A photo of Rathnakumar Kumaragurubaran.

Rathnakumar Kumaragurubaran, PhD


  • Director, Single Cell Genomics Core
  • Assistant Professor, UC Department of Pediatrics

About

Biography

I received my PhD in Biotechnology in 2017 from the Indian Institute of Technology Madras. During my graduate years, I was trained in molecular biology and high-resolution microscopy. My postdoctoral fellowship focused on using multi-omics approaches to profile active gene regulatory elements in mouse models of liver and heart disease.

I spearheaded the NGS workflow development team in Dr. Michael Wilson’s laboratory (Genetics & Genomic Medicine Program, The Hospital for Sick Children), where I worked closely with internal stakeholders and external collaborators to implement a variety of NGS-based assays. I also designed insightful proof-of-concept (POC) experiments to determine technical feasibility, including predicting technical effort and risk.

In my current role, I help assess and prioritize single-cell and spatial assays, evaluating new and innovative genomics technologies and bioinformatics tools for potential service offerings.

As director, I support internal and federal user grant applications and expand the facility’s capabilities by delivering workshops and presentations to stakeholders to promote awareness of our services. I bring a well-rounded genomics skill set to the table, enabling me to design thoughtful experiments, guide bioinformatics analyses and interpretations, and propose future directions to peers and management.

Post Doc: University Health Network, Toronto General Hospital and The Hospital for Sick Children, Toronto, ON.

PhD: Indian Institute of Technology Madras, 2017.

Interests

To uncover gene and genome regulatory mechanisms that are relevant to developmental and disease processes.

Publications

Isolation and Culture of Human Umbilical Vein Endothelial Cells (HUVECs). Chandel, S; Kumaragurubaran, R; Giri, H; Dixit, M. Methods in molecular biology (Clifton, N.J.). 2024; 2711:147-162.