Mansa Krishnamurthy, MD, MSc
- Member, Division of Endocrinology
- Assistant Professor, UC Department of Pediatrics
- mansa.krishnamurthy@cchmc.org
- Board Certified
About
Biography
I'm an endocrinologist specializing in treating hormone disorders, including diabetes, thyroid disease, and growth and puberty problems. I provide compassionate, personalized care and enjoy developing connections with my patients and their families. My approach to care is family centered. I listen to the needs of my patients and their caregivers and work with them to devise a personalized treatment plan.
The research I conduct focuses on genetic forms of diabetes and congenital hyperinsulinism. We are interested in increasing our understanding of how genetic mutations cause anomalies in beta cell development leading to inadequate or excess insulin production and secretion. Our studies use translational and basic science approaches.
My research is supported by internal grants from Cincinnati Children’s and the American Diabetes Association. My work has been published in well-respected journals, including Gastroenterology, Nature Communications, Cell Stem Cell, Journal of Pathology, Endocrinology and Diabetologia.
When I'm not caring for patients or working in the lab, I enjoy spending time with my family, traveling and sampling foods from different parts of the world.
BSc: Anatomy and Cell Biology, McGill University, Montreal, QC, 2006.
MSc: Pathology, University of Western Ontario, ON, 2008.
MD: St. Georges University, Grenada, West Indies, 2013.
Pediatric Residency: East Carolina University, Greenville, NC, 2016.
Pediatric Endocrinology Fellowship: Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2020.
Research Fellowship: Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2021.
Interests
Pediatric endocrinology
Services and Specialties
Endocrinology
Interests
Disorders of beta cell function; monogenic diabetes; congenital hyperinsulinism
Insurance Information
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Publications
Using Human Induced Pluripotent Stem Cell-Derived Organoids to Identify New Pathologies in Patients With PDX1 Mutations. Gastroenterology. 2022; 163:1053-1063.e7.
Functional human gastrointestinal organoids can be engineered from three primary germ layers derived separately from pluripotent stem cells. Cell Stem Cell. 2022; 29:36-51.e6.
Adiponectin-induced ERK and Akt phosphorylation protects against pancreatic beta cell apoptosis and increases insulin gene expression and secretion. The Journal of biological chemistry. 2010; 285:33623-33631.
Transcription factor expression in the developing human fetal endocrine pancreas. Diabetologia. 2008; 51:1169-1180.
c-Kit in early onset of diabetes: a morphological and functional analysis of pancreatic beta-cells in c-KitW-v mutant mice. Endocrinology. 2007; 148:5520-5530.
Dual Role of Caspase 8 in Adipocyte Apoptosis and Metabolic Inflammation. Diabetes. 2023; 72:1751-1765.
221-OR: Retrospective Review of Genetic Mutations and Treatments in Patients with Monogenic Diabetes of the Youth (MODY). Diabetes. 2023; 72.
Nonsense mutation in the novel PERCC1 gene as a genetic cause of congenital diarrhea and enteropathy. Human Genetics. 2023; 142:691-696.
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