A photo of Alan Jobe.

Director, Division of Perinatal Biology

Professor, UC Department of Pediatrics

513-636-8563

513-636-8691

Board Certified

My Biography & Research

Biography

My research areas include lung development, surfactant and bronchopulmonary dysplasia lung injury of the preterm ventilated lung. My goal is to develop a new treatment using antenatal steroids for women at risk of preterm delivery.

One of my groundbreaking discoveries is identifying the pharmacology of surfactant and its components in the preterm lung.

I have been a physician and researcher for more than 40 years. I began my work at Cincinnati Children’s in 1989.

Recognition and awards I’ve received include:

  • Virginia Apgar Award from the American Association of Pediatrics (AAP) 2011
  • Mary Ellen Award from the American Pediatric Society/Society for Pediatric Research (APS/SPR) 2017
  • E. Mead Johnson Award for Pediatric Research from SPR and the Drake Award from the University of Cincinnati School of Medicine 1999
  • Drake Medal from the University of Cincinnati School of Medicine

I served as chair of the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Neonatal Research Network Steering Committee from 1995 to 2005 and chair of the NICHD Global Research Network Steering Committee from 2009 to 2016. I was an associate editor for the Journal of Pediatrics for 18 years. I am a consultant for the Bill and Melinda Gates Foundation for infant mortality, and I was elected into the US National Institute of Medicine in 2007.

My research has been published in respected journals, such as the American Journal of Respiratory and Critical Care Medicine, American Journal of Physiology Lung Cellular and Molecular Physiology, The Journal of Pediatrics, and the American Journal of Obstetrics and Gynecology.

Clinical Interests

Clinical trials in neonatology; bronchopulmonary dysplasia

Research Interests

Lung maturation and lung injury in the fetus and newborn; use of antenatal corticosteroids; lung injury with ventilation of the preterm

Academic Affiliation

Professor, UC Department of Pediatrics

Clinical Divisions

Neonatology, Perinatal

Research Divisions

Neonatology, Perinatal Biology, Pulmonary Biology, Global Health



Blog Posts

Alan Jobe Honored with Drake Medal

Perinatal

Alan Jobe Honored with Drake Medal

Alan H. Jobe, MD, PhD7/16/2020

Jobe Receives 2016 Mary Ellen Avery Award

Perinatal

Jobe Receives 2016 Mary Ellen Avery Award

Alan H. Jobe, MD, PhD6/29/2019

My Education

MD: University of California, San Diego, CA, 1973.

PhD: University of California, San Diego, CA, 1973.

Residency: University Hospital, University of California, San Diego, CA, 1974 to 1975.

Fellowship: University of California, San Diego, CA, 1975 to 1977.

Board Certified: Pediatrics and Neonatal-Perinatal Medicine.

My Publications

Variability in the efficacy of a standardized antenatal steroid treatment was independent of maternal or fetal plasma drug levels: evidence from a sheep model of pregnancy. Takahashi, T; Saito, M; Schmidt, AF; Usuda, H; Takahashi, Y; Watanabe, S; Hanita, T; Sato, S; Kumagai, Y; Koshinami, S; et al. American Journal of Obstetrics and Gynecology. 2020; 223:921.e1-921.e10.

Chorioamnionitis induces enteric nervous system injury: Effects of timing and inflammation in the ovine fetus. Heymans, C; de Lange, IH; Lenaerts, K; Kessels, LC G A; Hadfoune, M; Rademakers, G; Melotte, V; Boesmans, W; Kramer, BW; Jobe, AH; et al. Molecular medicine (Cambridge, Mass.). 2020; 26.

Dose of budesonide with surfactant affects lung and systemic inflammation after normal and injurious ventilation in preterm lambs. Hillman, NH; Abugisisa, L; Royse, E; Fee, E; Kemp, MW; Kramer, BW; Schmidt, AF; Salomone, F; Clarke, MW; Musk, GC; et al. Pediatric Research. 2020; 88:726-732.

Other causes of fetal brain injury. Jobe, AH. American Journal of Obstetrics and Gynecology. 2020; 223:301-301.

Nanoparticle delivery of proangiogenic transcription factors into the neonatal circulation inhibits alveolar simplification caused by hyperoxia. Bolte, C; Ustiyan, V; Ren, X; Dunn, AW; Pradhan, A; Wang, G; Kolesnichenko, OA; Deng, Z; Zhang, Y; Shi, D; et al. American Journal of Respiratory and Critical Care Medicine. 2020; 202:100-111.

Lack of evidence for microbiota in the placental and fetal tissues of rhesus macaques. Theis, KR; Romero, R; Winters, AD; Jobe, AH; Gomez-Lopez, N. mSphere. 2020; 5.

Prophylactic intra-uterine β-cyclodextrin administration during intra-uterine ureaplasma parvum infection partly prevents liver inflammation without interfering with the enterohepatic circulation of the fetal sheep. Heymans, C; Heij, LR; Lenaerts, K; den Dulk, M; Hadfoune, M; van Heugten, C; Spiller, OB; Beeton, ML; Stock, SJ; Jobe, AH; et al. Nutrients. 2020; 12:1312-1312.

TNF-Signaling Modulates Neutrophil-Mediated Immunity at the Feto-Maternal Interface During LPS-Induced Intrauterine Inflammation. Presicce, P; Cappelletti, M; Senthamaraikannan, P; Ma, F; Morselli, M; Jackson, CM; Mukherjee, S; Miller, LA; Pellegrini, M; Jobe, AH; et al. Frontiers in Immunology. 2020; 11.

Chronic Intra-Uterine Ureaplasma parvum Infection Induces Injury of the Enteric Nervous System in Ovine Fetuses. Heymans, C; de Lange, IH; Hutten, MC; Lenaerts, K; de Ruijter, NJ E; Kessels, LC G A; Rademakers, G; Melotte, V; Boesmans, W; Saito, M; et al. Frontiers in Immunology. 2020; 11.

Pharmacokinetics and Pharmacodynamics of Intramuscular and Oral Betamethasone and Dexamethasone in Reproductive Age Women in India. Jobe, AH; Milad, MA; Peppard, T; Jusko, WJ. Clinical and Translational Science. 2020; 13:391-399.