Michael W. Pauciulo, MBA

Director, Discover Together Biobank
Assistant Professor, UC Department of Pediatrics

mike.pauciulo@cchmc.org

About

Biography

As the director of the Discover Together Biobank at Cincinnati Children’s Hospital Medical Center, I work to provide an ongoing and growing institutional resource of biospecimens, clinical data and genomic data to help further research and increase grant competitiveness for all our researchers. Our end goal is to improve outcomes for our patients and our community.

My early career interest and research in pulmonary arterial hypertension (PAH) led me to working on the National Institutes of Health (NIH)-funded PAH Biobank. Built from scratch, the biobank is the largest consecutively enrolled collection of PAH patient participants in the world. The PAH Biobank is now a widely used resource that has resulted in numerous grants and publications.

My experience building the PAH Biobank led me to my position as director of the Discover Together Biobank. Discover Together actively partners with researchers at Cincinnati Children’s to provide biobanking infrastructure, institutional biospecimens and associated clinical/genetic data. Fostering internal and external collaboration whenever possible, Discover Together accelerates research and builds upon our existing resource for investigators at Cincinnati Children’s. My current research areas of interest include:

Biobanking
Biorepository projects
Community cohorts
Pulmonary arterial hypertension

Interests

Biobanking; biorepository projects; pulmonary arterial hypertension

Research Areas

Human Genetics

Publications

Deriving Convergent and Divergent Metabolomic Correlates of Pulmonary Arterial Hypertension. Alotaibi, M; Liu, Y; Magalang, GA; Kwan, AC; Ebinger, JE; Nichols, WC; Pauciulo, MW; Jain, M; Cheng, S. Metabolites. 2023; 13:802.

SOX17 Deficiency Mediates Pulmonary Hypertension: At the Crossroads of Sex, Metabolism, and Genetics. Sangam, S; Sun, X; Schwantes-An, TH; Yegambaram, M; Lu, Q; Shi, Y; Cook, T; Fisher, A; Frump, AL; Coleman, A; et al. American Journal of Respiratory and Critical Care Medicine. 2023; 207:1055-1069.

Insulin-like growth factor binding Protein-4: A novel indicator of pulmonary arterial hypertension severity and survival. Torres, G; Yang, J; Griffiths, M; Brandal, S; Damico, R; Vaidya, D; Simpson, CE; Pauciulo, MW; Nichols, WC; Ivy, DD; et al. Pulmonary Circulation. 2023; 13:e12235.

RASA3 is a candidate gene in sickle cell disease-associated pulmonary hypertension and pulmonary arterial hypertension. Prohaska, CC; Zhang, X; Schwantes-An, TH L; Stearman, RS; Hooker, S; Kittles, RA; Aldred, MA; Lutz, KA; Pauciulo, MW; Nichols, WC; et al. Pulmonary Circulation. 2023; 13:e12227.

Genetic counselling and testing in pulmonary arterial hypertension: a consensus statement on behalf of the International Consortium for Genetic Studies in PAH. Eichstaedt, CA; Belge, C; Chung, WK; Gräf, S; Grünig, E; Montani, D; Quarck, R; Tenorio-Castano, JA; Soubrier, F; Trembath, RC; et al. The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology. 2023; 61:2201471.

Integrative Multiomics to Dissect the Lung Transcriptional Landscape of Pulmonary Arterial Hypertension. Hong, J; Wong, B; Rhodes, CJ; Kurt, Z; Schwantes-An, T; Mickler, EA; Gräf, S; Eyries, M; Lutz, KA; Pauciulo, MW; et al. 2023; 4:2023.01.12.523812.

Metabolomic Profiles Differentiate Scleroderma-PAH From Idiopathic PAH and Correspond With Worsened Functional Capacity. Alotaibi, M; Shao, J; Pauciulo, MW; Nichols, WC; Hemnes, AR; Malhotra, A; Kim, NH; Yuan, JX J; Fernandes, T; Kerr, KM; et al. Chest. 2023; 163:204-215.

Mining the Plasma Proteome for Insights into the Molecular Pathology of Pulmonary Arterial Hypertension. Harbaum, L; Rhodes, CJ; Wharton, J; Lawrie, A; Karnes, JH; Desai, AA; Nichols, WC; Humbert, M; Montani, D; Girerd, B; et al. American Journal of Respiratory and Critical Care Medicine. 2022; 205:1449-1460.

COL18A1 genotypic associations with endostatin levels and clinical features in pulmonary arterial hypertension: a quantitative trait association study. Simpson, CE; Griffiths, M; Yang, J; Nies, MK; Vaidya, D; Brandal, S; Martin, LJ; Pauciulo, MW; Lutz, KA; Coleman, AW; et al. ERJ Open Research. 2022; 8:725-2021.

Mendelian randomisation and experimental medicine approaches to interleukin-6 as a drug target in pulmonary arterial hypertension. Toshner, M; Church, C; Harbaum, L; Rhodes, C; Villar Moreschi, SS; Liley, J; Jones, R; Arora, A; Batai, K; Desai, AA; et al. The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology. 2022; 59:2002463.