I provide compassionate, personalized care and enjoy developing connections with my patients and their families.
Mansa Krishnamurthy, MD, MSc

About

Biography

I'm an endocrinologist specializing in treating hormone disorders, including diabetes, thyroid disease, and growth and puberty problems. I provide compassionate, personalized care and enjoy developing connections with my patients and their families. My approach to care is family centered. I listen to the needs of my patients and their caregivers and work with them to devise a personalized treatment plan.

The research I conduct focuses on genetic forms of diabetes and congenital hyperinsulinism. We are interested in increasing our understanding of how genetic mutations cause anomalies in beta cell development leading to inadequate or excess insulin production and secretion. Our studies use translational and basic science approaches.

My research is supported by internal grants from Cincinnati Children’s and the American Diabetes Association. My work has been published in well-respected journals, including Gastroenterology, Nature Communications, Cell Stem Cell, Journal of Pathology, Endocrinology and Diabetologia.

When I'm not caring for patients or working in the lab, I enjoy spending time with my family, traveling and sampling foods from different parts of the world.

BSc: Anatomy and Cell Biology, McGill University, Montreal, QC, 2006.

MSc: Pathology, University of Western Ontario, ON, 2008.

MD: St. Georges University, Grenada, West Indies, 2013.

Pediatric Residency: East Carolina University, Greenville, NC, 2016.

Pediatric Endocrinology Fellowship: Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2020.

Research Fellowship: Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2021.

Interests

Pediatric endocrinology

Pediatric Endocrinology
Pediatric Endocrinology
Pediatric Endocrinology

Services and Specialties

Endocrinology

Interests

Disorders of beta cell function; monogenic diabetes; congenital hyperinsulinism

Insurance Information

Cincinnati Children's strives to accept a wide variety of health plans. Please contact your health insurance carrier to verify coverage for your specific benefit plan.

View Insurance Information

Publications

Selected

Using Human Induced Pluripotent Stem Cell-Derived Organoids to Identify New Pathologies in Patients With PDX1 Mutations. Krishnamurthy, M; Kechele, DO; Broda, T; Zhang, X; Enriquez, JR; McCauley, HA; Sanchez, JG; McCracken, K; Palermo, J; Bernieh, A; Neef, HC; Heider, A; Dauber, A; Wells, JM. Gastroenterology. 2022; 163:1053-1063.e7.

Selected

Functional human gastrointestinal organoids can be engineered from three primary germ layers derived separately from pluripotent stem cells. Eicher, AK; Kechele, DO; Sundaram, N; Berns, HM; Poling, HM; Haines, LE; Sanchez, JG; Kishimoto, K; Krishnamurthy, M; Han, L; Zorn, AM; Helmrath, MA; Wells, JM. Cell Stem Cell. 2022; 29:36-51.e6.

Selected

Adiponectin-induced ERK and Akt phosphorylation protects against pancreatic beta cell apoptosis and increases insulin gene expression and secretion. Wijesekara, N; Krishnamurthy, M; Bhattacharjee, A; Suhail, A; Sweeney, G; Wheeler, MB. The Journal of biological chemistry. 2010; 285:33623-33631.

Selected

Transcription factor expression in the developing human fetal endocrine pancreas. Lyttle, BM; Li, J; Krishnamurthy, M; Fellows, F; Wheeler, MB; Goodyer, CG; Wang, R. Diabetologia. 2008; 51:1169-1180.

Selected

c-Kit in early onset of diabetes: a morphological and functional analysis of pancreatic beta-cells in c-KitW-v mutant mice. Krishnamurthy, M; Ayazi, F; Li, J; Lyttle, AW; Woods, M; Wu, Y; Yee, S; Wang, R. Endocrinology. 2007; 148:5520-5530.

RFX6 regulates human intestinal patterning and function upstream of PDX1. Sanchez, JG; Rankin, S; Paul, E; McCauley, HA; Kechele, DO; Enriquez, JR; Jones, NH; Greeley, SA W; Letourneau-Friedberg, L; Zorn, AM; Krishnamurthy, M; Wells, JM. Development (Cambridge). 2024; 151.

Dual Role of Caspase 8 in Adipocyte Apoptosis and Metabolic Inflammation. Luk, CT; Chan, CK; Chiu, F; Shi, SY; Misra, PS; Li, YZ; Pollock-Tahiri, E; Schroer, SA; Desai, HR; Sivasubramaniyam, T; Yuen, DA; Hakem, A; Hakem, R; Woo, M. Diabetes. 2023; 72:1751-1765.

221-OR: Retrospective Review of Genetic Mutations and Treatments in Patients with Monogenic Diabetes of the Youth (MODY). DENG, L; SHAH, AS; KRISHNAMURTHY, M. Diabetes. 2023; 72.

Nonsense mutation in the novel PERCC1 gene as a genetic cause of congenital diarrhea and enteropathy. Marek-Yagel, D; Stenke, E; Pode-Shakked, B; Dunne, C; Crushell, E; Bryce-Smith, A; McDermott, M; O’Sullivan, MJ; Veber, A; Krishnamurthy, M; Wells, JM; Anikster, Y; Bourke, B. Human Genetics. 2023; 142:691-696.

Patient Ratings and Comments

All patient satisfaction ratings and comments are submitted by actual patients and verified by a leading independent patient satisfaction company, NRC Health. Patient identities are withheld to ensure confidentiality and privacy. Only those providers whose satisfaction surveys are administered through Cincinnati Children’s Hospital Medical Center are displayed. Click here to learn more about our survey

4.6
Overall Patient Rating