A photo of Xi Jason Jiang.

Professor, UC Department of Pediatrics

513-636-0119

513-636-7655

Biography & Affiliation

Biography

My research focuses on infectious diseases, with a primary study of viral pathogens that cause acute gastroenteritis, such as noroviruses and rotaviruses. My team and I also study influenza viruses based on our understanding of the host carbohydrate receptors' role in controlling host ranges and evolution that we learned from our research of noroviruses and rotaviruses.

Norovirus and rotavirus are both diverse pathogens that infect humans as well as animals. Their ability to cause infection is dependent on host carbohydrate receptors. Understanding the function of carbohydrate receptors in controlling norovirus evolution helps to elucidate their diversity, host ranges and species barriers. Our research will result in a better understanding of their epidemiology and provide evidence to support vaccine development against noroviruses and rotaviruses. Similar principles also apply to influenza viruses and coronaviruses.

We started our research on noroviruses and then extended to rotaviruses after finding similar principles of the role host carbohydrate receptors play in controlling host ranges and evolution of the two viral families. Our research is translational as host carbohydrates are important host susceptibility factors or convergent evolutional factors for many other viral and bacterial pathogens. Extending our study to influenza viruses was a logical choice.

Findings on the host carbohydrate receptors provide valuable information for vaccine development against the viral pathogens that cause gastroenteritis. Our extended discovery of the host sialic acid expression on zoonotic influenza viruses helps with our understanding of epidemiology for future vaccine development.

Our work is supported by the National Institutes of Health (NIH) and the Department of Defense (DOD). I have been a researcher for more than 37 years and began working with Cincinnati Children’s in 2001.

Research Interests

Infectious diseases; viral gastroenteritis

Academic Affiliation

Professor, UC Department of Pediatrics

Divisions

Infectious Diseases

Education

BS: Public Health, Shanghai Medical University, Shanghai, China, 1978.

PhD: Baylor College of Medicine, Houston, TX, 1988.

Post-doctoral Fellow: Baylor College of Medicine, Houston, TX, 1993.

Publications

Epidemiology and HBGA-susceptibility investigation of a G9P[8] rotavirus outbreak in a school in Lechang, China. Guo, L; Zhang, M; Hou, Y; Hu, H; Fang, L; Tan, M; Huang, Q; Li, H; Sun, L; Jiang, X; et al. Archives of Virology. 2020; 165:1311-1320.

Molecular basis of P[II] major human rotavirus VP8* domain recognition of histo-blood group antigens. Xu, S; Ahmed, LU; Stuckert, MR; McGinnis, KR; Liu, Y; Tan, M; Huang, P; Zhong, W; Zhao, D; Jiang, X; et al. PLoS Pathogens. 2020; 16:e1008386-e1008386.

Changes in norovirus genotype diversity in gastroenteritis outbreaks in Alberta, Canada: 2012-2018. Hasing, ME; Lee, BE; Qiu, Y; Xia, M; Pabbaraju, K; Wong, A; Tipples, G; Jiang, X; Pang, XL. BMC Infectious Diseases. 2019; 19.

Parenterally administered P24-VP8* nanoparticle vaccine conferred strong protection against rotavirus diarrhea and virus shedding in gnotobiotic pigs. Ramesh, A; Mao, J; Lei, S; Twitchell, E; Shiraz, A; Jiang, X; Tan, M; Yuan, L. Vaccines. 2019; 7:177-177.

Enhanced GII.4 human norovirus infection in gnotobiotic pigs transplanted with a human gut microbiota. Lei, S; Twitchell, EL; Ramesh, AK; Bui, T; Majette, E; Tin, CM; Avery, R; Arango-Argoty, G; Zhang, L; Becker-Dreps, S; et al. The Journal of general virology. 2019; 100:1530-1540.

Protective immunity against influenza virus challenge by norovirus P particle-M2e and HA2-AtCYN vaccines in chickens. Elaish, M; Xia, M; Ngunjiri, JM; Ghorbani, A; Jang, H; KC, M; Abundo, MC; Dhakal, S; Gourapura, R; Jiang, X; et al. Vaccine. 2019; 37:6454-6462.

Norovirus capsid protein-derived nanoparticles and polymers as versatile platforms for antigen presentation and vaccine development. Tan, M; Jiang, X. Pharmaceutics. 2019; 11:472-472.

Immune response and protective efficacy of the S particle presented rotavirus VP8*vaccine in mice. Xia, M; Huang, P; Jiang, X; Tan, M. Vaccine. 2019; 37:4103-4110.

Heterosubtypic protection against avian influenza virus by live attenuated and chimeric norovirus P-particle-M2e vaccines in chickens. Ghorbani, A; Ngunjiri, JM; Xia, M; Elaish, M; Jang, H; Mahesh, KC; Abundo, MC; Jiang, X; Lee, CW. Vaccine. 2019; 37:1356-1364.

Structural Adaptations of Norovirus GII.17/13/21 Lineage through Two Distinct Evolutionary Paths. Qian, Y; Song, M; Jiang, X; Xia, M; Meller, J; Tan, M; Chen, Y; Li, X; Rao, Z. Journal of Virology. 2019; 93.