A photo of Helen N. Jones.

Head of Research, Center for Fetal and Placental Research

Assistant Professor, UC Department of Surgery



Biography & Affiliation

Research Interests

Placental development and function; targeting the placenta for in utero treatments of pathological pregnancies; the placenta in congenital heart defects; the maternal-fetal interface in placental accreta spectrum

Academic Affiliation

Assistant Professor, UC Department of Surgery


General and Thoracic Surgery


BSc: University of St. Andrews, Scotland, 2000.

PhD: Rowett Research Institute, University of Aberdeen, Scotland, 2005.


Courtney JA, Cnota JF, Jones HN. The Role of Abnormal Placentation in Congenital Heart Disease; Cause, Correlate, or Consequence? Frontiers in Physiology. 2018;9:1045.

Troja W, Owens K, Courtney J, Hinton A, Hinton R, Cnota J, Jones H. Abnormalities of placental development and function are associated with the different fetal growth patterns of hypoplastic left heart syndrome and transposition of the great arteries. bioRxiv. 2018.

Dunn-Fletcher CE, Muglia LM, Pavlicev M, Wolf G, Sun M-A, Hu Y-C, Huffman E, Tumukuntala S, Thiele K, Mukherjee A, Zoubovsky S, Zhang X, Swaggart KA, Lamm KYB, Jones HN, Macfarlan TS, Muglia LJ. Anthropoid primate-specific retroviral element THE1B controls expression of CRH in placenta and alters gestation length. PLoS Biology. 2018;16(9):e2006337.

Lamm KY, Johnson ML, Baker Phillips J, Muntifering M, James J, Jones HN, Redline RW, Rokas A, Muglia LJ. Inverted formin 2 regulates intracellular trafficking, placentation, and pregnancy outcome. eLife. 2018;7:e31150.

Pavlicev M, Wagner G, Chavan AR, Owens K, Maziarz J, Dunn-Fletcher C, Kallapur SG, Muglia L, Jones H. Single-cell transcriptomics of the human placenta; inferring the cell communication network of the maternal-fetal interface. Genome Research. 2017;27(3):349-361.

Rebholz SL, Melchior JT, Davidson WS, Jones HN, Welge JA, Prentice AM, Moore SE, Woollett LA. Studies in genetically modified mice implicate maternal HDL as a mediator of fetal growth. FASEB J. 2017.

Abd Ellah NH, Taylor L, Ayres N, Elmahdy MM, Fetih GN, Jones HN, Ibrahim EA, Pauletti GM. NF- κB decoy polyplexes decrease P-glycoprotein-mediated multidrug resistance in colorectal cancer cells. Cancer gene therapy. 2016;23(5):149-55.

Jones HN, Olbrych SK, Smith KS, Gonzales-Ramos O, Faust M, Habli M, Cnota CF, Hinton AC, Polzin WJ, Muglia LJ, Hinton RB. Hypoplastic left heart syndrome and related fetal growth abnormalities are associated with placental vascular micropathology and leptin dysregulation. Placenta. 2015;36(10):1078-1086.

Hassan N, Troja W, Klanke C, Pauletti G, Ayres N, Jones H. Non-viral Trophoblast-specific gene delivery in a model of Human Trophoblast. PLoSOne. 2015;10(10):e0140879.

Chaturvedi V, Ertelt JM, Jiang TT, Kinder JM, Xin L, Owens KJ, Jones HN, Way S. CXCR3 blockade protects against Listeria monocytogenes infection– induced fetal wastage. Journal of Clinical Investigation. 2015.