A photo of Alan Jobe.

Alan H. Jobe, MD, PhD

  • Emeritus, UC Department of Pediatrics

About

Biography

My research areas include lung development, surfactant and bronchopulmonary dysplasia lung injury of the preterm ventilated lung. My goal is to develop a new treatment using lower dose antenatal steroids for women at risk of preterm delivery.

One of my groundbreaking discoveries is identifying the pharmacology of surfactant and its components in the preterm lung.

I have been a physician and researcher for more than 40 years. I began my work at Cincinnati Children’s in 1989, after 20 years at Harbor-UCLA Medical Center in Los Angeles.

Recognition and awards I’ve received include:

  • Virginia Apgar Award from the American Association of Pediatrics (AAP) 2011
  • Mary Ellen Award from the American Pediatric Society/Society for Pediatric Research (APS/SPR) 2017
  • E. Mead Johnson Award for Pediatric Research from SPR
  • Drake Medal from the University of Cincinnati School of Medicine
  • Founders Award from the Pediatric Assembly of the American Thoracic Association 2021

I served as chair of the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Neonatal Research Network Steering Committee from 1995 to 2005 and chair of the NICHD Global Research Network Steering Committee from 2009 to 2016. I was an associate editor for the Journal of Pediatrics for 18 years. I am a consultant for the Bill and Melinda Gates Foundation for infant mortality, and I was elected into the US National Institute of Medicine in 2007.

My research has been published in respected journals, such as the American Journal of Respiratory and Critical Care Medicine, American Journal of Physiology Lung Cellular and Molecular Physiology, The Journal of Pediatrics, and the American Journal of Obstetrics and Gynecology.

MD: University of California, San Diego, CA, 1973.

PhD: University of California, San Diego, CA, 1973.

Residency: University Hospital, University of California, San Diego, CA, 1974 to 1975.

Fellowship: University of California, San Diego, CA, 1975 to 1977.

Board Certified: Pediatrics and Neonatal-Perinatal Medicine.

Interests

Clinical trials in neonatology; bronchopulmonary dysplasia

Interests

Lung maturation and lung injury in the fetus and newborn; use of antenatal corticosteroids; lung injury with ventilation of the preterm

Research Areas

Neonatology, Perinatal Biology, Pulmonary Biology, Global Health

Publications

Chorioamnionitis induces changes in ovine pulmonary endogenous epithelial stem/progenitor cells in utero. Widowski, H; Ophelders, DR M G; van Leeuwen, AJ C N; Nikkels, PG J; Severens-Rijvers, CA H; LaPointe, VL S; Cleutjens, JP M; Hütten, MC; Kemp, MW; Payne, MS; et al. Pediatric Research. 2021; 90:549-558.

Budesonide with surfactant decreases systemic responses in mechanically ventilated preterm lambs exposed to fetal intra-amniotic lipopolysaccharide. Hillman, NH; Kemp, MW; Fee, E; Rittenschober-Böhm, J; Royse, E; Abugisisa, L; Salomone, F; Musk, GC; Jobe, AH. Pediatric Research. 2021; 90:328-334.

Blood myo-inositol concentrations in preterm and term infants. Brion, LP; Phelps, DL; Ward, RM; Nolen, TL; Hallman, NM K; Das, A; Zaccaro, DJ; Ball, MB; Watterberg, KL; Frantz, ID; et al. Journal of Perinatology. 2021; 41:247-254.

A striking result from antenatal exposure to N-acetylcysteine. Jobe, AH. Pediatric Research. 2021; 89:14-15.

Antenatal corticosteroids: a reappraisal of the drug formulation and dose. Jobe, AH; Kemp, M; Schmidt, A; Takahashi, T; Newnham, J; Milad, M. Pediatric Research. 2021; 89:318-325.

Variability in the efficacy of a standardized antenatal steroid treatment was independent of maternal or fetal plasma drug levels: evidence from a sheep model of pregnancy. Takahashi, T; Saito, M; Schmidt, AF; Usuda, H; Takahashi, Y; Watanabe, S; Hanita, T; Sato, S; Kumagai, Y; Koshinami, S; et al. American Journal of Obstetrics and Gynecology. 2020; 223:921.e1-921.e10.

Chorioamnionitis induces enteric nervous system injury: effects of timing and inflammation in the ovine fetus. Heymans, C; de Lange, IH; Lenaerts, K; Kessels, LC G A; Hadfoune, M; Rademakers, G; Melotte, V; Boesmans, W; Kramer, BW; Jobe, AH; et al. Molecular Medicine. 2020; 26.

Dose of budesonide with surfactant affects lung and systemic inflammation after normal and injurious ventilation in preterm lambs. Hillman, NH; Abugisisa, L; Royse, E; Fee, E; Kemp, MW; Kramer, BW; Schmidt, AF; Salomone, F; Clarke, MW; Musk, GC; et al. Pediatric Research. 2020; 88:726-732.

Other causes of fetal brain injury. Jobe, AH. American Journal of Obstetrics and Gynecology. 2020; 223.

Nanoparticle Delivery of Proangiogenic Transcription Factors into the Neonatal Circulation Inhibits Alveolar Simplification Caused by Hyperoxia. Bolte, C; Ustiyan, V; Ren, X; Dunn, AW; Pradhan, A; Wang, G; Kolesnichenko, OA; Deng, Z; Zhang, Y; Shi, D; et al. American Journal of Respiratory and Critical Care Medicine. 2020; 202:100-111.

From the Blog


Alan Jobe Honored with Drake Medal
Perinatal

Alan Jobe Honored with Drake Medal

Alan H. Jobe, MD, PhD7/16/2020

Jobe Receives 2016 Mary Ellen Avery Award
Perinatal

Jobe Receives 2016 Mary Ellen Avery Award

Alan H. Jobe, MD, PhD6/29/2019

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