Photo of { Jeffrey D. Steimle, PhD}

Jeffrey D. Steimle, PhD

  • Member, Division of Molecular Cardiovascular Biology
  • Assistant Professor, UC Department of Pediatrics

About

Biography

As the Assistant Professor and Principal Investigator, I lead our team in defining and executing the lab’s scientific vision. My primary focus is on advancing our research goals while mentoring and training the next generation of scientists. I am a Chicagoland native who completed my BS at the University of Notre Dame, my PhD at the University of Chicago, and postdoctoral training at the Baylor College of Medicine. Outside of my career, I enjoy spending time with my growing family and our three dogs. In my limited free time, I am an avid PC gamer. 

BS: University of Notre Dame, Notre Dame, IN, 2011,

PhD: University of Chicago, Chicago, IL, 2019,

Postdoctoral Associated: Baylor College of Medicine, Houston, TX, 2025,

Research Areas

Publications

Selected

Gene therapy CM-YAPon protects the mouse heart from myocardial infarction. Meng, F; Steimle, JD; Straight, E; Li, RG; Morikawa, Y; Iqbal, Z; Xie, B; Wang, J; Paltzer, WG; Zhao, Y; Karch, JM; Pautler, RG; Li, X; Martin, JF. Nature Cardiovascular Research. 2025; 4(12):1616-1626.

Selected

Single-nuclei transcriptomics reveals TBX5-dependent targets in a patient with Holt-Oram syndrome. Steimle, JD; Zhao, Y; Meng, F; Taylor, ME; Turaga, D; Adachi, I; Li, X; Martin, JF. Journal of Clinical Investigation. 2024; 135(2).

Selected

ETV2 primes hematoendothelial gene enhancers prior to hematoendothelial fate commitment. Steimle, JD; Kim, C; Rowton, M; Nadadur, RD; Wang, Z; Stocker, M; Hoffmann, AD; Hanson, E; Kweon, J; Sinha, T; Choi, K; Black, BL; Cunningham, JM; Moskowitz, IP; Ikegami, K. Cell reports. 2023; 42(6):112665.

Selected

Decoding the PITX2-controlled genetic network in atrial fibrillation. Steimle, JD; Grisanti Canozo, FJ; Park, M; Kadow, ZA; Samee, MAH; Martin, JF. JCI Insight. 2022; 7(11).

Selected

Evolutionarily conserved Tbx5-Wnt2/2b pathway orchestrates cardiopulmonary development. Steimle, JD; Rankin, SA; Slagle, CE; Bekeny, J; Rydeen, AB; Chan, SS-K; Kweon, J; Yang, XH; Ikegami, K; Nadadur, RD; Jensen, B; Zorn, AM; Conlon, FL; Moskowitz, IP. Proceedings of the National Academy of Sciences of the United States of America. 2018; 115(45):E10615-E10624.

TEAD-independent mechanisms of YAP function in cardiomyocyte cell cycle reentry. Xie, B; Steimle, J; Deshmukh, V; Liu, L; Tsai, C-R; Heallen, TR; Paltzer, W; Morikawa, Y; Meng, F; Wang, J; Martin, JF. Life Science Alliance. 2026; 9(4).

YAP-Induced Glycolysis Drives Fibroinflammation and Disrupts Fibroblast Fidelity. Tsai, C-R; Liu, L; Zhao, Y; Kim, JH; Czarnewski, P; Li, RG; Meng, F; Zheng, M; Steimle, J; Zhao, X; Wang, J; Samee, MAH; Li, X; Martin, JF. Circulation Research. 2025; 137(12):1443-1458.

PITX2 dosage-dependent changes in pacemaker cell state underlie sinus node dysfunction and atrial arrhythmias. Van Der Maarel, LE; Mungroo, MR; Mulleners, OJ; Rivaud, MR; Verkerk, AO; Van Duijvenboden, K; Tiel Groenestege, FHT; Steimle, JD; Fokkert, L; De Gier-De Vries, C; Jensen, B; Boink, GJJ; Devalla, HD; Christoffels, VM. Nature Communications. 2025; 16(1):11197.

SARS-CoV-2 NSP13 interacts with TEAD to suppress Hippo-YAP signaling. Meng, F; Kim, JH; Tsai, C-R; Steimle, JD; Wang, J; Shi, Y; Li, RG; Xie, B; Deshmukh, V; Liu, S; Li, X; Martin, JF. eLife. 2025; 13.

SARS-CoV-2 NSP13 interacts with TEAD to suppress Hippo-YAP signaling. Meng, F; Kim, JH; Tsai, C-R; Steimle, JD; Wang, J; Shi, Y; Li, RG; Xie, B; Deshmukh, V; Liu, S; Li, X; Martin, JF. eLife. 2025; 13.

Give Today

3333 Burnet Avenue, Cincinnati, Ohio 45229-3026

© 1999-2025 Cincinnati Children's Hospital Medical Center. All rights reserved.

U.S. News & World Report Honor Roll Badge for Top Children's Hospital.Best Places to Work.America's Best Large Employers