I was drawn to a career in research by a general curiosity about how the body develops. At Cincinnati Children’s Hospital Medical Center, I focus on understanding how the kidneys and lungs form.
My research career has spanned nearly five decades, during which I’ve led or been part of many notable discoveries. In the mid-70s, I worked on a team that discovered that mitochondrial DNA is maternally inherited. As a postdoctoral fellow, our research showed that repetitive DNA consists of transposable elements.
I was among the first to use transgene insertion to find novel development genes and my lab was among the first to carry to gene-targeted knockouts.
Research milestones I’ve participated in include:
- First to clone, name and knockout a number of developmentally important genes
- Among to the first to use microarrays, travel to Affymetrix
- Among the first to carry out single-cell resolution gene expression experiments