A photo of Jeffery Steimle.

Jeffrey D. Steimle, PhD

  • Member, Division of Molecular Cardiovascular Biology
  • Assistant Professor, UC Department of Pediatrics

About

BS: University of Notre Dame, Notre Dame, IN, 2011.

PhD: University of Chicago, Chicago, IL, 2019.

Postdoctoral Associated: Baylor College of Medicine, Houston, TX, 2025.

Research Areas

Publications

Selected

Single-nuclei transcriptomics reveals TBX5-dependent targets in a patient with Holt-Oram syndrome. Steimle, JD; Zhao, Y; Meng, F; Taylor, ME; Turaga, D; Adachi, I; Li, X; Martin, JF. The Journal of Clinical Investigation. 2025; 135:e180670.

Selected

ETV2 primes hematoendothelial gene enhancers prior to hematoendothelial fate commitment. Steimle, JD; Kim, C; Rowton, M; Nadadur, RD; Wang, Z; Stocker, M; Hoffmann, AD; Hanson, E; Kweon, J; Sinha, T; Choi, K; Black, BL; Cunningham, JM; Moskowitz, IP; Ikegami, K. Cell Reports. 2023; 42:112665.

Selected

Decoding the PITX2-controlled genetic network in atrial fibrillation. Steimle, JD; Grisanti Canozo, FJ; Park, M; Kadow, ZA; Samee, MA H; Martin, JF. JCI insight. 2022; 7:e158895.

Selected

Transcriptional Patterning of the Ventricular Cardiac Conduction System. Burnicka-Turek, O; Broman, MT; Steimle, JD; Boukens, BJ; Petrenko, NB; Ikegami, K; Nadadur, RD; Qiao, Y; Arnolds, DE; Yang, XH; Patel, VV; Nobrega, MA; Efimov, IR; Moskowitz, IP. Circulation Research. 2020; 127:e94-e106.

Selected

Evolutionarily conserved Tbx5-Wnt2/2b pathway orchestrates cardiopulmonary development. Steimle, JD; Rankin, SA; Slagle, CE; Bekeny, J; Rydeen, AB; Chan, SS-K; Kweon, J; Yang, XH; Ikegami, K; Nadadur, RD; Jensen, B; Zorn, AM; Conlon, FL; Moskowitz, IP. Proceedings of the National Academy of Sciences of USA. 2018; 115:E10615-E10624.

Microtubules Sequester Acetylated YAP in the Cytoplasm and Inhibit Heart Regeneration. Liu, S; Deshmukh, V; Meng, F; Wang, Y; Morikawa, Y; Steimle, JD; Li, RG; Wang, J; Martin, JF. Circulation. 2025; 151:59-75.

A Genomic Link From Heart Failure to Atrial Fibrillation Risk: FOG2 Modulates a TBX5/GATA4-Dependent Atrial Gene Regulatory Network. Broman, MT; Nadadur, RD; Perez-Cervantes, C; Burnicka-Turek, O; Lazarevic, S; Gams, A; Laforest, B; Steimle, JD; Iddir, S; Wang, Z; Weber, CR; McNally, EM; Svensson, EC; Moskowitz, IP. Circulation. 2024; 149:1205-1230.

Endothelial cells adopt a pro-reparative immune responsive signature during cardiac injury. Long, H; Steimle, JD; Canozo, FJ G; Kim, JH; Li, X; Morikawa, Y; Park, M; Turaga, D; Adachi, I; Wythe, JD; Samee, MA H; Martin, JF. Life Science Alliance. 2024; 7:e202201870.

Sweet and sour story of maternal diabetes and birth defects. Steimle, JD; Martin, JF. Nature Cardiovascular Research. 2023; 2:1107-1108.

Abstract P2006: Cardiac Cytoskeleton Sequesters Acetylated Yap In The Cytoplasm To Inhibit Cardiomyocyte Renewal After Myocardial Infarction. Liu, S; Deshmukh, V; Meng, F; Wang, Y; Morikawa, Y; Steimle, J; Li, RG; Wang, J; Martin, JF. Circulation Research. 2023; 133.

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