Sanjay K. Jain, MD

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Director, Division of Infectious Diseases
Albert B. Sabin Chair of Infectious Diseases
Professor, UC Department of Pediatrics

sanjay.jain@cchmc.org
(513) 636-7056
(513) 636-7655
Board Certified

About

Biography

We have gained recognition for pioneering molecular imaging technologies for infectious diseases, leading to novel ways of studying pathogenesis, diagnosis and monitoring of infections, and precision medicine approaches for patients with complicated infections. We have expertise in bacterial and fungal infections as well as and high-containment pathogens such as Mycobacterium tuberculosis (causative agent of tuberculosis). My laboratory utilizes small animal models and cutting-edge molecular imaging technologies (CT, PET, SPECT, MRI) to study disease pathogenesis as well as to develop precision medicine tools for patients. I am leading several first-in-human studies for novel imaging agents developed in my laboratory. I have several active NIH grants, and >140 peer-reviewed publications, many in high impact journals, co-authored with my trainees.

I am also involved with training the next generation of physicians, scientists and physician-scientists. From 2014 to 2022, I directed the Johns Hopkins ACGME-accredited Pediatric Infectious Diseases Fellowship Program. I was co-director (2018–2021) and then director and PI (2021–2025) of the NIH T32-AI052071 training grant that supported the Pediatric Infectious Diseases Fellowship program at Johns Hopkins.

I am funded through several NIH and other grants. Notably, I am also the recipient of the prestigious NIH Director’s New Innovator Award (2009) and the NIH Director’s Transformative Research Award (2014). I am the founding member and past chair, Infectious Diseases subgroup (2013–2021) and board of trustees of the World Molecular Imaging Society (2021–2025). I serve as a reviewer for multiple scientific journals and NIH study panels.

Interests

Pediatric infectious diseases; CNS infections; tuberculosis / mycobacterial infections; international health

Services and Specialties

Infectious Diseases

Publications

Beyond Rifampin: Evaluating Rifapentine and Rifabutin as Alternative Treatments for TB Meningitis. Chen, X; Ruiz-Gonzalez, CE; Masias-Leon, Y; Singh, M; Nino-Meza, OJ; Peloquin, CA; Artemov, D; Jain, SK. Journal of Infectious Diseases. 2026.

A clinical practice guideline for tuberculous meningitis. Donovan, J; Cresswell, FV; Tucker, EW; Davis, AG; Rohlwink, UK; Huynh, J; Solomons, R; Seddon, JA; Bahr, NC; Van Laarhoven, A; Rogozińska, E; Misra, UK; Figaji, A; Thwaites, GE. The Lancet Infectious Diseases. 2026; 26(2):e96-e111.

Intensified Treatment of Tuberculous Meningitis in Adults: A Systematic Review and Meta-analysis. Llamas-Lopez, A; Seddon, JA; Chow, FC; Upton, CM; Jain, SK; Alffenaar, J-W; Grint, DJ; Dooley, K; Aarnoutse, R; Cresswell, FV. Open Forum Infectious Diseases. 2025; 12(10):ofaf503.

Improved Radiosynthesis of [18F]-Labeled Oxazolidinone Antibiotics for Future Clinical Translation. Sarhan, M; Shelke, AM; Mane, K; Jadhav, R; Jeon, B; Nino-Meza, O; Chen, X; Freundlich, JS; Jain, SK; Carroll, L. ACS Infectious Diseases. 2025; 11(7):2009-2017.

18F-Fluorodeoxysorbitol PET for noninvasive detection of invasive mold infections: preclinical and first-in-human studies. Ruiz-Gonzalez, CE; Nino-Meza, OJ; Singh, M; Masias-Leon, Y; Kronenberg, A; Shambles, M; Chen, X; Tucker, EW; Lodge, MA; Carroll, LS; Cooke, KR; Kates, OS; Shoham, S; Zhang, SX; Jain, SK. Nature Communications. 2025; 16(1):6395.

Dynamic 11C-Para-Aminobenzoic Acid Positron Emission Tomography/Computed Tomography for Visualizing Pulmonary Mycobacteroides abscessus Infections. Masias-Leon, Y; Ruiz-Gonzalez, CE; Nino-Meza, OJ; Singh, M; Sarhan, MO; Chen, X; Flavahan, K; Kronenberg, A; Tucker, EW; Freundlich, JS; Lodge, MA; Carroll, LS; Parrish, N; Lechtzin, N; Jain, SK. American Journal of Respiratory and Critical Care Medicine. 2025; 211(7):1253-1263.

Proapoptotic Bcl-2 inhibitor as potential host directed therapy for pulmonary tuberculosis. Singh, M; Sarhan, MO; Damiba, NNL; Singh, AK; Villabona-Rueda, A; Nino-Meza, OJ; Chen, X; Masias-Leon, Y; Ruiz-Gonzalez, CE; Ordonez, AA; D'alessio, FR; Aboagye, EO; Carroll, LS; Jain, SK. Nature Communications. 2025; 16(1):3003.

Summary: Appropriate Use Criteria for the Use of Nuclear Medicine in Fever of Unknown Origin. Palestro, CJ; Abikhzer, G; Bar-Sever, Z; Bartel, T; Brady, R; Grady, EE; Israel, O; Jain, SK; Kandiah, S; Sathekge, MM; Shulkin, BL. Journal of Nuclear Medicine. 2024; 65(11):1786-1788.

Dynamic PET reveals compartmentalized brain and lung tissue antibiotic exposures of tuberculosis drugs. Chen, X; Arun, B; Nino-Meza, OJ; Sarhan, MO; Singh, M; Jeon, B; Mane, K; Shah, M; Tucker, EW; Carroll, LS; Freundlich, JS; Peloquin, CA; Ivaturi, VD; Jain, SK. Nature Communications. 2024; 15(1):6657.

Noninvasive Diagnostic Method to Objectively Measure Olfaction and Diagnose Smell Disorders by a Molecularly Targeted Fluorescence Imaging Agent. Adilbay, D; Gonzales, J; Zazhytska, M; Demetrio De Souza Franca, P; Roberts, S; Viray, TD; Artschwager, R; Patel, S; Kodra, A; Overdevest, JB; Carroll, LS; Lomvardas, S; Reiner, T; Pillarsetty, N. Journal of Nuclear Medicine. 2024; 65(8):1293-1300.

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