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Director, Mass Spectrometry Lab
Professor, UC Department of Pediatrics
Kenneth D. Setchell, PhD, joined the tenured faculty of the Department of Pediatrics, University of Cincinnati College of Medicine in 1984, having moved from the Clinical Research Centre of the Medical Research Council, (UK) where he previously held a tenured scientific position. In 1973 he obtained a PhD in steroid biochemistry from the University of London. He was then awarded a fellowship from The Royal Society for post-doctoral studies at the Karolinska Institute in Stockholm, Sweden (1974-1975) in the application of mass spectrometry to clinical and biomedical problems specifically relating to the steroid hormone field. He returned to the United Kingdom to a scientific position in the Division of Clinical Chemistry at the Medical Research Council's Clinical Research Centre where he continued his research in the field of steroids, expanding into cholesterol and bile acid metabolism as it related to gastrointestinal diseases. His parallel research discoveries of the first mammalian lignans later led to the discovery of soy isoflavones in humans, their association with soy intake, and established his research in the area of bioactive plant constituents and human nutrition and disease.
In September 1984, Dr. Setchell moved to Cincinnati to become director of a new Clinical Mass Spectrometry facility at Cincinnati Children's Hospital Medical Center, and he is now a tenured professor in the Department of Pediatrics at the UC College of Medicine. His research program is internationally recognized as a leader in several areas of research that established collaborations with other groups from England, Italy, Germany, France Sweden, Canada and Australia. He has consulted with pharmaceutical and food companies, and to industries involved in clinical and biochemical research. Dr. Setchell cites >200 scientific publications and has presented over 250 papers at national and international symposia, while serving on national and international committees and editorial boards of international journals. Dr. Setchell was awarded the 1997 Gilbride award by the Canadian Liver Foundation for his contributions to the diagnosis and treatment of liver disease. He received awards from the AOCS at the 3rd International Symposium on the "Role of Soy in Preventing and Treating Chronic Disease" in 1999 for his outstanding contributions to increasing understanding and awareness of the health benefits of soy foods and soybean constituents, and from North American Menopause Society (NAMS) 2000 annual award for his research on soy and women's health. He received the Roche 2003 International Award for Innovative Research in Human Nutrition for his discoveries of classes of phytoestrogens and the 2004 Adolf Windaus Prize for research on bile acids and the discovery of genetic defects in the cholesterol-bile acid pathway causing liver disease.
Some of his most significant research contributions include the following:
Kenneth D. Setchell, PhD5/14/2020
Test-dose pharmacokinetics guided melphalan dose adjustment in reduced intensity conditioning allogeneic transplant for non-malignant disorders.
Chandra, S; Mizuno, K; Zhao, J; Davies, SM; Marsh, RA; Fukuda, T; Setchell, KD R; Vinks, AA; Mehta, PA.
British Journal of Clinical Pharmacology.
Paperspray Ionization Mass Spectrometry as a Tool for Predicting Real-Time Optimized Dosing of the Chemotherapeutic Drug Melphalan.
Zhao, J; Sharat, C; Mehta, PA; Mizuno, K; Vinks, AA; Setchell, KD R.
Journal of Applied Laboratory Medicine.
Regional comparison of self-reported late pregnancy cigarette smoking to mass spectrometry analysis.
Hall, ES; McAllister, JM; Kelly, EA; Setchell, KD R; Megaraj, V; Jimenez, KL; Nidey, N; Greenberg, JM; Wexelblatt, SL.
Journal of Perinatology.
Disorders of Bile Acid Synthesis and Metabolism in Children.
Setchell, KD R; Heubi, JE.
Liver Disease in Children.
Obeticholic acid ameliorates severity of Clostridioides difficile infection in high fat diet-induced obese mice.
Jose, S; Mukherjee, A; Horrigan, O; Setchell, KD R; Zhang, W; Moreno-Fernandez, ME; Andersen, H; Sharma, D; Haslam, DB; Divanovic, S; et al.
The impact of gastrointestinal dysmotility on the aerodigestive microbiome of pediatric lung transplant recipients.
Lötstedt, B; Boyer, D; Visner, G; Freiberger, D; Lurie, M; Kane, M; DiFilippo, C; Lundeberg, J; Narvaez-Rivas, M; Setchell, K; et al.
Journal of Heart Transplantation.
Modeling Human Bile Acid Transport and Synthesis in Stem Cell-Derived Hepatocytes with a Patient-Specific Mutation.
Hayashi, H; Osaka, S; Sakabe, K; Fukami, A; Kishimoto, E; Aihara, E; Sabu, Y; Mizutani, A; Kusuhara, H; Naritaka, N; et al.
Stem Cell Reports.
Assessment of the role of FGF15 in mediating the metabolic outcomes of murine Vertical Sleeve Gastrectomy (VSG).
Myronovych, A; Bhattacharjee, J; Salazar-Gonzalez, RM; Tan, B; Mowery, S; Ferguson, D; Ryan, KK; Zhang, W; Zhao, X; Oehrle, M; et al.
American Journal of Physiology - Gastrointestinal and Liver Physiology.
Abnormal Bilirubin Metabolism in Patients With Sodium Taurocholate Cotransporting Polypeptide Deficiency.
Yan, YY; Wang, MX; Gong, JY; Liu, LL; Setchell, KD R; Xie, XB; Wang, NL; Li, W; Wang, JS.
Journal of Pediatric Gastroenterology and Nutrition.
Model-Informed Bayesian Estimation Improves the Prediction of Morphine Exposure in Neonates and Infants.
Euteneuer, JC; Mizuno, T; Fukuda, T; Zhao, J; Setchell, KD R; Muglia, LJ; Vinks, AA.
Therapeutic Drug Monitoring.
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