A photo of James D. Gulick.

Instructor, UC Department of Pediatrics

513-803-0994

513-636-5958

About Me

Research Interests

Understanding how certain mutations in contractile protein genes are able to alter the function of the heart

Academic Affiliation

Instructor, UC Department of Pediatrics

Clinical Divisions

Heart Institute

My Education

MS: University of Missouri-Columbia, Columbia, Mo, 1983

My Publications

Ube2v1 Positively Regulates Protein Aggregation by Modulating Ubiquitin Proteasome System Performance Partially Through K63 Ubiquitination. Xu, N; Gulick, J; Osinska, H; Yu, Y; McLendon, PM; Shay-Winkler, K; Robbins, J; Yutzey, KE. Circulation Research. 2020; 126:907-922.

Myofibroblast-Specific TGFβ Receptor II Signaling in the Fibrotic Response to Cardiac Myosin Binding Protein C-Induced Cardiomyopathy. Meng, Q; Bhandary, B; Bhuiyan, MS; James, J; Osinska, H; Valiente-Alandi, I; Shay-Winkler, K; Gulick, J; Molkentin, JD; Blaxall, BC; et al. Circulation Research. 2018; 123:1285-1297.

Hypertrophic cardiomyopathy R403Q mutation in rabbit β-myosin reduces contractile function at the molecular and myofibrillar levels. Lowey, S; Bretton, V; Joel, PB; Trybus, KM; Gulick, J; Robbins, J; Kalganov, A; Cornachione, AS; Rassier, DE. Proceedings of the National Academy of Sciences of the United States of America. 2018; 115:11238-11243.

Cardiac Fibrosis in Proteotoxic Cardiac Disease is Dependent Upon Myofibroblast TGF -β Signaling. Bhandary, B; Meng, Q; James, J; Osinska, H; Gulick, J; Valiente-Alandi, I; Sargent, MA; Bhuiyan, S; Blaxall, BC; Molkentin, JD; et al. Journal of the American Heart Association. 2018; 7.

Abstract 265: TGF Beta Signaling and Fibrosis in cMyBP-C-dependent Cardiac Disease. Meng, Q; Bhandary, B; Osinska, H; James, J; Shay-Winkler, K; Gulick, J; McNamara, J; Bhuiyan, MS; Sadayappan, S; Robbins, J. Circulation Research. 2018; 123.

Abstract 238: Ube2v1 Promotes Mutant αB-crystallin-induced Protein Aggregation. Xu, N; McLendon, P; Gulick, J; Osinska, H; Robbins, J. Circulation Research. 2018; 123.

MMI-0100 Inhibits Cardiac Fibrosis in a Mouse Model Overexpressing Cardiac Myosin Binding Protein C. Meng, Q; Bhandary, B; Osinska, H; James, J; Xu, N; Shay-Winkler, K; Gulick, J; Willis, MS; Lander, C; Robbins, J. Journal of the American Heart Association. 2017; 6.

An Unbiased High-Throughput Screen to Identify Novel Effectors That Impact on Cardiomyocyte Aggregate Levels. McLendon, PM; Davis, G; Gulick, J; Singh, SR; Xu, N; Salomonis, N; Molkentin, JD; Robbins, J. Circulation Research. 2017; 121:604-616.