A photo of Michael Pauciulo.

Director, Discover Together Biobank

Assistant Professor, UC Department of Pediatrics

513-803-3842

Biography & Affiliation

Biography

As the director of the Discover Together Biobank at Cincinnati Children’s Hospital Medical Center, I work to provide an ongoing and growing institutional resource of biospecimens, clinical data and genomic data to help further research and increase grant competitiveness for all our researchers. Our end goal is to improve outcomes for our patients and our community.

My early career interest and research in pulmonary arterial hypertension (PAH) led me to working on the National Institutes of Health (NIH)-funded PAH Biobank. Built from scratch, the biobank is the largest consecutively enrolled collection of PAH patient participants in the world. The PAH Biobank is now a widely used resource that has resulted in numerous grants and publications.

My experience building the PAH Biobank led me to my position as director of the Discover Together Biobank. Discover Together actively partners with researchers at Cincinnati Children’s to provide biobanking infrastructure, institutional biospecimens and associated clinical/genetic data. Fostering internal and external collaboration whenever possible, Discover Together accelerates research and builds upon our existing resource for investigators at Cincinnati Children’s. My current research areas of interest include:

  • Biobanking
  • Biorepository projects
  • Community cohorts
  • Pulmonary arterial hypertension

Research Interests

Biobanking; biorepository projects; pulmonary arterial hypertension

Academic Affiliation

Assistant Professor, UC Department of Pediatrics

Research Divisions

Human Genetics

Education

MBA: University of Cincinnati, Cincinnati, OH, 2003.

Publications

United States Pulmonary Hypertension Scientific Registry: Baseline Characteristics. Badlam, JB; Badesch, DB; Austin, ED; Benza, RL; Chung, WK; Farber, HW; Feldkircher, K; Frost, AE; Poms, AD; Lutz, KA; et al. Chest. 2021; 159:311-327.

Bayesian Inference Associates Rare KDR Variants with Specific Phenotypes in Pulmonary Arterial Hypertension. Swietlik, EM; Greene, D; Zhu, N; Megy, K; Cogliano, M; Rajaram, S; Pandya, D; Tilly, T; Lutz, KA; Welch, CC L; et al. Circulation: Genomic and Precision Medicine. 2021.

Pediatric pulmonary hypertension: insulin-like growth factor-binding protein 2 is a novel marker associated with disease severity and survival. Griffiths, M; Yang, J; Nies, M; Vaidya, D; Brandal, S; Williams, M; Matsui, EC; Grant, T; Damico, R; Ivy, D; et al. Pediatric Research. 2020; 88:850-856.

Insulin-like growth factor binding protein-2: a new circulating indicator of pulmonary arterial hypertension severity and survival. Yang, J; Griffiths, M; Nies, MK; Brandal, S; Damico, R; Vaidya, D; Tao, X; Simpson, CE; Kolb, TM; Mathai, SC; et al. BMC Medicine. 2020; 18.

Phenotype-Agnostic Molecular Subtyping of Neurodegenerative Disorders: The Cincinnati Cohort Biomarker Program (CCBP). Sturchio, A; Marsili, L; Vizcarra, JA; Dwivedi, AK; Kauffman, MA; Duker, AP; Lu, P; Pauciulo, MW; Wissel, BD; Hill, EJ; et al. Frontiers in Aging Neuroscience. 2020; 12.

Elevated Interleukin-6 Levels Predict Clinical Worsening in Pediatric Pulmonary Arterial Hypertension. Chen, JY; Griffiths, M; Yang, J; Nies, MK; Damico, RL; Simpson, CE; Vaidya, RD; Brandal, S; Ivy, DD; Austin, ED; et al. Journal of Pediatrics. 2020; 223:164-169.e1.

Novel Mutations and Decreased Expression of the Epigenetic Regulator TET2 in Pulmonary Arterial Hypertension. Potus, F; Pauciulo, MW; Cook, EK; Zhu, N; Hsieh, A; Welch, CL; Shen, Y; Tian, L; Lima, P; Mewburn, J; et al. Circulation. 2020; 141:1986-2000.

Genetic Admixture and Survival in Diverse Populations with Pulmonary Arterial Hypertension. Karnes, JH; Wiener, H; Wiener, HW; Schwantes-An, T; Natarajan, B; Sweatt, AJ; Chaturvedi, A; Arora, AH; Arora, A; Batai, K; et al. American Journal of Respiratory and Critical Care Medicine. 2020; 201:1407-1415.

Noninvasive Prognostic Biomarkers for Left-Sided Heart Failure as Predictors of Survival in Pulmonary Arterial Hypertension. Simpson, CE; Damico, RL; Hassoun, PM; Martin, LJ; Yang, J; Nies, MK; Vaidya, RD; Brandal, S; Pauciulo, MW; Austin, ED; et al. Chest. 2020; 157:1606-1616.

Cellular sources of interleukin-6 and associations with clinical phenotypes and outcomes in pulmonary arterial hypertension. Simpson, CE; Chen, JY; Damico, RL; Hassoun, PM; Martin, LJ; Yang, J; Nies, M; Griffiths, M; Vaidya, RD; Brandal, S; et al. European Respiratory Journal, Supplement. 2020; 55.