Cardiomyocyte Aggregate Levels. McLendon, PM; Davis, G; Gulick, J; Singh, SR; Xu, N; Salomonis, N; Molkentin, JD; Robbins, J. Circulation Research. 2017; 121:604-616.

In vivo definition of cardiac myosin-binding protein C's critical interactions with myosin. Bhuiyan, MS; McLendon, P; James, J; Osinska, H; Gulick, J; Bhandary, B; Lorenz, JN; Robbins, J. Pflügers Archiv European Journal of Physiology. 2016; 468:1685-1695.

UBC9-Mediated Sumoylation Favorably Impacts Cardiac Function in Compromised Hearts. Gupta, MK; McLendon, PM; Gulick, J; James, J; Khalili, K; Robbins, J. Circulation Research. 2016; 118:1894-1905.

Phosphorylation and calcium antagonistically tune myosin-binding protein C's structure and function. Previs, MJ; Mun, JY; Michalek, AJ; Previs, SB; Gulick, J; Robbins, J; Warshaw, DM; Craig, R. Proceedings of the National Academy of Sciences of USA. 2016; 113:3239-3244.