A photo of Xi Jason Jiang.

Professor, UC Department of Pediatrics



Biography & Affiliation


My research focuses on infectious diseases, with a primary study of viral pathogens that cause acute gastroenteritis, such as noroviruses and rotaviruses. My team and I also study influenza viruses based on our understanding of the host carbohydrate receptors' role in controlling host ranges and evolution that we learned from our research of noroviruses and rotaviruses.

Norovirus and rotavirus are both diverse pathogens that infect humans as well as animals. Their ability to cause infection is dependent on host carbohydrate receptors. Understanding the function of carbohydrate receptors in controlling norovirus evolution helps to elucidate their diversity, host ranges and species barriers. Our research will result in a better understanding of their epidemiology and provide evidence to support vaccine development against noroviruses and rotaviruses. Similar principles also apply to influenza viruses and coronaviruses.

We started our research on noroviruses and then extended to rotaviruses after finding similar principles of the role host carbohydrate receptors play in controlling host ranges and evolution of the two viral families. Our research is translational as host carbohydrates are important host susceptibility factors or convergent evolutional factors for many other viral and bacterial pathogens. Extending our study to influenza viruses was a logical choice.

Findings on the host carbohydrate receptors provide valuable information for vaccine development against the viral pathogens that cause gastroenteritis. Our extended discovery of the host sialic acid expression on zoonotic influenza viruses helps with our understanding of epidemiology for future vaccine development.

Our work is supported by the National Institutes of Health (NIH) and the Department of Defense (DOD). I have been a researcher for more than 37 years and began working with Cincinnati Children’s in 2001.

Research Interests

Infectious diseases; viral gastroenteritis

Academic Affiliation

Professor, UC Department of Pediatrics

Research Divisions

Infectious Diseases

Blog Posts

Nanoparticle Technology Licensed to Vaccine Development Firm

Infectious Diseases and Vaccines

Nanoparticle Technology Licensed to Vaccine Development Firm

Xi Jason Jiang, PhD, Ming Tan, PhD7/19/2021


BS: Public Health, Shanghai Medical University, Shanghai, China, 1978.

PhD: Baylor College of Medicine, Houston, TX, 1988.

Post-doctoral Fellow: Baylor College of Medicine, Houston, TX, 1993.


Structural basis of P[II] rotavirus evolution and host ranges under selection of histo-blood group antigens. Xu, S; McGinnis, KR; Liu, Y; Huang, P; Tan, M; Stuckert, MR; Burnside, RE; Jacob, EG; Ni, S; Jiang, X; et al. Proceedings of the National Academy of Sciences of the United States of America. 2021; 118.

Characterization of Functional Components in Bovine Colostrum That Inhibit Norovirus Capsid Protruding Domains Interacting with HBGA Ligands. Xue, Z; Han, Q; Huang, P; Jiang, X; Tan, M; Zhao, Y; Li, N; Zhang, R. Pathogens. 2021; 10.

Simvastatin Reduces Protection and Intestinal T Cell Responses Induced by a Norovirus P Particle Vaccine in Gnotobiotic Pigs. Kocher, J; Castellucci, TB; Wen, K; Li, G; Yang, X; Lei, S; Jiang, X; Yuan, L. Pathogens. 2021; 10.

Effects of rotavirus NSP4 protein on the immune response and protection of the SR69A-VP8* nanoparticle rotavirus vaccine. Liu, C; Huang, P; Zhao, D; Xia, M; Zhong, W; Jiang, X; Tan, M. Vaccine. 2021; 39:263-271.

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1. Klionsky, DJ; Abdel-Aziz, AK; Abdelfatah, S; Abdellatif, M; Abdoli, A; Abel, S; Abeliovich, H; Abildgaard, MH; Abudu, YP; Acevedo-Arozena, A; et al. Autophagy. 2021; 17:1-382.

Histo-blood group antigens as divergent factors of groups A and C rotaviruses circulating in humans and different animal species. Zhao, D; Liu, Y; Huang, P; Xia, M; Li, W; Tan, M; Zhang, X; Jiang, X. Emerging Microbes and Infections. 2020; 9:1609-1617.

Evaluation of the 50% Infectious Dose of Human Norovirus Cin-2 in Gnotobiotic Pigs: A Comparison of Classical and Contemporary Methods for Endpoint Estimation. Ramesh, AK; Parreño, V; Schmidt, PJ; Lei, S; Zhong, W; Jiang, X; Emelko, MB; Yuan, L. Viruses. 2020; 12.

Epidemiology and HBGA-susceptibility investigation of a G9P[8] rotavirus outbreak in a school in Lechang, China. Guo, L; Zhang, M; Hou, Y; Hu, H; Fang, L; Tan, M; Huang, Q; Li, H; Sun, L; Jiang, X; et al. Archives of Virology. 2020; 165:1311-1320.

Molecular basis of P[II] major human rotavirus VP8* domain recognition of histo-blood group antigens. Xu, S; Ahmed, LU; Stuckert, MR; McGinnis, KR; Liu, Y; Tan, M; Huang, P; Zhong, W; Zhao, D; Jiang, X; et al. PLoS Pathogens. 2020; 16.

Changes in norovirus genotype diversity in gastroenteritis outbreaks in Alberta, Canada: 2012-2018. Hasing, ME; Lee, BE; Qiu, Y; Xia, M; Pabbaraju, K; Wong, A; Tipples, G; Jiang, X; Pang, XL. BMC Infectious Diseases. 2019; 19.