A photo of S. Steven Potter.

S. Steven Potter, PhD

  • Professor, UC Department of Pediatrics

About

Biography

I was drawn to a career in research by a general curiosity about how the body develops. At Cincinnati Children’s Hospital Medical Center, I focus on understanding how the kidneys and lungs form.

My research career has spanned nearly five decades, during which I’ve led or been part of many notable discoveries. In the mid-70s, I worked on a team that discovered that mitochondrial DNA is maternally inherited. As a postdoctoral fellow, our research showed that repetitive DNA consists of transposable elements.

I was among the first to use transgene insertion to find novel development genes and my lab was among the first to carry to gene-targeted knockouts.

Research milestones I’ve participated in include:

  • First to clone, name and knockout a number of developmentally important genes
  • Among to the first to use microarrays, travel to Affymetrix
  • Among the first to carry out single-cell resolution gene expression experiments

BA: University of California, Los Angeles (UCLA), CA, 1971.

PhD: University of North Carolina, Chapel Hill, NC, 1976.

Postdoctoral Fellowship: Harvard Medical School, Boston, MA, 1976-1978.

Interests

Kidney development and disease; Hox genes; craniofacial development; creation of an atlas of global gene expression patterns in the multiple compartments of the developing kidney; analysis of perturbed gene expression patterns in the kidney glomeruli of patients with focal segmental glomerulosclerosis; craniofacial development using mutant mice, laser capture microdissection, next generation sequencing, and microarrays; recombineering to target multiple Hox genes at once

Research Areas

Developmental Biology, Fibrosis

Publications

Physical interactions between Gsx2 and Ascl1 balance progenitor expansion versus neurogenesis in the mouse lateral ganglionic eminence. Roychoudhury, K; Salomone, J; Qin, S; Cain, B; Adam, M; Pottert, SS; Nakafuku, M; Gebelein, B; Campbell, K. Development (Cambridge). 2020; 147.

Single cell RNA analysis identifies cellular heterogeneity and adaptive responses of the lung at birth. Guo, M; Du, Y; Gokey, JJ; Ray, S; Bell, SM; Adam, M; Sudha, P; Perl, AK; Deshmukh, H; Potter, SS; et al. Nature Communications. 2019; 10.

Single cell RNA-seq study of wild type and Hox9,10,11 mutant developing uterus. Mucenski, ML; Mahoney, R; Adam, M; Potter, AS; Potter, SS. Scientific Reports. 2019; 9.

Integrating gene regulatory pathways into differential network analysis of gene expression data. Grimes, T; Potter, SS; Datta, S. Scientific Reports. 2019; 9.

Pparg promotes differentiation and regulates mitochondrial gene expression in bladder epithelial cells. Liu, C; Tate, T; Batourina, E; Truschel, ST; Potter, S; Adam, M; Xiang, T; Picard, M; Reiley, M; Schneider, K; et al. Nature Communications. 2019; 10.

Identification of the Lymphangioleiomyomatosis Cell and Its Uterine Origin. Guo, M; Yu, JJ; Perl, AK; Wikenheiser-Brokamp, KA; Riccetti, M; Zhang, EY; Sudha, P; Adam, M; Potter, A; Kopras, EJ; et al. 2019.

Single-Cell Transcriptomics in Medulloblastoma Reveals Tumor-Initiating Progenitors and Oncogenic Cascades during Tumorigenesis and Relapse. Zhang, L; He, X; Liu, X; Zhang, F; Huang, LF; Potter, AS; Xu, L; Zhou, W; Zheng, T; Luo, Z; et al. Cancer Cell. 2019; 36:302-318.e7.

A bigenic mouse model of FSGS reveals perturbed pathways in podocytes, mesangial cells and endothelial cells. Potter, AS; Drake, K; Brunskill, EW; Potter, SS. PLoS ONE. 2019; 14.

Maturation of heart valve cell populations during postnatal remodeling. Hulin, A; Hortells, L; Gomez-Stallons, MV; O'Donnell, A; Chetal, K; Adam, M; Lancellotti, P; Oury, C; Potter, SS; Salomonis, N; et al. Development (Cambridge). 2019; 146.

Single-Cell Transcriptomics Uncovers Glial Progenitor Diversity and Cell Fate Determinants during Development and Gliomagenesis. Weng, Q; Wang, J; Wang, J; He, D; Cheng, Z; Zhang, F; Verma, R; Xu, L; Dong, X; Liao, Y; et al. Cell Stem Cell. 2019; 24:707-723.e8.