Member, Division of Experimental Hematology & Cancer Biology
Assistant Professor, UC Department of Pediatrics
Dr. Reynaud’s long-standing research interest is to understand the mechanisms controlling cell fate decisions in the hematopoietic system. During his graduate and post-graduate training, he worked to decipher the transcriptional regulatory networks that (i) control self-renewal activity and lineage specification in hematopoietic stem cells and (ii) regulate progenitor differentiation during the establishment of the natural and adaptive immune system. More recently he investigated the deregulation in stem and progenitor cell activity that, in adults, leads to the development of abnormal hematopoiesis and eventually to chronic myeloid leukemia. This work uncovered an unexpected contribution of the pro-inflammatory environment to leukemia development. Notably he identified a novel function for the pro-inflammatory cytokine IL-6 in reprogramming the fate of an early leukemic progenitor by promoting myeloid development at the expense of lymphoid differentiation. Following this work, the overall goal of his research at Cincinnati Children’s Hospital Medical Center is to characterize how micro-environmental signals regulate normal B lymphoid and how corruption of these signals contribute to the initiation, maintenance and progression of acute lymphoblastic leukemia.
Experimental Hematology and Cancer Biology
PhD: University Renee Descartes, Paris, France, 2004.
Postdoctoral Fellow: University of Chicago/HHMI, Chicago, IL, 2008; University of California, San Francisco, San Francisco, CA, 2013.
The signaling axis atypical protein kinase C lambda/iota-Satb2 mediates leukemic transformation of B-cell progenitors.
Nayak, RC; Hegde, S; Althoff, MJ; Wellendorf, AM; Mohmoud, F; Perentesis, J; Reina-Campos, M; Reynaud, D; Zheng, Y; Diaz-Meco, MT; et al.
Tuning of the Hematopoietic Stem Cell Compartment in its Inflammatory Environment.
Govindarajah, V; Reynaud, D.
Current Stem Cell Reports.
Obesity alters the long-term fitness of the hematopoietic stem cell compartment through modulation of Gfi1 expression.
Lee, J; Govindarajah, V; Goddard, B; Hinge, A; Muench, DE; Filippi, M; Aronow, B; Cancelas, JA; Salomonis, N; Grimes, HL; et al.
The Journal of Experimental Medicine.
Thermoneutral housing exacerbates nonalcoholic fatty liver disease in mice and allows for sex-independent disease modeling.
Giles, DA; Moreno-Fernandez, ME; Stankiewicz, TE; Graspeuntner, S; Cappelletti, M; Wu, D; Mukherjee, R; Chan, CC; Lawson, MJ; Klarquist, J; et al.
Functional evidence implicating chromosome 7q22 haploinsufficiency in myelodysplastic syndrome pathogenesis.
Wong, JC; Weinfurtner, KM; del pilar Alzamora, M; Kogan, SC; Burgess, MR; Zhang, Y; Nakitandwe, J; Ma, J; Cheng, J; Chen, SC; et al.
Functionally Distinct Subsets of Lineage-Biased Multipotent Progenitors Control Blood Production in Normal and Regenerative Conditions.
Pietras, EM; Reynaud, D; Kang, Y; Carlin, D; Calero-Nieto, FJ; Leavitt, AD; Stuart, JM; Goettgens, B; Passegue, E.
Cell Stem Cell.
Invasive breast cancer reprograms early myeloid differentiation in the bone marrow to generate immunosuppressive neutrophils.
Casbon, A; Reynaud, D; Park, C; Khuc, E; Gan, DD; Schepers, K; Passegue, E; Werb, Z.
Proceedings of the National Academy of Sciences of USA.
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