I was drawn to a career in research by a general curiosity about how the body develops. At Cincinnati Children’s Hospital Medical Center, I focus on understanding how the kidneys and lungs form.
My research career has spanned nearly five decades, during which I’ve led or been part of many notable discoveries. In the mid-70s, I worked on a team that discovered that mitochondrial DNA is maternally inherited. As a postdoctoral fellow, our research showed that repetitive DNA consists of transposable elements.
I was among the first to use transgene insertion to find novel development genes and my lab was among the first to carry to gene-targeted knockouts.
Research milestones I’ve participated in include:
- First to clone, name and knockout a number of developmentally important genes
- Among to the first to use microarrays, travel to Affymetrix
- Among the first to carry out single-cell resolution gene expression experiments
Kidney development and disease; Hox genes; craniofacial development; creation of an atlas of global gene expression patterns in the multiple compartments of the developing kidney; analysis of perturbed gene expression patterns in the kidney glomeruli of patients with focal segmental glomerulosclerosis; craniofacial development using mutant mice, laser capture microdissection, next generation sequencing, and microarrays; recombineering to target multiple Hox genes at once
Professor, UC Department of Pediatrics
Developmental Biology, Fibrosis