Nandan Gokhale, PhD

Member, Division of Immunobiology
Assistant Professor, UC Department of Pediatrics

nandan.gokhale@cchmc.org

About

Biography

I am an immunologist and researcher interested in immune signaling, virology, ribonucleic acid (RNA) biology and RNA protein interactions. I have been a researcher for over 15 years and started my lab at Cincinnati Children’s in 2025.

The Gokhale lab explores the intricate relationship between RNA, viruses and the immune system during viral infections. Our research aims to uncover how RNA molecules influence and are influenced by viral pathogens and how RNA plays a role in the body's innate immune response. Our lab seeks to provide insights into how viruses manipulate host cells and how the immune system can counteract these infections.

Interests

Innate immune signaling; RNA biology; virology.

Research Areas

Immunobiology

Publications

Interleukin-2-mediated NF-κB-dependent mRNA splicing modulates interferon gamma protein production. Van Gelder, RD; Gokhale, NS; Genoyer, E; Omelia, DS; Anderson, SK; Young, HA; Savan, R. EMBO Reports. 2025; 26:16-35.

Cellular RNA interacts with MAVS to promote antiviral signaling. Gokhale, NS; Sam, RK; Somfleth, K; Thompson, MG; Marciniak, DM; Smith, JR; Genoyer, E; Eggenberger, J; Chu, LH; Park, M; Horner, SM; Ong, SE; Gale, M; Savan, R. Science. 2024; 386:eadl0429.

Host-specific sensing of coronaviruses and picornaviruses by the CARD8 inflammasome. Tsu, BV; Agarwal, R; Gokhale, NS; Kulsuptrakul, J; Ryan, AP; Fay, EJ; Castro, LK; Beierschmitt, C; Yap, C; Turcotte, EA; Hyde, JL; Savan, R; Mitchell, PS; Daugherty, MD. PLoS Biology. 2023; 21:e3002144.

Structure-first identification of RNA elements that regulate dengue virus genome architecture and replication. Boerneke, MA; Gokhale, NS; Horner, SM; Weeks, KM. Proceedings of the National Academy of Sciences of USA. 2023; 120:e2217053120.

ADAR1 mutation causes ZBP1-dependent immunopathology. Hubbard, NW; Ames, JM; Maurano, M; Chu, LH; Somfleth, KY; Gokhale, NS; Werner, M; Snyder, JM; Lichauco, K; Savan, R; Stetson, DB; Oberst, A. Nature. 2022; 607:769-775.

FTO Suppresses STAT3 Activation and Modulates Proinflammatory Interferon-Stimulated Gene Expression. McFadden, MJ; Sacco, MT; Murphy, KA; Park, M; Gokhale, NS; Somfleth, KY; Horner, SM. Journal of Molecular Biology. 2022; 434:167247.

RNA regulatory mechanisms that control antiviral innate immunity. Gokhale, NS; Smith, JR; Van Gelder, RD; Savan, R. Immunological Reviews. 2021; 304:77-96.

Endomembrane targeting of human OAS1 p46 augments antiviral activity. Soveg, FW; Schwerk, J; Gokhale, NS; Cerosaletti, K; Smith, JR; Pairo-Castineira, E; Kell, AM; Forero, A; Zaver, SA; Esser-Nobis, K; Baillie, JK; Buckner, JH; Gale, M; Savan, R. eLife. 2021; 10:e71047.

The m6A reader IMP2 directs autoimmune inflammation through an IL-17- and TNFα-dependent C/EBP transcription factor axis. Bechara, R; Amatya, N; Bailey, RD; Li, Y; Aggor, FE Y; Li, DD; Jawale, CV; Coleman, BM; Dai, N; Gokhale, NS; Poholek, AC; Bansal, A; Biswas, PS; Gaffen, SL. Science immunology. 2021; 6:eabd1287.

Post-transcriptional regulation of antiviral gene expression by N6-methyladenosine. McFadden, MJ; McIntyre, AB R; Mourelatos, H; Abell, NS; Gokhale, NS; Ipas, H; Xhemalçe, B; Mason, CE; Horner, SM. Cell Reports. 2021; 34:108798.