A photo of James Heubi.

Director, Center for Clinical and Translational Science and Training

Associate Dean, Clinical and Translational Research

Professor, UC Department of Pediatrics



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My Biography & Research


James Heubi, MD, is associate dean for clinical and translational research and professor of pediatrics at the University of Cincinnati College of Medicine. He is the director of the Center for Clinical and Translational Science and Training which is the vehicle by which the University of Cincinnati, Cincinnati Children’s Hospital Medical Center and the Veterans Administration Medical Center administer the NIH-funded, Clinical Translational Science Award and director of the Division of Gastroenterology, Hepatology and Nutrition at the Cincinnati Children’s Hospital Medical Center.

He has been an active clinical investigator with over 195 peer reviewed publications and was the long term program director for the NIH funded General Clinical Research Center. He is the principal investigator and co-investigator on NIH grants and participates is a local principal or co-investigator on two rare disease networks supported by the NIH.

His research interests include cholestatic liver disease in childhood and its complications, inborn errors of bile acid metabolism, bone disease in gastrointestinal and hepatobiliary disorders, fat absorption, and cholesterol absorption and metabolism.

Clinical Interests

Pediatric gastroenterology; hepatology and nutrition; pediatric cholestatic liver disease

Research Interests

Pediatric cholestatic liver disease; childhood bone disease; fat malabsorption

Academic Affiliation

Professor, UC Department of Pediatrics

Clinical Divisions

Gastroenterology GI, Liver Care, Liver Transplant

Research Divisions

Gastroenterology Hepatology and Nutrition

Blog Posts

The Surprising Occurrence of Acetaminophen Overdose

BlogSafety and Prevention

The Surprising Occurrence of Acetaminophen Overdose

By James Heubi, MD1/30/2014

My Locations

My Education

MD: Indiana University School of Medicine, Indianapolis, IN, 1973.

Residency: James Whitcomb Riley Hospital for Children, Indiana University, Indianapolis, IN, 1973 to 1975.

Fellowship: Pediatric Gastroenterology, Children's Hospital Medical Center, Cincinnati, OH, 1979.

Certification: Pediatric Gastroenterology and Nutrition, 1990.

My Publications

Longitudinal Outcomes in Young Patients with Alpha-1-Antitrypsin Deficiency with Native Liver Reveal that Neonatal Cholestasis is a Poor Predictor of Future Portal Hypertension. Rosenthal, P; Hawthorne, K; Spino, C; Bass, LM; Murray, KF; Kerkar, N; Magee, JC; Karpen, S; Heubi, JE; Molleston, JP; et al. Journal of Pediatrics. 2020; 227:81-86.e4.

Who's at Risk? A Prognostic Model for Severity Prediction in Pediatric Acute Pancreatitis. Farrell, PR; Hornung, L; Farmer, P; DesPain, AW; Kim, E; Pearman, R; Neway, B; Serrette, A; Sehgal, S; Heubi, JE; et al. Journal of Pediatric Gastroenterology and Nutrition. 2020; 71:536-542.

Implementing a Process to Systematically Identify and Address Poor Medication Adherence in Pediatric Liver Transplant Recipients. Wadhwani, SI; Nichols, M; Klosterkemper, J; Cirincione, R; Whitesell, K; Owen, D; Rengering, R; Walz, B; Heubi, J; Hooper, DK. Pediatric Quality and Safety. 2020; 5.

Open-label Phase 3 Continuation Study of Cholic Acid in Patients With Inborn Errors of Bile Acid Synthesis. Heubi, JE; Setchell, KD R. Journal of Pediatric Gastroenterology and Nutrition. 2020; 70:423-429.

Outcomes of Childhood Cholestasis in Alagille Syndrome: Results of a Multicenter Observational Study. Kamath, BM; Ye, W; Goodrich, NP; Loomes, KM; Romero, R; Heubi, JE; Leung, DH; Spinner, NB; Piccoli, DA; Alonso, EM; et al. Hepatology Communications. 2020; 4:387-398.

Serum Unconjugated Bile Acids and Small Bowel Bacterial Overgrowth in Pediatric Intestinal Failure: A Pilot Study. Galloway, D; Mezoff, E; Zhang, W; Byrd, M; Cole, C; Aban, I; Kocoshis, S; Setchell, KD R; Heubi, JE. Journal of Parenteral and Enteral Nutrition. 2019; 43:263-270.

Bile Acid Synthesis Disorder Masquerading as Intractable Vitamin D-Deficiency Rickets. Ahmad, O; Nogueira, J; Heubi, JE; Setchell, KD R; Ashraf, AP. Journal of the Endocrine Society. 2019; 3:397-402.

Bone Density in Children With Chronic Liver Disease Correlates With Growth and Cholestasis. Loomes, KM; Spino, C; Goodrich, NP; Hangartner, TN; Marker, AE; Heubi, JE; Kamath, BM; Shneider, BL; Rosenthal, P; Hertel, PM; et al. Hepatology. 2019; 69:245-257.

Long-Term Cholic Acid Treatment in a Patient with Zellweger Spectrum Disorder. Heubi, JE; Bishop, WP. Case Reports in Gastroenterology. 2018; 12:661-670.

Long-Term Cholic Acid Therapy in Zellweger Spectrum Disorders. Heubi, JE; Setchell, KD R; Bove, KE. Case Reports in Gastroenterology. 2018; 12:360-372.