Myofibroblast-Specific TGF beta Receptor II Signaling in the Fibrotic Response to Cardiac Myosin Binding Protein C-Induced Cardiomyopathy.
Meng, Q; Bhandary, B; Bhuiyan, MS; James, J; Osinska, H; Valiente-Alandi, I; Shay-Winkler, K; Gulick, J; Molkentin, JD; Blaxall, BC; et al.
Circulation Research.
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Hypertrophic cardiomyopathy R403Q mutation in rabbit beta-myosin reduces contractile function at the molecular and myofibrillar levels.
Lowey, S; Bretton, V; Joel, PB; Trybus, KM; Gulick, J; Robbins, J; Kalganov, A; Cornachione, AS; Rassier, DE.
Proceedings of the National Academy of Sciences of USA.
2018;
115:11238-11243.
Cardiac Fibrosis in Proteotoxic Cardiac Disease is Dependent Upon Myofibroblast TGF-beta Signaling.
Bhandary, B; Meng, Q; James, J; Osinska, H; Gulick, J; Valiente-Alandi, I; Sargent, MA; Bhuiyan, S; Blaxall, BC; Molkentin, JD; et al.
Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease.
2018;
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MMI-0100 Inhibits Cardiac Fibrosis in a Mouse Model Overexpressing Cardiac Myosin Binding Protein C.
Meng, Q; Bhandary, B; Osinska, H; James, J; Xu, N; Shay-Winkler, K; Gulick, J; Willis, MS; Lander, C; Robbins, J.
Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease.
2017;
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An Unbiased High-Throughput Screen to Identify Novel Effectors That Impact on Cardiomyocyte Aggregate Levels.
McLendon, PM; Davis, G; Gulick, J; Singh, SR; Xu, N; Salomonis, N; Molkentin, JD; Robbins, J.
Circulation Research.
2017;
121:604-616.
In vivo definition of cardiac myosin-binding protein C's critical interactions with myosin.
Bhuiyan, MS; McLendon, P; James, J; Osinska, H; Gulick, J; Bhandary, B; Lorenz, JN; Robbins, J.
Pflügers Archiv European Journal of Physiology.
2016;
468:1685-1695.
UBC9-Mediated Sumoylation Favorably Impacts Cardiac Function in Compromised Hearts.
Gupta, MK; McLendon, PM; Gulick, J; James, J; Khalili, K; Robbins, J.
Circulation Research.
2016;
118:1894-1905.
Phosphorylation and calcium antagonistically tune myosin-binding protein C's structure and function.
Previs, MJ; Mun, JY; Michalek, AJ; Previs, SB; Gulick, J; Robbins, J; Warshaw, DM; Craig, R.
Proceedings of the National Academy of Sciences of USA.
2016;
113:3239-3244.