A photo of Helen N. Jones.

Head of Research, Center for Fetal and Placental Research

Assistant Professor, UC Department of Surgery



Biography & Affiliation

Research Interests

Placental development and function; targeting the placenta for in utero treatments of pathological pregnancies; the placenta in congenital heart defects; the maternal-fetal interface in placental accreta spectrum

Academic Affiliation

Assistant Professor, UC Department of Surgery


General and Thoracic Surgery


BSc: University of St. Andrews, Scotland, 2000.

PhD: Rowett Research Institute, University of Aberdeen, Scotland, 2005.


Gab3 is required for IL-2-and IL-15-induced NK cell expansion and limits trophoblast invasion during pregnancy. Sliz, A; Locker, KC S; Lampe, K; Godarova, A; Plas, DR; Janssen, EM; Jones, H; Herr, AB; Hoebe, K. Science Immunology. 2019; 4:eaav3866-eaav3866.

Anthropoid primate-specific retroviral element THE1B controls expression of CRH in placenta and alters gestation length. Dunn-Fletcher, CE; Muglia, LM; Pavlicev, M; Wolf, G; Sun, M; Hu, Y; Huffman, E; Tumukuntala, S; Thiele, K; Mukherjee, A; et al. PLoS Biology. 2018; 16:e2006337-e2006337.

The Role of Abnormal Placentation in Congenital Heart Disease; Cause, Correlate, or Consequence?. Courtney, JA; Cnota, JF; Jones, HN. Frontiers in Physiology. 2018; 9.

Studies in genetically modified mice implicate maternal HDL as a mediator of fetal growth. Rebholz, SL; Melchior, JT; Davidson, WS; Jones, HN; Welge, JA; Prentice, AM; Moore, SE; Woollett, LA. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2018; 32:717-727.

Inverted formin 2 regulates intracellular trafficking, placentation, and pregnancy outcome. Lamm, KY B; Johnson, ML; Phillips, JB; Muntifering, MB; James, JM; Jones, HN; Redline, RW; Rokas, A; Muglia, LJ. eLife. 2018; 7.

Single-cell transcriptomics of the human placenta: inferring the cell communication network of the maternal-fetal interface. Pavlicev, M; Wagner, GP; Chavan, AR; Owens, K; Maziarz, J; Dunn-Fletcher, C; Kallapur, SG; Muglia, L; Jones, H. Genome Research. 2017; 27:349-361.

NF-kappa B decoy polyplexes decrease P-glycoprotein-mediated multidrug resistance in colorectal cancer cells. Abd Ellah, NH; Taylor, L; Ayres, N; Elmandy, MM; Fetih, GN; Jones, HN; Ibrahim, EA; Pauletti, GM. Cancer Gene Therapy. 2016; 23:149-155.

Hypoplastic left heart syndrome is associated with structural and vascular placental abnormalities and leptin dysregulation. Jones, HN; Olbrych, SK; Smith, KL; Cnota, JF; Habli, M; Ramos-Gonzales, O; Owens, KJ; Hinton, AC; Polzin, WJ; Muglia, LJ; et al. Placenta. 2015; 36:1078-1086.

CXCR3 blockade protects against Listeria monocytogenes infection-induced fetal wastage. Chaturvedi, V; Ertelt, JM; Jiang, TT; Kinder, JM; Xin, L; Owens, KJ; Jones, HN; Way, SS. Journal of Clinical Investigation. 2015; 125:1713-1725.

Development of Non-Viral, Trophoblast-Specific Gene Delivery for Placental Therapy. Abd Ellah, N; Taylor, L; Troja, W; Owens, K; Ayres, N; Pauletti, G; Jones, H. PLoS ONE. 2015; 10:e0140879-e0140879.