A photo of Brittany Simpson.

Assistant Professor, UC Department of Pediatrics


My Biography & Research

Clinical Interests

Behavioral phenotypes in common genetic syndromes; phenotypic variability; investigation and discovery of underlying mechanisms in undiagnosed cases; immunogenetics

Research Interests

Modifiers of disease severity; prognostic factors related to genetic syndromes; genetic risk factors in Dengue Fever; investigation of mechanisms involving TONSL dysfunction in SPONASTRIME dysplasia; characterization and outcomes in CHARGE syndrome; investigation of anxiety and parenting stress in 22q11.2 microdeletion syndrome

Academic Affiliation

Assistant Professor, UC Department of Pediatrics

Clinical Divisions

Human Genetics

Research Divisions

Human Genetics

My Locations

My Education

BA: University of Mississippi, Oxford, MS.

MD: University of Mississippi Medical Center, Jackson, MS.

Predoctoral Fellowship: National Institutes of Health, National Institute on Aging.

Residency: Pediatrics and Medical Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.

My Publications

Evaluation and classification of severity for 176 genes on an expanded carrier screening panel. Arjunan, A; Bellerose, H; Torres, R; Ben-Shachar, R; Hoffman, JD; Angle, B; Slotnick, RN; Simpson, BN; Lewis, AM; Magoulas, PL; et al. Prenatal Diagnosis. 2020; 40:1246-1257.

De Novo Pathogenic Variants in N-cadherin Cause a Syndromic Neurodevelopmental Disorder with Corpus Collosum, Axon, Cardiac, Ocular, and Genital Defects. Accogli, A; Calabretta, S; St-Onge, J; Boudrahem-Addour, N; Dionne-Laporte, A; Joset, P; Azzarello-Burri, S; Rauch, A; Krier, J; Fieg, E; et al. The American Journal of Human Genetics. 2019; 105:854-868.

Blood metabolite markers of cognitive performance and brain function in aging. Simpson, BN; Kim, M; Chuang, Y; Beason-Held, L; Kitner-Triolo, M; Kraut, M; Lirette, ST; Windham, BG; Griswold, ME; Legido-Quigley, C; et al. Journal of Cerebral Blood Flow and Metabolism. 2016; 36:1212-1223.

Blood metabolite markers of preclinical Alzheimer's disease in two longitudinally followed cohorts of older individuals. Casanova, R; Varma, S; Simpson, B; Kim, M; An, Y; Saldana, S; Riveros, C; Moscato, P; Griswold, M; Sonntag, D; et al. Alzheimer's and Dementia. 2016; 12:815-822.

Impaired cognition and brain atrophy decades after hypertensive pregnancy disorders. Mielke, MM; Milic, NM; Weissgerber, TL; White, WM; Kantarci, K; Mosley, TH; Windham, BG; Simpson, BN; Turner, ST; Garovic, VD. Circulation: Cardiovascular Quality and Outcomes. 2016; 9:S70-S76.