James Heubi, MD, is associate dean for clinical and translational research and professor of pediatrics at the University of Cincinnati College of Medicine. He is the director of the Center for Clinical and Translational Science and Training which is the vehicle by which the University of Cincinnati, Cincinnati Children’s Hospital Medical Center and the Veterans Administration Medical Center administer the NIH-funded, Clinical Translational Science Award and director of the Division of Gastroenterology, Hepatology and Nutrition at the Cincinnati Children’s Hospital Medical Center.

He has been an active clinical investigator with over 195 peer reviewed publications and was the long term program director for the NIH funded General Clinical Research Center. He is the principal investigator and co-investigator on NIH grants and participates is a local principal or co-investigator on two rare disease networks supported by the NIH.

His research interests include cholestatic liver disease in childhood and its complications, inborn errors of bile acid metabolism, bone disease in gastrointestinal and hepatobiliary disorders, fat absorption, and cholesterol absorption and metabolism.

Education and Training

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MD: Indiana University School of Medicine, Indianapolis, IN, 1973.

Residency: James Whitcomb Riley Hospital for Children, Indiana University, Indianapolis, IN, 1973 to 1975.

Fellowship: Pediatric Gastroenterology, Children's Hospital Medical Center, Cincinnati, OH, 1979.

Certification: Pediatric Gastroenterology and Nutrition, 1990.

Publications

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View PubMed Publications

Heubi JE, Setchell KDR, Jha P, Buckley D, Zhang W, Rosenthal P, Potter C, Horslen S, Suskind D. Treatment of bile acid amidation defects with glycocholic acid. Hepatology. 2015 Jan;61(1):268-274.

Setchell KDR, Heubi JE, Shah S, Lavine JE, Suskind D, Al-Edreesi M, Potter C, Russell DW, O’Connell NC, Wolfe B, Jha P, Zhang W, Bove KE, Knisely AS, Hofmann AF, Rosenthal P, Bull LN. Genetic defects in bile acid conjugation cause fat-soluble vitamin deficiency. Gastroenterology. 2013 May;144(5):945-955.

Gonzales E, Gerhardt MF, Fabre M, Setchell KDR, Davit-Spraul A, Vincent I, Heubi JE, Bernard O, Jacquemin E. Oral cholic acid for hereditary defects of primary bile acid synthesis: a safe and effective long-term therapy. Gastroenterology. 2009 Oct;137(4):1310-1320.

Setchell KDR, Heubi JE, Bove KE, O’Connell NC, Brewsaugh T, Steinberg SJ, Moser A, Squires Jr RH. Liver disease caused by failure to racemize trihydroxycholestanocic acid: gene mutation and effect of bile acid therapy. Gastroenterology. 2003 Jan;124(1):217-232.

Oelkers P, Kirby LC, Heubi JE, Dawson PA. Primary bile acid malabsorption caused by mutations in the ileal sodi¬um-de¬pen¬dent bile acid transporter gene (SLC10A2). J Clin Invest. 1997 Apr 15;99(8):1880-1887.

Heubi JE, Hollis BW, Specker B, Tsang RC. Bone disease in chronic childhood cholestasis I. Vitamin D absorption and metabolism. Hepatology. 1989 Feb;9(2):258-264.

Setchell KDR, Suchy FJ, Welsh MB, Zimmer-Nechemias L, Heubi JE, Balistreri WF. Δ4-3-Oxosteroid 5B-reductase deficiency described in identical twins with neonatal hepatitis - A new inborn error in bile acid synthesis. J Clin Invest. 1988 Dec; 82(6):2148-2157.

Heubi JE, Daugherty CC, Partin JS, Partin JC, Schubert WK. Grade l Reye's Syndrome--outcome and predictors of progression to deeper coma grades. N Engl J Med. 1984 Dec 13;311(24):l539-1554.

Lichtenstein PK, Heubi JE, Daugherty CC, Farrell MK, Sokol RJ, Rothbaum RJ, Suchy FJ, Balistreri WF. Grade l Reye's Syndrome. A frequent cause of vomiting and liver dysfunction following varicella and upper respiratory tract infection. N Engl J Med. 1983 Jul;309(3):l33-139.

Heubi JE, Balistreri WF, Fondacaro JD, Partin JC, Schubert WK. Primary bile acid malabsorption: Defective in vitro ileal active bile acid transport. Gastroenterology. 1982 Oct;83(4):804-8ll.

Grants

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Cincinnati Center for Clinical and Translational Science and Training. Principal Investigator. National Center for Advancing Translational Sciences/National Institutes of Health. Aug 2015-Mar 2019. UL1 TR000077-05.

Pediatric Gastroenterology and Nutrition Training Grant. Mentor. National Institute of Diabetes and Digestive and Kidney Diseases/ National Institutes of Health. Jul 2005-Jun 2020. T32 DK007727.

Clinical Center of Cholestatic Liver Disease in Children (CHILDREN). Co-Investigator. National Institute of Diabetes and Digestive and Kidney Diseases/ National Institutes of Health. Sep 2009-May 2019. U01 DK062497.

Sterol and Isoprenoid Diseases Consortium. Site Principal Investigator. Eunice Kennedy Shriver National Institute of Child Health and Human Development/National Institutes of Health. Sep 2009-Jul 2019. U54 HD061939.

Bone Mineral Accretion in Young Children. Co-Investigator. Eunice Kennedy Shriver National Institute of Child Health and Human Development/National Institutes of Health. Sep 2013-Jul 2018. R01 HD076321.

Short Term Medical Student Training Grant. Principal Investigator. National Institute of Diabetes and Digestive and Kidney Diseases/National Institutes of Health. Apr 2002-Mar 2019. T35 DK060444-11.

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